OR10S1

Summary

OR10S1 (olfactory receptor family 10 subfamily S member 1, HGNC:14807) is a protein-coding gene on chromosome 11q24.1, encoding Olfactory receptor 10S1 (Q8NGN2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219873 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_001004474

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14807
Approved symbol	OR10S1
Name	olfactory receptor family 10 subfamily S member 1
Location	11q24.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196248
Ensembl biotype	protein_coding
Entrez	219873

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641123

RefSeq mRNA: 1 — MANE Select: NM_001004474 NM_001004474

CCDS: CCDS31701

Canonical transcript exons

ENST00000641123 — 1 exons

Exon	Start	End
ENSE00002143636	123976661	123977781

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 37.20.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.82	gold quality
pancreas	UBERON:0001264	28.54	gold quality
body of pancreas	UBERON:0001150	28.46	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
leukocyte	CL:0000738	26.54	gold quality
monocyte	CL:0000576	26.43	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.18	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.93	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
adrenal tissue	UBERON:0018303	24.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10s1	ENSMUSG00000049010
rattus_norvegicus	Or10s1	ENSRNOG00000058978

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10S1 — Q8NGN2 (reviewed: Q8NGN2)

Alternative names: Olfactory receptor OR11-279

All UniProt accessions (1): A0A286YF54

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004474* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN2-F1	85.13	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 111–203

Glycosylation sites (1): 18

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10S1	MSANTD1	Q6ZTZ1	507
OR10S1	LDLRAD1	Q5T700	504
OR10S1	ZNF606	Q8WXB4	447
OR10S1	SLCO1B7	G3V0H7	447
OR10S1	ZNF99	A8MXY4	446
OR10S1	IRGQ	Q8WZA9	444
OR10S1	RHBDL1	O75783	434
OR10S1	PPEF2	O14830	423
OR10S1	PYDC2	Q56P42	394
OR10S1	LCE1A	Q5T7P2	390
OR10S1	SUGP2	Q8IX01	379
OR10S1	TPTE2	Q6XPS3	368
OR10S1	AP3S2	P59780	367
OR10S1	DHX34	Q14147	348
OR10S1	EFHC1	Q5JVL4	335

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR10S1	ABCC4	psi-mi:“MI:0914”(association)	0.350

BioGRID (7): SLC12A6 (Affinity Capture-MS), TMEM179B (Affinity Capture-MS), SLC44A5 (Affinity Capture-MS), SARAF (Affinity Capture-MS), ABCC4 (Affinity Capture-MS), SLC12A4 (Affinity Capture-MS), FAM63A (Affinity Capture-MS)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

204 predictions. Top by Δscore:

Variant	Effect	Δscore
11:123976975:CACAG:C	acceptor_gain	0.6900
11:123977601:TCAA:T	donor_gain	0.5900
11:123976977:CAG:C	acceptor_gain	0.5800
11:123976984:CACGA:C	acceptor_gain	0.5700
11:123976996:G:C	acceptor_gain	0.5700
11:123976994:A:C	acceptor_gain	0.5500
11:123976850:G:A	donor_gain	0.5400
11:123976986:CGA:C	acceptor_gain	0.5400
11:123976988:A:AC	acceptor_gain	0.5300
11:123976778:C:CT	acceptor_gain	0.5200
11:123976846:T:TA	donor_gain	0.5200
11:123976979:G:C	donor_gain	0.5200
11:123976996:G:GC	acceptor_gain	0.5100
11:123977375:A:AC	donor_gain	0.5100
11:123976994:A:AC	acceptor_gain	0.5000
11:123976843:AGCT:A	donor_gain	0.4800
11:123977628:CCA:C	donor_gain	0.4700
11:123976784:G:GC	acceptor_gain	0.4600
11:123977198:ATGG:A	donor_gain	0.4600
11:123977628:C:CT	donor_gain	0.4200
11:123976784:G:C	acceptor_gain	0.4100
11:123976857:T:C	donor_gain	0.4100
11:123976980:C:CC	acceptor_gain	0.4100
11:123977198:ATGGC:A	donor_gain	0.4100
11:123977592:CGGT:C	donor_gain	0.4100
11:123977593:GGTG:G	donor_gain	0.4100
11:123976987:G:T	acceptor_gain	0.4000
11:123977022:AG:A	donor_gain	0.4000
11:123977486:C:CC	acceptor_gain	0.4000
11:123977546:C:CC	acceptor_gain	0.4000

AlphaMissense

2097 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:123977158:G:C	F178L	0.886
11:123977158:G:T	F178L	0.886
11:123977160:A:G	F178L	0.886
11:123977617:G:C	F25L	0.827
11:123977617:G:T	F25L	0.827
11:123977619:A:G	F25L	0.827
11:123977338:G:C	F118L	0.816
11:123977338:G:T	F118L	0.816
11:123977340:A:G	F118L	0.816
11:123977545:G:C	S49R	0.777
11:123977545:G:T	S49R	0.777
11:123977547:T:G	S49R	0.777
11:123977323:G:C	S123R	0.770
11:123977323:G:T	S123R	0.770
11:123977325:T:G	S123R	0.770
11:123977119:G:C	F191L	0.763
11:123977119:G:T	F191L	0.763
11:123977121:A:G	F191L	0.763
11:123976936:G:C	F252L	0.754
11:123976936:G:T	F252L	0.754
11:123976938:A:G	F252L	0.754
11:123977467:G:C	F75L	0.748
11:123977467:G:T	F75L	0.748
11:123977469:A:G	F75L	0.748
11:123977368:A:C	F108L	0.738
11:123977368:A:T	F108L	0.738
11:123977370:A:G	F108L	0.738
11:123977350:C:A	Q114H	0.737
11:123977350:C:G	Q114H	0.737
11:123977116:G:C	F192L	0.734

dbSNP variants (sampled 300 via entrez): RS1001193742 (11:123978441 C>G), RS1001832785 (11:123978710 C>T), RS1002891773 (11:123979604 G>A), RS1004516753 (11:123978493 G>A), RS1004827669 (11:123978818 T>C), RS1005267512 (11:123979129 C>T), RS1006514452 (11:123977330 A>G), RS1006954352 (11:123977616 A>G), RS1007392388 (11:123977837 C>T), RS1008575611 (11:123979424 C>T), RS1009733807 (11:123979570 G>A,T), RS1009805667 (11:123979770 CA>C), RS1010144041 (11:123978312 T>G), RS1010995035 (11:123979548 C>T), RS1011045648 (11:123979280 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.