OR10J1

Summary

OR10J1 (olfactory receptor family 10 subfamily J member 1, HGNC:8175) is a protein-coding gene on chromosome 1q23.2, encoding Olfactory receptor 10J1 (P30954). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26476 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_012351

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8175
Approved symbol	OR10J1
Name	olfactory receptor family 10 subfamily J member 1
Location	1q23.2
Locus type	gene with protein product
Status	Approved
Aliases	HGMP07J, HSHGMP07J
Ensembl gene	ENSG00000196184
Ensembl biotype	protein_coding
Entrez	26476

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000423932, ENST00000641630, ENST00000642080

RefSeq mRNA: 3 — MANE Select: NM_012351 NM_001363557, NM_001363558, NM_012351

CCDS: CCDS86023

Canonical transcript exons

ENST00000423932 — 1 exons

Exon	Start	End
ENSE00001772546	159439722	159440967

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 77.77.

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	77.77	silver quality
male germ cell	CL:0000015	75.49	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.89	gold quality
left testis	UBERON:0004533	69.79	gold quality
testis	UBERON:0000473	66.87	gold quality
cervix squamous epithelium	UBERON:0006922	66.74	gold quality
right testis	UBERON:0004534	65.50	gold quality
tibialis anterior	UBERON:0001385	62.39	silver quality
vena cava	UBERON:0004087	60.20	gold quality
secondary oocyte	CL:0000655	59.94	gold quality
deltoid	UBERON:0001476	58.78	gold quality
gluteal muscle	UBERON:0002000	58.37	gold quality
triceps brachii	UBERON:0001509	58.18	gold quality
quadriceps femoris	UBERON:0001377	56.58	gold quality
vastus lateralis	UBERON:0001379	55.62	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	54.86	gold quality
ileal mucosa	UBERON:0000331	54.21	silver quality
cervix epithelium	UBERON:0004801	53.89	gold quality
biceps brachii	UBERON:0001507	52.28	gold quality
oviduct epithelium	UBERON:0004804	51.14	gold quality
Brodmann (1909) area 46	UBERON:0006483	51.06	gold quality
epithelial cell of pancreas	CL:0000083	50.75	gold quality
orbitofrontal cortex	UBERON:0004167	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10J1 — P30954 (reviewed: P30954)

Alternative names: Olfactory receptor OR1-26, Olfactory receptor-like protein HGMP07J

All UniProt accessions (2): A0A126GWQ9, P30954

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (3): NP_001350486, NP_001350487, NP_036483* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 3, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P30954-F1	85.38	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 108–199

Glycosylation sites (2): 9, 16

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 47 (showing top): GOBP_SINGLE_FERTILIZATION, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, AP4_Q6, TAL1ALPHAE47_01, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOBP_FERTILIZATION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, HEB_Q6, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, TGATTTRY_GFI1_01, GOBP_SENSORY_PERCEPTION_OF_SMELL

GO Biological Process (6): G protein-coupled receptor signaling pathway (GO:0007186), single fertilization (GO:0007338), sensory perception of chemical stimulus (GO:0007606), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
fertilization	1
sensory perception	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

214 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10J1	ACTRT2	Q8TDY3	516
OR10J1	ZNF221	Q9UK13	507
OR10J1	KLHL25	Q9H0H3	476
OR10J1	FCER1A	P12319	471
OR10J1	ZSWIM1	Q9BR11	419
OR10J1	WDFY4	Q6ZS81	379
OR10J1	CADM3	Q8N126	368
OR10J1	DNHD1	Q96M86	366
OR10J1	GPATCH4	Q5T3I0	359
OR10J1	TC2N	Q8N9U0	321
OR10J1	BNIPL	Q7Z465	298
OR10J1	CEMP1	Q6PRD7	295
OR10J1	OLFML2B	Q68BL8	288
OR10J1	INSL6	Q9Y581	288
OR10J1	CACNG1	Q06432	284

IntAct

2 interactions, top by confidence:

A	B	Type	Score
TRAF6	OR10J1	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A6NCV1, A6NL08, O76000, O95007, O95221, P0C626, P0C629, P0DMU2, P30954, P30955, P37070, P37071, P58181, P70526, Q15617, Q60882, Q60890, Q60893, Q60895, Q6IEU7, Q8N0Y5, Q8NGG4, Q8NGG6, Q8NGG7, Q8NGH3, Q8NGI7, Q8NGP6, Q8NGP8, Q8NGP9, Q8NGT1, Q8NGX3, Q8NH01, Q8NH04, Q8NH74, Q8NH79, Q8NHC4, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

214 predictions. Top by Δscore:

