OR10K2

Summary

OR10K2 (olfactory receptor family 10 subfamily K member 2, HGNC:14826) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 10K2 (Q6IF99). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391107 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_001004476

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14826
Approved symbol	OR10K2
Name	olfactory receptor family 10 subfamily K member 2
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000180708
Ensembl biotype	protein_coding
Entrez	391107

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641042

RefSeq mRNA: 1 — MANE Select: NM_001004476 NM_001004476

CCDS: CCDS30896

Canonical transcript exons

ENST00000641042 — 2 exons

Exon	Start	End
ENSE00003812123	158418210	158420927
ENSE00003814151	158425933	158426237

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 44.98.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	44.98	gold quality
colonic epithelium	UBERON:0000397	41.35	gold quality
mucosa of transverse colon	UBERON:0004991	37.14	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.39	gold quality
skeletal muscle tissue	UBERON:0001134	34.84	gold quality
muscle tissue	UBERON:0002385	33.24	gold quality
duodenum	UBERON:0002114	32.43	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
lymph node	UBERON:0000029	31.01	gold quality
liver	UBERON:0002107	30.43	gold quality
monocyte	CL:0000576	30.18	gold quality
leukocyte	CL:0000738	29.94	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.34	gold quality
blood	UBERON:0000178	28.65	gold quality
right uterine tube	UBERON:0001302	28.62	gold quality
cortex of kidney	UBERON:0001225	28.46	gold quality
muscle of leg	UBERON:0001383	27.84	gold quality
urinary bladder	UBERON:0001255	27.54	gold quality
smooth muscle tissue	UBERON:0001135	27.45	gold quality
primary visual cortex	UBERON:0002436	27.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.33	gold quality
tonsil	UBERON:0002372	27.05	gold quality
gastrocnemius	UBERON:0001388	26.78	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10K2 — Q6IF99 (reviewed: Q6IF99)

Alternative names: Olfactory receptor OR1-4

All UniProt accessions (2): Q6IF99, A0A126GV65

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004476* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IF99-F1	87.30	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 5, 265

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, BOCHKIS_FOXA2_TARGETS, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

112 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10K2	MSLNL	Q96KJ4	512
OR10K2	ACSM6	Q6P461	509
OR10K2	NKAPL	Q5M9Q1	434
OR10K2	CEACAM16	Q2WEN9	376
OR10K2	BHLHE23	Q8NDY6	348
OR10K2	CNGB3	Q9NQW8	301
OR10K2	KIF22	Q14807	291
OR10K2	DEFA4	P12838	278
OR10K2	HTR5A	P47898	270
OR10K2	VIL1	P09327	256
OR10K2	TAS2R60	P59551	253
OR10K2	HOXD11	P31277	248
OR10K2	NANOS2	P60321	248
OR10K2	RAD23A	P54725	248
OR10K2	IL36A	Q9UHA7	245
OR10K2	KCTD19	Q17RG1	245

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: O43749, O76000, O95221, P0C629, P0C7N5, P0DMU2, P23269, P23272, P23274, P30955, P59922, P70526, Q15617, Q15620, Q60882, Q60890, Q60893, Q60895, Q6IEU7, Q6IF36, Q6IF99, Q6UXT6, Q8NGF4, Q8NGG6, Q8NGG7, Q8NGG8, Q8NGI7, Q8NGL2, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGX5, Q8NGZ4, Q8NH04, Q8NH10, Q8NH69, Q8NH79, Q8VF76, Q8VFK2

Diamond homologs: A6NND4, B2ZHY2, B4XF06, E7EM37, O02664, O08858, O43194, O88319, P0C0L6, P20789, P20905, P21917, P30989, P32250, P35404, P35406, P41595, P42291, P51582, Q4G072, Q5U431, Q61H86, Q6IF99, Q6RYS9, Q6XXX8, Q8BMC0, Q8BZP8, Q8HZ64, Q8UUG8, Q923Y1, Q923Y4, O00254, O15974, P07700, P79250, Q28422, Q56H79, Q58D85, Q93126, Q96R48

