OR10W1

Summary

OR10W1 (olfactory receptor family 10 subfamily W member 1, HGNC:15139) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 10W1 (Q8NGF6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81341 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 45 total
• MANE Select transcript: NM_207374

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15139
Approved symbol	OR10W1
Name	olfactory receptor family 10 subfamily W member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172772
Ensembl biotype	protein_coding
Entrez	81341

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000395079

RefSeq mRNA: 1 — MANE Select: NM_207374 NM_207374

CCDS: CCDS7968

Canonical transcript exons

ENST00000395079 — 1 exons

Exon	Start	End
ENSE00001520516	58266792	58268260

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 39.52.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	39.52	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
granulocyte	CL:0000094	36.02	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.06	gold quality
muscle tissue	UBERON:0002385	32.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
tonsil	UBERON:0002372	30.96	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
leukocyte	CL:0000738	29.70	gold quality
monocyte	CL:0000576	29.32	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.89	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
urinary bladder	UBERON:0001255	26.95	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
muscle of leg	UBERON:0001383	26.05	gold quality
blood	UBERON:0000178	26.04	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
pancreas	UBERON:0001264	25.54	gold quality
gastrocnemius	UBERON:0001388	24.79	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting OR10W1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-4797-3P	97.48	67.14	989
HSA-MIR-4264	96.35	64.76	1480
HSA-MIR-541-3P	96.07	66.11	1271
HSA-MIR-654-5P	96.07	66.18	1280
HSA-MIR-181C-3P	90.57	67.56	103

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10w1	ENSMUSG00000061387
mus_musculus	Or10w3	ENSMUSG00000109520
rattus_norvegicus	Or10w1	ENSRNOG00000063952

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 10W1 — Q8NGF6 (reviewed: Q8NGF6)

Alternative names: Olfactory receptor OR11-236

All UniProt accessions (1): Q8NGF6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_997257* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGF6-F1	85.84	0.44

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MIR96_5P, MIR1271_5P, MIR12133, MIR122B_3P, MIR21_3P

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1949 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10W1	SOWAHC	Q53LP3	476
OR10W1	FIBCD1	Q8N539	422
OR10W1	ZFAND5	O76080	394
OR10W1	ELSPBP1	Q96BH3	355
OR10W1	UQCRFS1	P47985	349
OR10W1	CYCS	P00001	349
OR10W1	CYC1	P08574	349
OR10W1	MT-CO1	P00395	349
OR10W1	MT-ATP6	P00846	349
OR10W1	MT-ND6	P03923	349
OR10W1	MT-ND1	P03886	349
OR10W1	MT-ND4L	P03901	349
OR10W1	MT-ND5	P03915	349
OR10W1	MT-CO2	P00403	349
OR10W1	MT-ND4	P03905	349
OR10W1	MT-CO3	P00414	349
OR10W1	MT-ND2	P03891	349
OR10W1	MT-ND3	P03897	349

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O60404, O76001, O76002, O95371, P23266, P23267, P30953, P34984, P58173, Q13607, Q5JQS5, Q60885, Q7Z3T1, Q8N148, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGF6, Q8NGN1, Q8NGQ2, Q8NGQ4, Q8NGT2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY1, Q8NGY5, Q8NGZ5, Q8NGZ6, Q8NHB1, Q8VGD6, Q96KK4, Q96R30, Q96R45, Q96R47, Q96R48

Diamond homologs: O43749, O60403, O60404, O95221, P0C626, P0C629, P0C7N1, P0C7N5, P23274, P30953, P30954, P30955, P34986, P58173, P58181, P70526, Q13606, Q15619, Q5JRS4, Q60880, Q60893, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NGA5, Q8NGA6, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGF6, Q8NGG0, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

75 predictions. Top by Δscore:

