OR10Q1

Summary

OR10Q1 (olfactory receptor family 10 subfamily Q member 1, HGNC:15134) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 10Q1 (Q8NGQ4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219960 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_001004471

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15134
Approved symbol	OR10Q1
Name	olfactory receptor family 10 subfamily Q member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000180475
Ensembl biotype	protein_coding
Entrez	219960

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000316770

RefSeq mRNA: 1 — MANE Select: NM_001004471 NM_001004471

CCDS: CCDS31547

Canonical transcript exons

ENST00000316770 — 1 exons

Exon	Start	End
ENSE00001256103	58227882	58228918

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 47.56.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	47.56	gold quality
colonic epithelium	UBERON:0000397	42.12	gold quality
apex of heart	UBERON:0002098	40.88	silver quality
ventricular zone	UBERON:0003053	40.53	silver quality
granulocyte	CL:0000094	37.12	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
placenta	UBERON:0001987	35.31	gold quality
muscle of leg	UBERON:0001383	34.51	silver quality
gastrocnemius	UBERON:0001388	34.48	silver quality
subcutaneous adipose tissue	UBERON:0002190	33.45	gold quality
thoracic mammary gland	UBERON:0005200	32.49	silver quality
adipose tissue	UBERON:0001013	32.30	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
urinary bladder	UBERON:0001255	31.26	silver quality
omental fat pad	UBERON:0010414	31.19	silver quality
rectum	UBERON:0001052	31.00	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
prefrontal cortex	UBERON:0000451	30.45	gold quality
heart left ventricle	UBERON:0002084	29.43	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	29.24	silver quality
smooth muscle tissue	UBERON:0001135	29.00	silver quality
duodenum	UBERON:0002114	28.14	gold quality
saliva-secreting gland	UBERON:0001044	27.94	silver quality
minor salivary gland	UBERON:0001830	27.82	silver quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.55	gold quality
tonsil	UBERON:0002372	27.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10q12	ENSMUSG00000047207
mus_musculus	Or10q1	ENSMUSG00000050865
mus_musculus	Or10q1b	ENSMUSG00000051156

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 10Q1 — Q8NGQ4 (reviewed: Q8NGQ4)

Alternative names: Olfactory receptor OR11-233

All UniProt accessions (1): Q8NGQ4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004471* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGQ4-F1	86.56	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 101–194

Glycosylation sites (1): 9

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

76 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10Q1	ZNF676	Q8N7Q3	371
OR10Q1	CORO7	P57737	359
OR10Q1	PCDHGB4	Q9UN71	310
OR10Q1	DNAH8	Q96JB1	291
OR10Q1	TRIM58	Q8NG06	290
OR10Q1	VASN	Q6EMK4	286
OR10Q1	KIF23	Q02241	283
OR10Q1	ASPM	Q8IZT6	257
OR10Q1	A0A0A6YYL4	A0A0A6YYL4	253
OR10Q1	VSX1	Q9NZR4	249
OR10Q1	CORIN	Q9Y5Q5	233
OR10Q1	ZNF429	Q86V71	224
OR10Q1	EXO1	Q9UQ84	219
OR10Q1	SH3PXD2A	Q5TCZ1	215
OR10Q1	OR51F2	Q8NH61	184

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95371, O95918, P0C629, P0C645, P0C7T2, P23266, P23275, P34984, P58181, P59922, Q13607, Q5JQS5, Q5TZ20, Q60883, Q60890, Q6IEZ7, Q6IF00, Q7TR96, Q7Z3T1, Q8N349, Q8N628, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

156 predictions. Top by Δscore:

Variant	Effect	Δscore
11:58228632:C:CT	donor_gain	0.9500
11:58228633:T:TT	donor_gain	0.9500
11:58228635:C:CT	donor_gain	0.9500
11:58228633:TAC:T	donor_gain	0.9400
11:58228631:A:AC	donor_gain	0.8900
11:58228356:C:CT	acceptor_gain	0.8400
11:58228636:CACGG:C	donor_gain	0.7300
11:58228634:A:AA	donor_gain	0.7000
11:58228256:A:AC	donor_gain	0.6800
11:58228257:C:CC	donor_gain	0.6800
11:58228207:G:C	acceptor_gain	0.6300
11:58228424:C:CT	donor_gain	0.6200
11:58228257:CGA:C	donor_gain	0.6100
11:58228719:C:CT	donor_gain	0.6100
11:58228428:C:CT	donor_gain	0.6000
11:58228446:G:C	donor_gain	0.5800
11:58228422:C:CA	donor_gain	0.5700
11:58228637:A:T	donor_gain	0.5600
11:58228252:G:A	donor_gain	0.5000
11:58228498:G:C	donor_gain	0.5000
11:58228636:C:CT	donor_gain	0.5000
11:58228217:C:CT	acceptor_gain	0.4900
11:58228344:CCTGG:C	acceptor_gain	0.4900
11:58228425:C:T	donor_gain	0.4700
11:58228215:C:CT	acceptor_gain	0.4600
11:58228258:G:C	donor_gain	0.4600
11:58228323:C:CT	acceptor_gain	0.4500
11:58228689:T:TA	donor_gain	0.4100
11:58228720:C:CT	donor_gain	0.4100
11:58228206:C:CT	acceptor_gain	0.4000

AlphaMissense

2076 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:58228360:A:C	F172L	0.908
11:58228360:A:T	F172L	0.908
11:58228362:A:G	F172L	0.908
11:58228828:A:C	F16L	0.902
11:58228828:A:T	F16L	0.902
11:58228830:A:G	F16L	0.902
11:58228330:G:C	F182L	0.869
11:58228330:G:T	F182L	0.869
11:58228332:A:G	F182L	0.869
11:58228093:G:C	S261R	0.867
11:58228093:G:T	S261R	0.867
11:58228095:T:G	S261R	0.867
11:58228252:G:C	S208R	0.834
11:58228252:G:T	S208R	0.834
11:58228254:T:G	S208R	0.834
11:58228372:G:C	F168L	0.832
11:58228372:G:T	F168L	0.832
11:58228374:A:G	F168L	0.832
11:58228813:G:C	F21L	0.813
11:58228813:G:T	F21L	0.813
11:58228815:A:G	F21L	0.813
11:58228537:G:C	S113R	0.810
11:58228537:G:T	S113R	0.810
11:58228539:T:G	S113R	0.810
11:58228822:G:C	F18L	0.800
11:58228822:G:T	F18L	0.800
11:58228824:A:G	F18L	0.800
11:58228310:A:T	V189D	0.799
11:58228510:C:A	M122I	0.773
11:58228510:C:G	M122I	0.773

dbSNP variants (sampled 300 via entrez): RS1000496803 (11:58227659 T>C), RS1002725719 (11:58230019 A>T), RS1004729493 (11:58227785 T>A), RS1006868909 (11:58229951 A>G,T), RS1008230960 (11:58228959 C>G,T), RS1008524409 (11:58229473 AATTG>A), RS1009291221 (11:58228094 C>T), RS1011296728 (11:58230869 C>T), RS1011890141 (11:58230775 T>C), RS1012339517 (11:58230016 T>A,C,G), RS1012804024 (11:58230435 A>G), RS1014981051 (11:58227806 G>A,T), RS1015762975 (11:58229483 A>T), RS1017813432 (11:58228984 A>C), RS1018286077 (11:58229178 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006919_4	Ability to confide in someone	9.000000e-08
GCST006923_2	Loneliness	3.000000e-06
GCST006924_11	Loneliness (MTAG)	8.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009592	social interaction measurement
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases mutagenesis	2
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.