OR10P1

Summary

OR10P1 (olfactory receptor family 10 subfamily P member 1, HGNC:15378) is a protein-coding gene on chromosome 12q13.2, encoding Olfactory receptor 10P1 (Q8NGE3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 121130 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 69 total
• MANE Select transcript: NM_206899

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15378
Approved symbol	OR10P1
Name	olfactory receptor family 10 subfamily P member 1
Location	12q13.2
Locus type	gene with protein product
Status	Approved
Aliases	OST701
Ensembl gene	ENSG00000175398
Ensembl biotype	protein_coding
Entrez	121130

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000309675

RefSeq mRNA: 1 — MANE Select: NM_206899 NM_206899

CCDS: CCDS31828

Canonical transcript exons

ENST00000309675 — 1 exons

Exon	Start	End
ENSE00001183692	55636892	55637833

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 56.45.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	56.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.93	gold quality
bone marrow cell	CL:0002092	38.24	gold quality
granulocyte	CL:0000094	37.34	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
heart	UBERON:0000948	35.98	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.06	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
blood	UBERON:0000178	32.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.32	gold quality
duodenum	UBERON:0002114	28.14	gold quality
leukocyte	CL:0000738	27.94	gold quality
heart left ventricle	UBERON:0002084	27.72	silver quality
lymph node	UBERON:0000029	27.57	gold quality
monocyte	CL:0000576	27.34	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.96	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.21	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10p1	ENSMUSG00000052012
rattus_norvegicus	Or10p1	ENSRNOG00000079528

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10P1 — Q8NGE3 (reviewed: Q8NGE3)

Alternative names: Olfactory receptor 10P2, Olfactory receptor 10P3, Olfactory receptor OR12-7

All UniProt accessions (1): Q8NGE3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_996782* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGE3-F1	88.30	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

144 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10P1	PRR32	B1ATL7	505
OR10P1	NLRP8	Q86W28	460
OR10P1	SBK2	P0C263	419
OR10P1	CYP27C1	Q4G0S4	417
OR10P1	MYBPHL	A2RUH7	400
OR10P1	SQOR	Q9Y6N5	356
OR10P1	TAS2R1	Q9NYW7	329
OR10P1	SLC39A5	Q6ZMH5	314
OR10P1	ZRANB2	O95218	295
OR10P1	SBK3	P0C264	290
OR10P1	APOF	Q13790	274
OR10P1	RD3L	P0DJH9	270
OR10P1	CHRNE	Q04844	265
OR10P1	SMCO1	Q147U7	247
OR10P1	PA2G4	Q9UQ80	239

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	1
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

191 predictions. Top by Δscore:

Variant	Effect	Δscore
12:55637260:A:G	donor_gain	0.8500
12:55637402:A:AG	acceptor_gain	0.7400
12:55637403:G:GG	acceptor_gain	0.7400
12:55637194:GAT:G	donor_gain	0.6800
12:55637403:GCC:G	acceptor_gain	0.6300
12:55637403:GC:G	acceptor_gain	0.6100
12:55637555:ATCCT:A	acceptor_gain	0.6000
12:55637327:G:GG	donor_gain	0.5700
12:55636981:G:GA	donor_gain	0.5600
12:55637044:C:A	donor_gain	0.5600
12:55637017:C:G	donor_gain	0.5400
12:55637322:CCATG:C	donor_loss	0.5200
12:55637323:CATGG:C	donor_loss	0.5200
12:55637324:ATGG:A	donor_loss	0.5200
12:55637325:TG:T	donor_loss	0.5200
12:55637326:GG:G	donor_loss	0.5200
12:55637327:GTG:G	donor_loss	0.5200
12:55637328:T:G	donor_loss	0.5200
12:55637329:GGGT:G	donor_loss	0.5200
12:55637330:GGT:G	donor_loss	0.5200
12:55637331:G:A	donor_loss	0.5200
12:55637650:T:TA	acceptor_gain	0.5200
12:55637332:T:A	donor_loss	0.5100
12:55637399:C:CA	acceptor_gain	0.5100
12:55637196:T:G	donor_gain	0.4800
12:55637200:C:A	donor_gain	0.4600
12:55637532:T:TA	acceptor_gain	0.4300
12:55637403:GCCA:G	acceptor_gain	0.4200
12:55637403:GCCAC:G	acceptor_gain	0.4200
12:55636980:T:TA	donor_gain	0.4100

AlphaMissense

2012 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:55637660:A:C	S257R	0.971
12:55637662:C:A	S257R	0.971
12:55637662:C:G	S257R	0.971
12:55637423:T:C	F178L	0.957
12:55637425:T:A	F178L	0.957
12:55637425:T:G	F178L	0.957
12:55636925:T:C	F12L	0.955
12:55636927:C:A	F12L	0.955
12:55636927:C:G	F12L	0.955
12:55637717:A:C	S276R	0.955
12:55637719:T:A	S276R	0.955
12:55637719:T:G	S276R	0.955
12:55636940:T:C	F17L	0.953
12:55636942:C:A	F17L	0.953
12:55636942:C:G	F17L	0.953
12:55637396:T:C	F169L	0.945
12:55637398:T:A	F169L	0.945
12:55637398:T:G	F169L	0.945
12:55637648:T:C	F253L	0.942
12:55637650:T:A	F253L	0.942
12:55637650:T:G	F253L	0.942
12:55637429:T:A	C180S	0.939
12:55637430:G:C	C180S	0.939
12:55637645:T:C	F252L	0.937
12:55637647:C:A	F252L	0.937
12:55637647:C:G	F252L	0.937
12:55637384:T:C	F165L	0.933
12:55637386:C:A	F165L	0.933
12:55637386:C:G	F165L	0.933
12:55637259:G:C	R123P	0.932

dbSNP variants (sampled 300 via entrez): RS1000076142 (12:55635803 A>T), RS1000126683 (12:55635492 C>A), RS1001937327 (12:55636606 A>G), RS1003925264 (12:55636186 C>T), RS1003989581 (12:55636742 C>A,T), RS1004380524 (12:55635896 A>C), RS1004506907 (12:55637566 C>T), RS1004982464 (12:55637273 T>G), RS1009080528 (12:55638325 A>G), RS1010529075 (12:55634963 T>C), RS1010557655 (12:55638241 C>A,T), RS1012542484 (12:55637724 T>A), RS1013545879 (12:55636038 T>C), RS1015819910 (12:55637279 C>A,T), RS1017101755 (12:55636220 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002238_5	Contrast sensitivity	5.000000e-06
GCST005519_1	Heart rate response to beta blockers	2.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005419	contrast sensitivity measurement
EFO:0007766	response to beta blocker

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol S	increases methylation	1
Folic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.