Variant	Effect	Δscore
11:58267222:C:CC	acceptor_gain	0.6700
11:58267219:CCA:C	acceptor_gain	0.5600
11:58267220:CAC:C	acceptor_gain	0.5600
11:58267239:G:GC	acceptor_gain	0.5500
11:58267232:G:C	acceptor_gain	0.5400
11:58268083:C:CT	donor_gain	0.5400
11:58268084:T:TT	donor_gain	0.5400
11:58267220:CA:C	acceptor_gain	0.5000
11:58267206:T:TG	acceptor_gain	0.4900
11:58267232:G:GC	acceptor_gain	0.4800
11:58267239:G:C	acceptor_gain	0.4800
11:58267242:G:GC	acceptor_gain	0.4800
11:58267455:A:T	acceptor_gain	0.4800
11:58267364:AATGC:A	donor_gain	0.4700
11:58267218:GCCA:G	acceptor_gain	0.4600
11:58267219:CCAC:C	acceptor_gain	0.4600
11:58267454:C:CT	acceptor_gain	0.4600
11:58267224:A:AC	acceptor_gain	0.4500
11:58267230:G:GC	acceptor_gain	0.4500
11:58267145:C:CT	acceptor_gain	0.4400
11:58267217:AGCCA:A	acceptor_gain	0.4400
11:58267221:AC:A	acceptor_loss	0.4300
11:58267222:CTAT:C	acceptor_loss	0.4300
11:58267223:T:C	acceptor_loss	0.4300
11:58267245:A:C	acceptor_gain	0.4200
11:58267132:A:AC	donor_gain	0.4100
11:58267242:G:C	acceptor_gain	0.3900
11:58267409:CAGT:C	acceptor_gain	0.3900
11:58267224:A:C	acceptor_gain	0.3800
11:58267207:T:A	acceptor_gain	0.3700

AlphaMissense

1975 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:58267394:G:C	F155L	0.869
11:58267394:G:T	F155L	0.869
11:58267396:A:G	F155L	0.869
11:58267382:G:C	F159L	0.858
11:58267382:G:T	F159L	0.858
11:58267384:A:G	F159L	0.858
11:58267355:G:C	F168L	0.843
11:58267355:G:T	F168L	0.843
11:58267357:A:G	F168L	0.843
11:58267352:A:C	F169L	0.841
11:58267352:A:T	F169L	0.841
11:58267354:A:G	F169L	0.841
11:58267790:G:C	S23R	0.823
11:58267790:G:T	S23R	0.823
11:58267792:T:G	S23R	0.823
11:58267850:A:C	F3L	0.818
11:58267850:A:T	F3L	0.818
11:58267852:A:G	F3L	0.818
11:58267335:A:T	V175D	0.777
11:58267802:G:C	F19L	0.777
11:58267802:G:T	F19L	0.777
11:58267804:A:G	F19L	0.777
11:58267559:A:C	S100R	0.760
11:58267559:A:T	S100R	0.760
11:58267561:T:G	S100R	0.760
11:58267126:A:G	C245R	0.703
11:58267433:A:C	S142R	0.699
11:58267433:A:T	S142R	0.699
11:58267435:T:G	S142R	0.699
11:58267674:A:T	I62K	0.699

dbSNP variants (sampled 300 via entrez): RS1000281604 (11:58269201 T>C), RS1000487399 (11:58269359 C>T), RS1001635963 (11:58268226 G>A), RS1001729499 (11:58268544 G>A), RS1001971611 (11:58269584 C>T), RS1002066302 (11:58269884 C>T), RS1005236808 (11:58270142 A>G), RS1006505813 (11:58268613 C>T), RS1006529658 (11:58266488 A>T), RS1007483070 (11:58268295 A>G), RS1008879373 (11:58269249 G>A), RS1010325310 (11:58268576 C>G,T), RS1010794175 (11:58268826 A>T), RS1010899885 (11:58266326 G>T), RS1012889723 (11:58266911 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006919_4	Ability to confide in someone	9.000000e-08
GCST006923_2	Loneliness	3.000000e-06
GCST006924_11	Loneliness (MTAG)	8.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009592	social interaction measurement
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.