OR10J5

Summary

OR10J5 (olfactory receptor family 10 subfamily J member 5, HGNC:14993) is a protein-coding gene on chromosome 1q23.2, encoding Olfactory receptor 10J5 (Q8NHC4). Olfactory receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127385 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001004469

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14993
Approved symbol	OR10J5
Name	olfactory receptor family 10 subfamily J member 5
Location	1q23.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184155
Ensembl biotype	protein_coding
OMIM	619546
Entrez	127385

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000334857

RefSeq mRNA: 1 — MANE Select: NM_001004469 NM_001004469

CCDS: CCDS30910

Canonical transcript exons

ENST00000334857 — 1 exons

Exon	Start	End
ENSE00001336708	159535078	159536007

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 81.32.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.32	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.32	gold quality
liver	UBERON:0002107	43.77	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	35.89	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
muscle tissue	UBERON:0002385	32.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.68	gold quality
leukocyte	CL:0000738	29.49	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.97	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.05	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
cortex of kidney	UBERON:0001225	25.71	gold quality
muscle of leg	UBERON:0001383	24.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): LHX2

Literature-anchored findings (GeneRIF, showing 1)

• data demonstrate the physiological role of OR10J5 in angiogenesis and represent roles of ORs in HUVEC cells (PMID:25791473)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10j5	ENSMUSG00000037924
rattus_norvegicus	Or10j5	ENSRNOG00000091073

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10J5 — Q8NHC4 (reviewed: Q8NHC4)

Alternative names: Olfactory receptor OR1-28

All UniProt accessions (2): A0A126GV70, Q8NHC4

UniProt curated annotations — full annotation on UniProt →

Function. Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway. Also acts as a regulator of angiogenesis. Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway. May be involved in sperm chemotaxis and motility.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in both the aorta, the coronary artery and umbilical vein endothelial cells (HUVECs) (at protein level).

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004469* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NHC4-F1	86.04	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–188

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 45 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_LIPID_HOMEOSTASIS, GOBP_TAXIS, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT, GOBP_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION, GOBP_BLOOD_VESSEL_MORPHOGENESIS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT, GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOBP_MUSCLE_CELL_DIFFERENTIATION, GOBP_HOMEOSTATIC_PROCESS, GOBP_CHEMICAL_HOMEOSTASIS

GO Biological Process (11): angiogenesis (GO:0001525), chemotaxis (GO:0006935), G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187), muscle organ development (GO:0007517), sensory perception of smell (GO:0007608), regulation of angiogenesis (GO:0045765), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), regulation of muscle cell differentiation (GO:0051147), lipid homeostasis (GO:0055088), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor signaling pathway	2
transmembrane signaling receptor activity	2
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
response to chemical	1
taxis	1
animal organ development	1
muscle structure development	1
sensory perception of chemical stimulus	1
angiogenesis	1
regulation of anatomical structure morphogenesis	1
regulation of vasculature development	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
muscle cell differentiation	1
regulation of cell differentiation	1
chemical homeostasis	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10J5	ADCY3	O60266	509
OR10J5	GPSM1	Q86YR5	495
OR10J5	CNGA2	Q16280	461
OR10J5	OPRM1	P35372	452
OR10J5	GNG7	O60262	451
OR10J5	GNAL	P38405	413
OR10J5	A0A140T9Z0	A0A140T9Z0	410
OR10J5	UGT2A1	P0DTE4	363
OR10J5	OR2L8	Q8NGY9	362
OR10J5	TYR	P14679	343
OR10J5	FCER1A	P12319	328
OR10J5	ZNRF2	Q8NHG8	324
OR10J5	ANKRD44	Q8N8A2	314
OR10J5	OR6K2	Q8NGY2	307
OR10J5	PRB3	Q04118	298

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR10J5	PCDHB3	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): PCDHB3 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, Q60881, Q62007, Q6IF82, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGE8, Q8NGF8, Q8NGF9, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGN8, Q8NGS8, Q8NGT0, Q8NH21, Q8NH42, Q8NH43, Q8NH49, Q8NH70, Q8NH72, Q8NH83, Q8NH85

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

215 predictions. Top by Δscore:

