OR10X1

Summary

OR10X1 (olfactory receptor family 10 subfamily X member 1, HGNC:14995) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 10X1 (Q8NGY0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 128367 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001004477

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14995
Approved symbol	OR10X1
Name	olfactory receptor family 10 subfamily X member 1
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000279111
Ensembl biotype	protein_coding
Entrez	128367

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000623167

RefSeq mRNA: 1 — MANE Select: NM_001004477 NM_001004477

Canonical transcript exons

ENST00000623167 — 1 exons

Exon	Start	End
ENSE00003786332	158578919	158579899

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.66.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	37.66	gold quality
bone marrow	UBERON:0002371	37.25	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.83	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
leukocyte	CL:0000738	30.03	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.62	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.85	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.16	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.20	gold quality
pancreas	UBERON:0001264	24.64	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10x4	ENSMUSG00000059503
mus_musculus	Or10x1	ENSMUSG00000066672
rattus_norvegicus	Or10x1	ENSRNOG00000066161
rattus_norvegicus	Or10x1b	ENSRNOG00000073698

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 10X1 — Q8NGY0 (reviewed: Q8NGY0)

Alternative names: Olfactory receptor OR1-14

All UniProt accessions (2): Q8NGY0, A0A126GWA4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Polymorphism. A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004477* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 4, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGY0-F1	86.72	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 113–205

Glycosylation sites (2): 21, 209

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, CHYLA_CBFA2T3_TARGETS_DN, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MAFG_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10X1	MAGEB16	A2A368	475
OR10X1	SLC22A24	Q8N4F4	434
OR10X1	ZNF117	Q03924	418
OR10X1	THAP12	O43422	379
OR10X1	CEP295	Q9C0D2	370
OR10X1	ACOT4	Q8N9L9	361
OR10X1	FAM187B	Q17R55	360
OR10X1	SLC22A10	Q63ZE4	350
OR10X1	LGI2	Q8N0V4	349
OR10X1	RNF145	Q96MT1	324
OR10X1	IQCJ-SCHIP1	B3KU38	318
OR10X1	SH3BP4	Q9P0V3	312
OR10X1	PRR22	Q8IZ63	311
OR10X1	CSMD2	Q7Z408	310
OR10X1	IGSF3	O75054	308

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: B2RN74, O43869, O60431, P0C617, P23272, P47883, Q5JRS4, Q6IF36, Q6IFN5, Q8NG75, Q8NG78, Q8NG84, Q8NG94, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGC7, Q8NGC9, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGG7, Q8NGH3, Q8NGI9, Q8NGK9, Q8NGL3, Q8NGP2, Q8NGQ1, Q8NGQ3, Q8NGR1, Q8NGR2, Q8NGS6, Q8NGT5, Q8NGV5, Q8NGW1, Q8NGW6, Q8NGX6, Q8NGX8, Q8NGY0, Q8NGZ0

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

167 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158579820:T:TA	donor_gain	1.0000
1:158579824:T:TA	donor_gain	0.9500
1:158579786:A:C	donor_gain	0.9300
1:158579586:T:TA	donor_gain	0.9200
1:158579781:TG:T	donor_gain	0.9100
1:158579181:G:GC	acceptor_gain	0.8600
1:158579764:C:CT	donor_gain	0.8500
1:158579179:CAG:C	acceptor_gain	0.7800
1:158579181:G:C	acceptor_gain	0.7500
1:158579582:T:TA	donor_gain	0.7300
1:158579725:GATTA:G	donor_loss	0.7300
1:158579726:ATTAC:A	donor_loss	0.7300
1:158579727:TTAC:T	donor_loss	0.7300
1:158579728:TAC:T	donor_loss	0.7300
1:158579729:ACCTG:A	donor_loss	0.7300
1:158579730:CCTG:C	donor_loss	0.7300
1:158579170:TC:T	acceptor_gain	0.7200
1:158579170:TCCT:T	acceptor_loss	0.7200
1:158579171:CC:C	acceptor_gain	0.7200
1:158579172:CTGA:C	acceptor_loss	0.7200
1:158579180:A:T	acceptor_gain	0.7200
1:158579731:C:G	donor_loss	0.7000
1:158579172:C:CC	acceptor_gain	0.6900
1:158579784:A:AC	donor_gain	0.6900
1:158579785:C:CC	donor_gain	0.6900
1:158579817:AATT:A	donor_gain	0.6900
1:158579604:T:TA	donor_gain	0.6700
1:158579277:CTGT:C	donor_gain	0.6400
1:158579724:AGATT:A	donor_loss	0.6100
1:158579661:C:CC	acceptor_gain	0.6000

AlphaMissense

2151 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158579801:A:C	F33L	0.897
1:158579801:A:T	F33L	0.897
1:158579803:A:G	F33L	0.897
1:158578991:G:C	F303L	0.886
1:158578991:G:T	F303L	0.886
1:158578993:A:G	F303L	0.886
1:158579816:G:C	F28L	0.882
1:158579816:G:T	F28L	0.882
1:158579818:A:G	F28L	0.882
1:158579552:C:A	Q116H	0.876
1:158579552:C:G	Q116H	0.876
1:158579096:A:C	F268L	0.844
1:158579096:A:T	F268L	0.844
1:158579098:A:G	F268L	0.844
1:158579321:G:C	F193L	0.844
1:158579321:G:T	F193L	0.844
1:158579323:A:G	F193L	0.844
1:158579768:A:C	F44L	0.842
1:158579768:A:T	F44L	0.842
1:158579770:A:G	F44L	0.842
1:158579348:G:C	F184L	0.830
1:158579348:G:T	F184L	0.830
1:158579350:A:G	F184L	0.830
1:158579598:A:G	L101P	0.830
1:158579616:G:T	P95H	0.827
1:158579360:G:C	F180L	0.810
1:158579360:G:T	F180L	0.810
1:158579362:A:G	F180L	0.810
1:158579318:G:C	F194L	0.801
1:158579318:G:T	F194L	0.801

dbSNP variants (sampled 300 via entrez): RS1000780176 (1:158580676 T>C), RS1002417621 (1:158579625 G>A,T), RS1004816770 (1:158581630 T>C), RS1004827880 (1:158579911 A>G), RS1004878822 (1:158579556 A>G), RS1005671998 (1:158578877 G>A), RS1006896865 (1:158580211 G>T), RS1010240525 (1:158580895 T>C), RS1010949879 (1:158578479 G>A,T), RS1012137146 (1:158581178 G>T), RS1012188059 (1:158580936 A>T), RS1014186445 (1:158581530 C>T), RS1014549215 (1:158581788 G>A), RS1014664766 (1:158581366 G>A,C), RS1014982179 (1:158581637 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST003542_29	Night sleep phenotypes	6.000000e-06
GCST90002385_98	High light scatter reticulocyte count	5.000000e-22
GCST90002396_146	Mean reticulocyte volume	2.000000e-25
GCST90002397_778	Mean spheric corpuscular volume	4.000000e-61
GCST90002405_87	Reticulocyte count	1.000000e-35

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.