Variant	Effect	Δscore
1:159440460:A:AG	acceptor_gain	0.9600
1:159440458:A:AG	acceptor_gain	0.7800
1:159440042:GCCTC:G	donor_gain	0.7300
1:159440459:C:G	acceptor_gain	0.7300
1:159440461:A:G	acceptor_gain	0.6700
1:159440047:G:GG	donor_gain	0.6600
1:159440546:GCT:G	acceptor_gain	0.6600
1:159440050:G:A	donor_gain	0.5900
1:159440467:A:AG	acceptor_gain	0.5700
1:159440046:C:CG	donor_gain	0.5600
1:159440046:CGTAG:C	donor_loss	0.5600
1:159440047:GTAG:G	donor_loss	0.5600
1:159440048:TAGGT:T	donor_loss	0.5600
1:159440049:AGGT:A	donor_loss	0.5600
1:159440050:GGTAT:G	donor_loss	0.5600
1:159440051:GTAT:G	donor_loss	0.5600
1:159440052:T:G	donor_loss	0.5600
1:159440442:T:G	acceptor_gain	0.5600
1:159440462:T:G	acceptor_gain	0.5200
1:159440468:A:G	acceptor_gain	0.5200
1:159440466:CAAGA:C	acceptor_gain	0.5100
1:159440053:A:C	donor_loss	0.4700
1:159440467:AAGA:A	acceptor_gain	0.4700
1:159440652:G:GA	donor_gain	0.4700
1:159439967:T:G	donor_gain	0.4600
1:159440465:TCAAG:T	acceptor_gain	0.4600
1:159439754:C:G	donor_gain	0.4400
1:159440490:G:GT	donor_gain	0.4400
1:159439744:GAC:G	donor_gain	0.4300
1:159440464:CTCAA:C	acceptor_gain	0.4300

AlphaMissense

2023 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:159440293:T:C	F179L	0.935
1:159440295:C:A	F179L	0.935
1:159440295:C:G	F179L	0.935
1:159440281:T:C	F175L	0.925
1:159440283:C:A	F175L	0.925
1:159440283:C:G	F175L	0.925
1:159440317:T:C	F187L	0.916
1:159440319:C:A	F187L	0.916
1:159440319:C:G	F187L	0.916
1:159439840:T:C	F28L	0.915
1:159439842:C:A	F28L	0.915
1:159439842:C:G	F28L	0.915
1:159440545:A:C	S263R	0.910
1:159440547:C:A	S263R	0.910
1:159440547:C:G	S263R	0.910
1:159440320:T:C	F188L	0.901
1:159440322:C:A	F188L	0.901
1:159440322:C:G	F188L	0.901
1:159440500:T:C	F248L	0.888
1:159440502:T:A	F248L	0.888
1:159440502:T:G	F248L	0.888
1:159439825:T:C	F23L	0.883
1:159439827:T:A	F23L	0.883
1:159439827:T:G	F23L	0.883
1:159440395:A:C	S213R	0.866
1:159440397:T:A	S213R	0.866
1:159440397:T:G	S213R	0.866
1:159439882:T:C	F42L	0.859
1:159439884:C:A	F42L	0.859
1:159439884:C:G	F42L	0.859

dbSNP variants (sampled 300 via entrez): RS1000011035 (1:159437602 G>C,T), RS1000011958 (1:159417861 T>C), RS1000041590 (1:159417629 C>A), RS1000110691 (1:159413143 C>T), RS1000312225 (1:159410061 G>A), RS1000316693 (1:159400389 A>G), RS1000353390 (1:159409871 C>T), RS1000355494 (1:159438793 G>A,T), RS1000448384 (1:159395856 G>T), RS1000457654 (1:159410408 C>A), RS1000534309 (1:159439377 A>G), RS1000538486 (1:159414097 C>T), RS1000567687 (1:159433517 A>G), RS1000606692 (1:159413282 G>A,C), RS1000674260 (1:159401367 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000080_18	Hemostatic factors and hematological phenotypes	2.000000e-07
GCST000083_14	Select biomarker traits	4.000000e-12
GCST000628_7	Chemerin levels	8.000000e-06
GCST001650_1	C-reactive protein	1.000000e-37
GCST001650_11	C-reactive protein	3.000000e-10
GCST001650_8	C-reactive protein	4.000000e-73
GCST001762_115	Obesity-related traits	6.000000e-06
GCST001762_307	Obesity-related traits	1.000000e-21

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement
EFO:0004573	chemerin measurement
EFO:0004458	C-reactive protein measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
testosterone undecanoate	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
Amphotericin B	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression	1
Aflatoxin B1	decreases methylation	1
Levonorgestrel	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.