Variant	Effect	Δscore
1:159535935:T:C	donor_gain	0.8500
1:159535337:A:C	acceptor_gain	0.7900
1:159535488:C:CT	donor_gain	0.7900
1:159535489:T:TT	donor_gain	0.7900
1:159535589:AGTC:A	donor_gain	0.7800
1:159535945:T:A	donor_gain	0.7700
1:159535832:A:C	donor_gain	0.7600
1:159535985:T:TA	donor_gain	0.7600
1:159535981:CA:C	donor_gain	0.7400
1:159535337:A:AC	acceptor_gain	0.7200
1:159535330:T:C	acceptor_gain	0.7000
1:159535491:CCA:C	donor_gain	0.7000
1:159535326:CAATT:C	acceptor_gain	0.6900
1:159535492:CAC:C	donor_gain	0.6900
1:159535981:CACTT:C	donor_gain	0.6800
1:159535315:CTCAG:C	acceptor_gain	0.6600
1:159535327:A:T	acceptor_gain	0.6600
1:159535868:G:C	donor_gain	0.6600
1:159535317:CAG:C	acceptor_gain	0.6500
1:159535491:C:CT	donor_gain	0.6500
1:159535316:TCA:T	acceptor_gain	0.6400
1:159535330:T:TC	acceptor_gain	0.6200
1:159535320:C:CC	acceptor_gain	0.6100
1:159535357:A:C	acceptor_gain	0.6100
1:159535318:AG:A	acceptor_gain	0.5800
1:159535346:A:C	acceptor_gain	0.5800
1:159535979:G:T	donor_gain	0.5800
1:159535316:TCAG:T	acceptor_gain	0.5700
1:159535317:CAGC:C	acceptor_gain	0.5700
1:159535346:A:AC	acceptor_gain	0.5700

AlphaMissense

2028 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:159535957:A:C	F17L	0.873
1:159535957:A:T	F17L	0.873
1:159535959:A:G	F17L	0.873
1:159535972:G:C	F12L	0.873
1:159535972:G:T	F12L	0.873
1:159535974:A:G	F12L	0.873
1:159535504:G:C	F168L	0.844
1:159535504:G:T	F168L	0.844
1:159535506:A:G	F168L	0.844
1:159535480:G:C	F176L	0.835
1:159535480:G:T	F176L	0.835
1:159535482:A:G	F176L	0.835
1:159535516:G:C	F164L	0.820
1:159535516:G:T	F164L	0.820
1:159535518:A:G	F164L	0.820
1:159535915:G:C	F31L	0.817
1:159535915:G:T	F31L	0.817
1:159535917:A:G	F31L	0.817
1:159535297:A:C	F237L	0.765
1:159535297:A:T	F237L	0.765
1:159535299:A:G	F237L	0.765
1:159535702:G:C	F102L	0.751
1:159535702:G:T	F102L	0.751
1:159535704:A:G	F102L	0.751
1:159535138:A:C	S290R	0.741
1:159535138:A:T	S290R	0.741
1:159535140:T:G	S290R	0.741
1:159535477:A:C	F177L	0.740
1:159535477:A:T	F177L	0.740
1:159535479:A:G	F177L	0.740

dbSNP variants (sampled 300 via entrez): RS1001513521 (1:159538004 G>GA), RS1003358605 (1:159536903 T>G), RS1006187624 (1:159537850 T>G), RS1007863129 (1:159537454 T>C), RS1008101638 (1:159534886 T>C), RS1008979068 (1:159536996 C>T), RS1010627656 (1:159536607 T>G), RS1011076003 (1:159536882 T>A,C,G), RS1012288718 (1:159535007 G>A,T), RS1014423793 (1:159537934 A>G), RS1015706645 (1:159537355 C>T), RS1015784278 (1:159535743 T>A,G), RS1015879459 (1:159535466 T>C), RS1018239552 (1:159537474 C>A,G,T), RS1018255492 (1:159535779 T>A,G)

Disease associations

OMIM: gene MIM:619546 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST000080_18	Hemostatic factors and hematological phenotypes	2.000000e-07
GCST001650_1	C-reactive protein	1.000000e-37
GCST001650_11	C-reactive protein	3.000000e-10
GCST001650_8	C-reactive protein	4.000000e-73
GCST001762_115	Obesity-related traits	6.000000e-06
GCST001762_307	Obesity-related traits	1.000000e-21

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement
EFO:0004458	C-reactive protein measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
bisphenol S	decreases expression, affects cotreatment	1
Benzo(a)pyrene	increases methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.