OR10J3

Summary

OR10J3 (olfactory receptor family 10 subfamily J member 3 (gene/pseudogene), HGNC:14992) is a protein-coding gene on chromosome 1q23.2, encoding Olfactory receptor 10J3 (Q5JRS4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This gene is considered a pseudogene because the encoded protein is truncated and missing the last transmembrane domain in several mammals.

Source: NCBI Gene 441911 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 49 total
• Druggable target: yes

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14992
Approved symbol	OR10J3
Name	olfactory receptor family 10 subfamily J member 3 (gene/pseudogene)
Location	1q23.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196266
Ensembl biotype	protein_coding
Entrez	441911

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000649616

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000649616 — 1 exons

Exon	Start	End
ENSE00003836138	159313720	159314659

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 44.22.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	44.22	gold quality
colonic epithelium	UBERON:0000397	41.86	gold quality
granulocyte	CL:0000094	40.99	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
sural nerve	UBERON:0015488	36.12	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
liver	UBERON:0002107	32.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right lobe of liver	UBERON:0001114	30.47	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.74	gold quality
urinary bladder	UBERON:0001255	29.01	gold quality
leukocyte	CL:0000738	28.90	gold quality
monocyte	CL:0000576	28.25	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	26.93	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
uterine cervix	UBERON:0000002	24.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10j3	ENSMUSG00000046643
mus_musculus	Or10j3b	ENSMUSG00000049456
rattus_norvegicus	Or10j3	ENSRNOG00000072322
rattus_norvegicus	Or10j3b	ENSRNOG00000078843

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10J3 — Q5JRS4 (reviewed: Q5JRS4)

All UniProt accessions (1): A0A3B3IUB4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5JRS4-F1	75.06	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, chr1q23

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

187 predictions. Top by Δscore:

Variant	Effect	Δscore
1:159313974:ATCT:A	acceptor_gain	0.7700
1:159313975:TCTT:T	acceptor_gain	0.7700
1:159314119:C:CT	acceptor_gain	0.7100
1:159314149:C:CT	acceptor_gain	0.7100
1:159313973:AATCT:A	acceptor_gain	0.6900
1:159313976:CTTA:C	acceptor_gain	0.6900
1:159313977:T:A	acceptor_gain	0.6900
1:159314068:T:C	donor_gain	0.6800
1:159313915:CCA:C	acceptor_gain	0.6700
1:159313916:CAC:C	acceptor_gain	0.6700
1:159313983:A:AC	acceptor_gain	0.6700
1:159313977:T:TC	acceptor_gain	0.6500
1:159314121:C:CT	acceptor_gain	0.6400
1:159314114:C:CT	acceptor_gain	0.6300
1:159313977:T:C	acceptor_gain	0.6200
1:159313986:G:GC	acceptor_gain	0.6200
1:159314003:A:C	acceptor_gain	0.6200
1:159314151:C:CT	acceptor_gain	0.5900
1:159313772:T:TA	donor_gain	0.5800
1:159313916:CA:C	acceptor_gain	0.5700
1:159313983:A:C	acceptor_gain	0.5600
1:159314024:C:CT	acceptor_gain	0.5600
1:159313995:A:C	acceptor_gain	0.5400
1:159314025:A:C	acceptor_gain	0.5300
1:159313862:CTGGG:C	donor_gain	0.5200
1:159313915:C:CT	donor_gain	0.5200
1:159314003:A:AC	acceptor_gain	0.5200
1:159314023:CCA:C	acceptor_gain	0.5200
1:159314024:C:T	acceptor_gain	0.5100
1:159313976:C:CC	acceptor_gain	0.5000

AlphaMissense

2042 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:159314165:A:C	F165L	0.884
1:159314165:A:T	F165L	0.884
1:159314167:A:G	F165L	0.884
1:159314624:G:C	F12L	0.878
1:159314624:G:T	F12L	0.878
1:159314626:A:G	F12L	0.878
1:159314609:G:C	F17L	0.873
1:159314609:G:T	F17L	0.873
1:159314611:A:G	F17L	0.873
1:159314153:G:C	F169L	0.872
1:159314153:G:T	F169L	0.872
1:159314155:A:G	F169L	0.872
1:159314123:G:C	F179L	0.851
1:159314123:G:T	F179L	0.851
1:159314125:A:G	F179L	0.851
1:159314048:G:C	S204R	0.838
1:159314048:G:T	S204R	0.838
1:159314050:T:G	S204R	0.838
1:159313943:A:C	F239L	0.817
1:159313943:A:T	F239L	0.817
1:159313945:A:G	F239L	0.817
1:159314564:G:C	F32L	0.813
1:159314564:G:T	F32L	0.813
1:159314566:A:G	F32L	0.813
1:159314126:G:C	F178L	0.807
1:159314126:G:T	F178L	0.807
1:159314128:A:G	F178L	0.807
1:159314351:G:C	F103L	0.784
1:159314351:G:T	F103L	0.784
1:159314353:A:G	F103L	0.784

dbSNP variants (sampled 300 via entrez): RS1000209561 (1:159313098 T>C), RS1001328296 (1:159315402 C>T), RS1001383763 (1:159315704 C>G,T), RS1001602438 (1:159315905 T>C), RS1004617112 (1:159314973 A>T), RS1004690583 (1:159314670 C>A), RS1005476324 (1:159314953 AATT>A), RS1005803317 (1:159316405 C>CT), RS1005854481 (1:159316563 C>T), RS1007210398 (1:159316627 C>T), RS1007286013 (1:159315085 G>T), RS1009817382 (1:159314153 G>A), RS1010039560 (1:159315951 G>A), RS1011024676 (1:159315886 G>A), RS1012960731 (1:159314040 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000083_16	Select biomarker traits	1.000000e-14
GCST000628_4	Chemerin levels	7.000000e-06
GCST001316_8	IgE levels	2.000000e-16
GCST001650_1	C-reactive protein	1.000000e-37
GCST001650_11	C-reactive protein	3.000000e-10
GCST001650_8	C-reactive protein	4.000000e-73
GCST002875_125	Diisocyanate-induced asthma	2.000000e-06
GCST004610_33	White blood cell count	4.000000e-13

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004573	chemerin measurement
EFO:0004458	C-reactive protein measurement
EFO:0006995	response to diisocyanate

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067080 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.76	Kd	1725	nM	CHEMBL5653589
5.76	ED50	1725	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148915: Binding affinity to human OR10J3 incubated for 45 mins by Kinobead based pull down assay	kd	1.7253	uM

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression	1
CGP 52608	increases reaction, affects binding	1
Resveratrol	decreases expression, affects cotreatment	1
Glyphosate	increases expression	1
Benzo(a)pyrene	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651957	Binding	Binding affinity to human OR10J3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.