OR10T2

Summary

OR10T2 (olfactory receptor family 10 subfamily T member 2, HGNC:14816) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 10T2 (Q8NGX3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 128360 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001004475

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14816
Approved symbol	OR10T2
Name	olfactory receptor family 10 subfamily T member 2
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186306
Ensembl biotype	protein_coding
Entrez	128360

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000334438

RefSeq mRNA: 1 — MANE Select: NM_001004475 NM_001004475

CCDS: CCDS30895

Canonical transcript exons

ENST00000334438 — 1 exons

Exon	Start	End
ENSE00001338858	158398522	158399466

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 56.22.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.22	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.91	gold quality
leukocyte	CL:0000738	28.80	gold quality
liver	UBERON:0002107	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.89	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.13	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.82	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	24.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 10T2 — Q8NGX3 (reviewed: Q8NGX3)

Alternative names: Olfactory receptor OR1-3

All UniProt accessions (2): Q8NGX3, A0A126GV74

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004475* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 6, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX3-F1	85.00	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ARID5B_TARGET_GENES, RAG1_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10T2	TMCO2	Q7Z6W1	540
OR10T2	ACSM6	Q6P461	506
OR10T2	MSLNL	Q96KJ4	476
OR10T2	KIRREL1	Q96J84	435
OR10T2	CEACAM16	Q2WEN9	348
OR10T2	CEP128	Q6ZU80	336
OR10T2	BHLHE23	Q8NDY6	322
OR10T2	CACNG3	O60359	311
OR10T2	ABCA10	Q8WWZ4	308
OR10T2	CPVL	Q9H3G5	307
OR10T2	ASCC3	Q8N3C0	290
OR10T2	TRAPPC9	Q96Q05	270
OR10T2	KCNJ10	P78508	260
OR10T2	HTR5A	P47898	253
OR10T2	CNGB3	Q9NQW8	251

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NCV1, A6NF89, A6NJZ3, A6NL08, A6NM76, O95221, P0C7N1, P0C7N5, P37070, P37071, P37072, Q15617, Q60886, Q6IEU7, Q8N127, Q8NGE1, Q8NGG0, Q8NGG8, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGS9, Q8NGT0, Q8NGT1, Q8NGX3, Q8NH01, Q8NH10, Q8NH51, Q8NH69, Q8VEW5, Q8VF65, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3, Q8VFK2, Q8VG02, Q8VG03, Q8VG04, Q8VG07

Diamond homologs: A3KFT3, A4D2G3, O43749, O60412, O76000, O76001, O76002, O95006, O95047, O95371, O95918, P0C626, P23266, P23269, P23272, P23273, P23274, P23275, P30953, P30955, P34982, P34984, P34986, P58173, P58181, P59922, P70526, Q13606, Q13607, Q15617, Q15619, Q5TZ20, Q60879, Q60890, Q6IEU7, Q6IF42, Q6UXT6, Q8N628, Q8NGA1, Q8NGC9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

179 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158399037:CCA:C	donor_gain	0.7500
1:158398710:C:CT	acceptor_gain	0.7400
1:158398809:CA:C	acceptor_gain	0.7300
1:158398810:A:C	acceptor_gain	0.7200
1:158398711:A:C	acceptor_gain	0.7000
1:158399098:G:C	donor_gain	0.7000
1:158398800:C:CC	acceptor_gain	0.6500
1:158398817:A:C	acceptor_gain	0.6200
1:158399286:A:AC	donor_gain	0.5800
1:158399287:C:CC	donor_gain	0.5800
1:158398595:C:CC	acceptor_gain	0.5700
1:158398726:C:CT	acceptor_gain	0.5600
1:158398944:CC:C	acceptor_gain	0.5500
1:158398945:CC:C	acceptor_gain	0.5500
1:158398808:CCA:C	acceptor_gain	0.5400
1:158398782:TCTTC:T	acceptor_gain	0.5200
1:158398810:A:AC	acceptor_gain	0.5200
1:158398795:GTTAA:G	acceptor_gain	0.5100
1:158398709:CCA:C	acceptor_gain	0.4900
1:158398781:ATCTT:A	acceptor_gain	0.4900
1:158398710:C:T	acceptor_gain	0.4800
1:158398594:A:AC	acceptor_gain	0.4600
1:158398711:A:AC	acceptor_gain	0.4500
1:158398797:TAA:T	acceptor_gain	0.4500
1:158398815:A:AC	acceptor_gain	0.4500
1:158398796:TTAA:T	acceptor_gain	0.4400
1:158398798:AA:A	acceptor_gain	0.4400
1:158398817:A:AC	acceptor_gain	0.4300
1:158398815:A:C	acceptor_gain	0.4200
1:158399288:A:C	donor_gain	0.4200

AlphaMissense

2040 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158399428:G:C	F13L	0.966
1:158399428:G:T	F13L	0.966
1:158399430:A:G	F13L	0.966
1:158398960:A:C	F169L	0.962
1:158398960:A:T	F169L	0.962
1:158398962:A:G	F169L	0.962
1:158399413:G:C	F18L	0.952
1:158399413:G:T	F18L	0.952
1:158399415:A:G	F18L	0.952
1:158398913:A:T	V185D	0.947
1:158399429:A:G	F13S	0.945
1:158398930:G:C	F179L	0.929
1:158398930:G:T	F179L	0.929
1:158398932:A:G	F179L	0.929
1:158398928:C:G	C180S	0.920
1:158398929:A:T	C180S	0.920
1:158398961:A:C	F169C	0.916
1:158398928:C:T	C180Y	0.908
1:158398961:A:G	F169S	0.908
1:158399429:A:C	F13C	0.902
1:158398594:A:C	S291R	0.899
1:158398594:A:T	S291R	0.899
1:158398596:T:G	S291R	0.899
1:158398855:G:C	S204R	0.899
1:158398855:G:T	S204R	0.899
1:158398857:T:G	S204R	0.899
1:158399380:A:C	F29L	0.895
1:158399380:A:T	F29L	0.895
1:158399382:A:G	F29L	0.895
1:158399152:G:C	F105L	0.894

dbSNP variants (sampled 300 via entrez): RS1000062398 (1:158400364 A>T), RS1000277821 (1:158399945 G>A), RS1001075691 (1:158399413 G>A,T), RS1004015168 (1:158401399 C>A), RS1004701314 (1:158401035 G>A), RS1004728413 (1:158401193 T>C,G), RS1005102705 (1:158400860 G>A), RS1005966207 (1:158399620 T>C), RS1006099144 (1:158399880 G>A), RS1008569137 (1:158400678 G>A), RS1009820365 (1:158400351 G>A), RS1011480530 (1:158398339 A>C,G), RS1013021605 (1:158399910 C>A), RS1013158022 (1:158399677 A>G), RS1013491121 (1:158401260 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.