OR10K1

Summary

OR10K1 (olfactory receptor family 10 subfamily K member 1, HGNC:14693) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 10K1 (Q8NGX5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391109 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001004473

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14693
Approved symbol	OR10K1
Name	olfactory receptor family 10 subfamily K member 1
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000173285
Ensembl biotype	protein_coding
Entrez	391109

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000641235, ENST00000641432, ENST00000641460, ENST00000641535, ENST00000641971

RefSeq mRNA: 1 — MANE Select: NM_001004473 NM_001004473

CCDS: CCDS30897

Canonical transcript exons

ENST00000641535 — 2 exons

Exon	Start	End
ENSE00003813689	158465406	158467458
ENSE00003813792	158461834	158461904

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 75.53.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.45	gold quality
colonic epithelium	UBERON:0000397	46.30	gold quality
bone marrow cell	CL:0002092	43.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	41.70	gold quality
calcaneal tendon	UBERON:0003701	39.89	gold quality
ventricular zone	UBERON:0003053	39.83	gold quality
granulocyte	CL:0000094	37.28	gold quality
sural nerve	UBERON:0015488	36.72	gold quality
skeletal muscle tissue	UBERON:0001134	36.60	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	35.48	gold quality
tonsil	UBERON:0002372	35.30	gold quality
muscle tissue	UBERON:0002385	33.42	gold quality
leukocyte	CL:0000738	31.23	gold quality
liver	UBERON:0002107	31.10	gold quality
monocyte	CL:0000576	30.95	gold quality
urinary bladder	UBERON:0001255	30.82	gold quality
prefrontal cortex	UBERON:0000451	30.10	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
adrenal tissue	UBERON:0018303	29.72	gold quality
blood	UBERON:0000178	29.22	gold quality
lymph node	UBERON:0000029	28.67	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.46	gold quality
cortex of kidney	UBERON:0001225	27.19	gold quality
uterine cervix	UBERON:0000002	27.09	gold quality
gastrocnemius	UBERON:0001388	26.90	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.40
E-GEOD-137537	no	3.56

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10k2	ENSMUSG00000047286
rattus_norvegicus	Or10k2	ENSRNOG00000073756

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 10K1 — Q8NGX5 (reviewed: Q8NGX5)

Alternative names: Olfactory receptor OR1-6

All UniProt accessions (2): Q8NGX5, A0A126GV64

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004473* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX5-F1	88.04	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 5, 265

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GLI1_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

140 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10K1	ACSM6	Q6P461	480
OR10K1	MSLNL	Q96KJ4	473
OR10K1	CNBD1	Q8NA66	431
OR10K1	NCR1	O76036	389
OR10K1	MFAP4	P55083	387
OR10K1	FBP1	P09467	366
OR10K1	TPRA1	Q86W33	363
OR10K1	UGT3A2	Q3SY77	352
OR10K1	LANCL1	O43813	336
OR10K1	CEACAM16	Q2WEN9	325
OR10K1	EBLN2	Q6P2I7	321
OR10K1	BHLHE23	Q8NDY6	317
OR10K1	FRYL	O94915	313
OR10K1	MAGEA6	P43360	312
OR10K1	ARF1	P10947	311

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10K1 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

340 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158466206:A:AG	acceptor_gain	0.7700
1:158466207:G:GG	acceptor_gain	0.7700
1:158465627:GC:G	donor_gain	0.6600
1:158465738:G:GG	donor_gain	0.6500
1:158466300:GTG:G	donor_gain	0.6500
1:158466222:A:AG	acceptor_gain	0.6400
1:158466240:A:G	acceptor_gain	0.6400
1:158466257:T:A	acceptor_gain	0.6300
1:158466299:TGTG:T	donor_loss	0.5900
1:158466302:GGTAA:G	donor_loss	0.5900
1:158466303:GTA:G	donor_loss	0.5900
1:158466304:T:A	donor_loss	0.5900
1:158466303:G:GG	donor_gain	0.5600
1:158466432:A:AG	acceptor_gain	0.5600
1:158466433:G:GG	acceptor_gain	0.5600
1:158465637:C:G	donor_gain	0.5500
1:158466239:A:AG	acceptor_gain	0.5500
1:158465583:GTG:G	donor_gain	0.5400
1:158465976:GGG:G	donor_gain	0.5400
1:158465977:GG:G	donor_gain	0.5400
1:158465977:GGG:G	donor_gain	0.5400
1:158465978:GG:G	donor_gain	0.5400
1:158466302:G:GA	donor_gain	0.5400
1:158466121:T:A	acceptor_gain	0.5300
1:158466256:TTGGA:T	acceptor_gain	0.5300
1:158465799:A:AC	acceptor_gain	0.5200
1:158466155:C:A	donor_gain	0.5200
1:158466259:G:GT	donor_gain	0.5200
1:158466260:A:C	acceptor_gain	0.5200
1:158466075:A:AG	acceptor_gain	0.5100

AlphaMissense

2029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158465595:T:C	F12L	0.931
1:158465597:C:A	F12L	0.931
1:158465597:C:G	F12L	0.931
1:158465610:T:C	F17L	0.921
1:158465612:C:A	F17L	0.921
1:158465612:C:G	F17L	0.921
1:158466051:T:C	F164L	0.910
1:158466053:T:A	F164L	0.910
1:158466053:T:G	F164L	0.910
1:158466063:T:C	F168L	0.888
1:158466065:C:A	F168L	0.888
1:158466065:C:G	F168L	0.888
1:158465871:T:C	F104L	0.883
1:158465873:C:A	F104L	0.883
1:158465873:C:G	F104L	0.883
1:158466093:T:C	F178L	0.879
1:158466095:C:A	F178L	0.879
1:158466095:C:G	F178L	0.879
1:158466090:T:C	F177L	0.878
1:158466092:C:A	F177L	0.878
1:158466092:C:G	F177L	0.878
1:158466432:A:C	S291R	0.875
1:158466434:T:A	S291R	0.875
1:158466434:T:G	S291R	0.875
1:158465926:G:C	R122P	0.861
1:158466318:A:C	S253R	0.839
1:158466320:T:A	S253R	0.839
1:158466320:T:G	S253R	0.839
1:158465643:T:C	F28L	0.830
1:158465645:T:A	F28L	0.830

dbSNP variants (sampled 300 via entrez): RS1000548236 (1:158467935 C>T), RS1000675181 (1:158462929 A>G), RS1000869562 (1:158460890 T>C), RS1001026226 (1:158460702 G>A), RS1001361388 (1:158461913 C>T), RS1001362085 (1:158461636 G>A), RS1001403885 (1:158460219 G>A), RS1001435799 (1:158467287 C>G), RS1002309 (1:158463284 A>C,G,T), RS1002357770 (1:158461540 C>T), RS1002408279 (1:158461392 T>C), RS1002599 (1:158465460 C>T), RS1002953139 (1:158464189 C>A), RS1003048748 (1:158463125 A>T), RS1003367861 (1:158463970 GA>G,GAA)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, increases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation	2
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.