OR10R2

Summary

OR10R2 (olfactory receptor family 10 subfamily R member 2, HGNC:14820) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 10R2 (Q8NGX6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 343406 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 40 total
• MANE Select transcript: NM_001395749

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14820
Approved symbol	OR10R2
Name	olfactory receptor family 10 subfamily R member 2
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	OR10R2Q
Ensembl gene	ENSG00000198965
Ensembl biotype	protein_coding
Entrez	343406

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641067, ENST00000641400

RefSeq mRNA: 2 — MANE Select: NM_001395749 NM_001004472, NM_001395749

CCDS: CCDS91076

Canonical transcript exons

ENST00000641067 — 2 exons

Exon	Start	End
ENSE00003812664	158472220	158472352
ENSE00003813259	158479938	158480936

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 38.38.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.38	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.46	gold quality
bone marrow	UBERON:0002371	32.88	gold quality
muscle tissue	UBERON:0002385	32.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	29.56	gold quality
monocyte	CL:0000576	29.40	gold quality
leukocyte	CL:0000738	29.24	gold quality
calcaneal tendon	UBERON:0003701	29.18	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.62	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.79	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.22	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.06	gold quality
pancreas	UBERON:0001264	24.14	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10R2 — Q8NGX6 (reviewed: Q8NGX6)

Alternative names: Olfactory receptor OR1-8

All UniProt accessions (2): A0A126GVZ9, A0A286YEZ2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001004472, NP_001382678* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX6-F1	82.20	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 117–209

Glycosylation sites (1): 25

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, chr1q23

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

94 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10R2	VRTN	Q9H8Y1	447
OR10R2	NCR1	O76036	410
OR10R2	MFAP4	P55083	404
OR10R2	FBP1	P09467	378
OR10R2	L1TD1	Q5T7N2	377
OR10R2	TRAPPC8	Q9Y2L5	368
OR10R2	CHRNA6	Q15825	322
OR10R2	ARF1	P10947	311
OR10R2	TOX2	Q96NM4	304
OR10R2	SH3BP5	O60239	302
OR10R2	SLC44A1	Q8WWI5	295
OR10R2	CD1A	P06126	271
OR10R2	ANOS1	P23352	256
OR10R2	SPTA1	P02549	251
OR10R2	DTX1	Q86Y01	243

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: B2RN74, O43869, O60431, P0C617, P23272, P47883, Q5JRS4, Q6IF36, Q6IFN5, Q8NG75, Q8NG78, Q8NG84, Q8NG94, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGC7, Q8NGC9, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGG7, Q8NGH3, Q8NGI9, Q8NGK9, Q8NGL3, Q8NGP2, Q8NGQ1, Q8NGQ3, Q8NGR1, Q8NGR2, Q8NGS6, Q8NGT5, Q8NGV5, Q8NGW1, Q8NGW6, Q8NGX6, Q8NGX8, Q8NGY0, Q8NGZ0

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

290 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158480598:A:AG	acceptor_gain	0.7800
1:158480598:ATTCT:A	acceptor_gain	0.7400
1:158479980:C:G	donor_gain	0.6700
1:158480591:T:G	acceptor_gain	0.6500
1:158480602:T:TA	acceptor_gain	0.6500
1:158480599:T:G	acceptor_gain	0.6400
1:158480629:C:G	donor_gain	0.6400
1:158480207:G:GT	donor_gain	0.6300
1:158480590:A:AG	acceptor_gain	0.6100
1:158480595:T:TA	acceptor_gain	0.6100
1:158480532:A:AG	donor_gain	0.6000
1:158479964:C:A	donor_gain	0.5800
1:158480674:GT:G	donor_gain	0.5800
1:158480518:T:G	donor_gain	0.5600
1:158480010:C:G	donor_gain	0.5500
1:158480412:GTA:G	donor_gain	0.5500
1:158480022:G:GG	donor_gain	0.5400
1:158480673:A:AG	donor_gain	0.5400
1:158480023:T:TA	donor_gain	0.5200
1:158480024:A:AA	donor_gain	0.5200
1:158480428:TCAGC:T	acceptor_gain	0.5200
1:158480429:CAGCC:C	acceptor_gain	0.5200
1:158480582:T:TA	acceptor_gain	0.5200
1:158480041:ATCT:A	donor_gain	0.5100
1:158480603:GAGG:G	acceptor_loss	0.5100
1:158480635:G:T	donor_gain	0.5100
1:158480544:G:GT	donor_gain	0.5000
1:158480561:G:GA	donor_gain	0.5000
1:158480430:AGCC:A	acceptor_gain	0.4900
1:158480225:T:TA	donor_gain	0.4800

AlphaMissense

2117 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158480302:G:C	R142P	0.982
1:158480808:A:C	S311R	0.981
1:158480810:C:A	S311R	0.981
1:158480810:C:G	S311R	0.981
1:158479971:T:C	F32L	0.964
1:158479973:C:A	F32L	0.964
1:158479973:C:G	F32L	0.964
1:158479986:T:C	F37L	0.960
1:158479988:T:A	F37L	0.960
1:158479988:T:G	F37L	0.960
1:158480310:G:C	A145P	0.958
1:158480301:C:A	R142S	0.956
1:158480291:G:A	M138I	0.953
1:158480291:G:C	M138I	0.953
1:158480291:G:T	M138I	0.953
1:158480795:C:A	N306K	0.952
1:158480795:C:G	N306K	0.952
1:158480311:C:A	A145D	0.941
1:158480439:T:C	F188L	0.940
1:158480441:T:A	F188L	0.940
1:158480441:T:G	F188L	0.940
1:158479972:T:C	F32S	0.939
1:158480645:A:C	K256N	0.939
1:158480645:A:T	K256N	0.939
1:158480292:G:C	G139R	0.934
1:158480427:T:C	F184L	0.934
1:158480429:C:A	F184L	0.934
1:158480429:C:G	F184L	0.934
1:158480114:G:A	M79I	0.932
1:158480114:G:C	M79I	0.932

dbSNP variants (sampled 300 via entrez): RS1000542744 (1:158478404 T>C), RS1000645129 (1:158470948 T>C), RS1000919277 (1:158479186 T>A,C), RS1001085128 (1:158477425 C>T), RS1001087766 (1:158473538 A>G), RS1001099535 (1:158476579 A>G,T), RS1001266515 (1:158479418 C>A), RS1001817233 (1:158477028 C>T), RS1001932777 (1:158476807 C>T), RS1002320731 (1:158472198 A>C), RS1002394865 (1:158471901 T>A), RS1002407732 (1:158471375 C>A,T), RS1002658176 (1:158473420 CTGTTGTAT>C), RS1002759434 (1:158478587 A>C,G), RS1003015757 (1:158473172 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation	1
Endosulfan	decreases expression, decreases reaction	1
Tetrachlorodibenzodioxin	decreases reaction, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.