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

191 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158420799:AG:A	donor_gain	0.7000
1:158420579:G:GA	donor_gain	0.6800
1:158420658:TCAGA:T	acceptor_gain	0.6800
1:158420800:G:GA	donor_gain	0.6500
1:158420580:C:A	donor_gain	0.6300
1:158420520:G:GA	donor_gain	0.6200
1:158420842:CCA:C	donor_gain	0.6200
1:158420252:CAATG:C	acceptor_gain	0.6000
1:158420509:AAC:A	donor_gain	0.5900
1:158420578:AG:A	donor_gain	0.5800
1:158420831:G:T	donor_gain	0.5800
1:158420040:A:AC	donor_gain	0.5700
1:158420041:C:CC	donor_gain	0.5700
1:158420352:T:TC	acceptor_gain	0.5700
1:158420510:A:C	donor_gain	0.5700
1:158420618:A:AT	donor_gain	0.5700
1:158420168:AC:A	donor_gain	0.5500
1:158420169:CC:C	donor_gain	0.5500
1:158420578:AGC:A	donor_gain	0.5500
1:158420791:G:C	donor_gain	0.5500
1:158420842:C:CT	donor_gain	0.5500
1:158420253:A:T	acceptor_gain	0.5400
1:158420691:A:C	donor_gain	0.5400
1:158420508:TA:T	donor_gain	0.5300
1:158420509:AA:A	donor_gain	0.5300
1:158420599:T:TA	donor_gain	0.5300
1:158420686:A:C	donor_gain	0.5300
1:158420829:A:AC	donor_gain	0.5300
1:158420168:A:AC	donor_gain	0.5200
1:158420169:C:CC	donor_gain	0.5200

AlphaMissense

2032 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158420816:G:C	F17L	0.917
1:158420816:G:T	F17L	0.917
1:158420818:A:G	F17L	0.917
1:158420375:A:C	F164L	0.905
1:158420375:A:T	F164L	0.905
1:158420377:A:G	F164L	0.905
1:158420555:G:C	F104L	0.893
1:158420555:G:T	F104L	0.893
1:158420557:A:G	F104L	0.893
1:158420333:G:C	F178L	0.889
1:158420333:G:T	F178L	0.889
1:158420335:A:G	F178L	0.889
1:158420336:G:C	F177L	0.887
1:158420336:G:T	F177L	0.887
1:158420338:A:G	F177L	0.887
1:158419994:G:C	S291R	0.845
1:158419994:G:T	S291R	0.845
1:158419996:T:G	S291R	0.845
1:158420363:A:C	F168L	0.828
1:158420363:A:T	F168L	0.828
1:158420365:A:G	F168L	0.828
1:158420502:C:G	R122P	0.823
1:158420783:A:C	F28L	0.815
1:158420783:A:T	F28L	0.815
1:158420785:A:G	F28L	0.815
1:158420513:C:A	M118I	0.807
1:158420513:C:G	M118I	0.807
1:158420513:C:T	M118I	0.807
1:158420561:A:C	F102L	0.807
1:158420561:A:T	F102L	0.807

dbSNP variants (sampled 300 via entrez): RS1000541524 (1:158423876 G>A), RS1000597958 (1:158417788 G>A), RS1001035473 (1:158423551 A>G), RS1001195029 (1:158419702 C>T), RS1001217417 (1:158423531 A>G), RS1001315954 (1:158424946 C>A,T), RS1001431319 (1:158427306 G>C,T), RS1001693743 (1:158419305 G>A), RS1002487966 (1:158422036 T>C), RS1003096850 (1:158426189 G>A,T), RS1003329786 (1:158427140 T>C), RS1003360924 (1:158427343 A>C), RS1005006296 (1:158428232 A>G), RS1005178091 (1:158424737 C>G), RS1005567990 (1:158427677 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Estradiol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.