OR10V1

Summary

OR10V1 (olfactory receptor family 10 subfamily V member 1, HGNC:15136) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 10V1 (Q8NGI7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390201 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001005324

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15136
Approved symbol	OR10V1
Name	olfactory receptor family 10 subfamily V member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172289
Ensembl biotype	protein_coding
Entrez	390201

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000307552

RefSeq mRNA: 1 — MANE Select: NM_001005324 NM_001005324

CCDS: CCDS31565

Canonical transcript exons

ENST00000307552 — 1 exons

Exon	Start	End
ENSE00001170605	59712916	59713845

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 38.93.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.93	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
right coronary artery	UBERON:0001625	36.30	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	33.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.97	gold quality
lymph node	UBERON:0000029	27.57	gold quality
calcaneal tendon	UBERON:0003701	27.40	gold quality
leukocyte	CL:0000738	27.32	gold quality
monocyte	CL:0000576	27.29	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.35	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
ectocervix	UBERON:0012249	25.64	gold quality
uterine cervix	UBERON:0000002	25.33	gold quality
pancreas	UBERON:0001264	24.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10v1	ENSMUSG00000060878
rattus_norvegicus	Or10v1	ENSRNOG00000021050

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 10V1 — Q8NGI7 (reviewed: Q8NGI7)

Alternative names: Olfactory receptor OR11-256

All UniProt accessions (1): Q8NGI7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005324* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGI7-F1	88.41	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10V1	ORMDL2	Q53FV1	521
OR10V1	FAM131A	Q6UXB0	479
OR10V1	FAM174A	Q8TBP5	447
OR10V1	USP17L19	D6RCP7	400
OR10V1	USP17L15	C9J2P7	398
OR10V1	ZNF232	Q9UNY5	397
OR10V1	ZNF804B	A4D1E1	395
OR10V1	APCDD1L	Q8NCL9	380
OR10V1	TAS2R16	Q9NYV7	359
OR10V1	ARK2C	Q6ZSG1	348
OR10V1	NYNRIN	Q9P2P1	336
OR10V1	RTL3	Q8N8U3	323
OR10V1	RPS6KC1	Q96S38	320
OR10V1	BEST3	Q8N1M1	313
OR10V1	GRID2IP	A4D2P6	311

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10V1 (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O60404, O76001, O76002, O76100, O95007, O95047, P0DMU2, P23269, P23271, P23272, P23274, P30953, P47884, P58170, P70526, Q15622, Q6IEZ7, Q6IF42, Q8N148, Q8NGA5, Q8NGA6, Q8NGC8, Q8NGI7, Q8NGS2, Q8NGS4, Q8NGX0, Q8NGX3, Q8NGX8, Q8NGZ5, Q8NH02, Q8NH04, Q8NH80, Q8NHA6, Q8VBW9, Q96R30, Q96R45, Q9GZK6, Q9GZM6

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

323 predictions. Top by Δscore:

Variant	Effect	Δscore
11:59713189:A:C	acceptor_gain	0.8400
11:59713177:C:CT	acceptor_gain	0.7300
11:59713170:TGG:T	acceptor_gain	0.6500
11:59713075:G:C	donor_gain	0.6400
11:59713048:G:C	donor_gain	0.6300
11:59713179:C:CT	acceptor_gain	0.6300
11:59713189:A:AC	acceptor_gain	0.6300
11:59713329:C:CT	acceptor_gain	0.6300
11:59712936:T:A	donor_gain	0.6100
11:59713331:T:TC	acceptor_gain	0.6100
11:59713089:A:AC	donor_gain	0.6000
11:59713090:C:CC	donor_gain	0.6000
11:59713144:C:CA	donor_gain	0.6000
11:59713180:G:T	acceptor_gain	0.6000
11:59713330:A:C	acceptor_gain	0.5900
11:59712971:C:CC	acceptor_gain	0.5800
11:59713188:CA:C	acceptor_gain	0.5700
11:59713325:TCATC:T	acceptor_gain	0.5700
11:59713555:T:TA	donor_gain	0.5700
11:59713108:G:C	donor_gain	0.5600
11:59713337:C:CT	acceptor_gain	0.5600
11:59713173:C:CC	acceptor_gain	0.5500
11:59713293:C:CC	acceptor_gain	0.5500
11:59713333:G:GC	acceptor_gain	0.5500
11:59713137:G:A	donor_gain	0.5400
11:59713250:G:C	donor_gain	0.5300
11:59713333:G:C	acceptor_gain	0.5300
11:59712967:CAAA:C	acceptor_gain	0.5200
11:59713019:G:C	donor_gain	0.5200
11:59713102:C:CT	donor_gain	0.5200

AlphaMissense

2016 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:59713312:G:C	F178L	0.810
11:59713312:G:T	F178L	0.810
11:59713314:A:G	F178L	0.810
11:59713339:G:C	F169L	0.800
11:59713339:G:T	F169L	0.800
11:59713341:A:G	F169L	0.800
11:59713732:G:C	S38R	0.774
11:59713732:G:T	S38R	0.774
11:59713734:T:G	S38R	0.774
11:59713795:G:C	F17L	0.755
11:59713795:G:T	F17L	0.755
11:59713797:A:G	F17L	0.755
11:59713762:A:C	F28L	0.716
11:59713762:A:T	F28L	0.716
11:59713764:A:G	F28L	0.716
11:59713075:G:C	S257R	0.711
11:59713075:G:T	S257R	0.711
11:59713077:T:G	S257R	0.711
11:59713810:A:C	F12L	0.705
11:59713810:A:T	F12L	0.705
11:59713812:A:G	F12L	0.705
11:59713537:A:C	F103L	0.698
11:59713537:A:T	F103L	0.698
11:59713539:A:G	F103L	0.698
11:59713351:G:C	F165L	0.687
11:59713351:G:T	F165L	0.687
11:59713353:A:G	F165L	0.687
11:59713753:G:C	F31L	0.666
11:59713753:G:T	F31L	0.666
11:59713755:A:G	F31L	0.666

dbSNP variants (sampled 300 via entrez): RS1000361572 (11:59712516 C>T), RS1000553492 (11:59714068 G>GA), RS1001479678 (11:59713134 C>T), RS1004673408 (11:59713429 C>G), RS1005809040 (11:59714737 G>A), RS1006110397 (11:59714394 G>A,C,T), RS1006149008 (11:59713648 C>T), RS1006541262 (11:59713912 G>A,T), RS1008205289 (11:59712964 C>A,T), RS1009763581 (11:59712502 G>A,T), RS1009919403 (11:59712440 G>A,T), RS1010122691 (11:59712858 G>T), RS1010978285 (11:59715475 T>C), RS1011508006 (11:59715349 C>A), RS1013067491 (11:59715003 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.