OR11G2

Summary

OR11G2 (olfactory receptor family 11 subfamily G member 2, HGNC:15346) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 11G2 (Q8NGC1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390439 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001386033

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15346
Approved symbol	OR11G2
Name	olfactory receptor family 11 subfamily G member 2
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196832
Ensembl biotype	protein_coding
Entrez	390439

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641682, ENST00000641879

RefSeq mRNA: 2 — MANE Select: NM_001386033 NM_001005503, NM_001386033

CCDS: CCDS32032

Canonical transcript exons

ENST00000641879 — 2 exons

Exon	Start	End
ENSE00003811603	20190896	20191666
ENSE00003812222	20197434	20201075

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 74.35.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.35	gold quality
sural nerve	UBERON:0015488	43.69	gold quality
blood	UBERON:0000178	43.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	42.56	silver quality
granulocyte	CL:0000094	40.70	gold quality
ventricular zone	UBERON:0003053	39.91	gold quality
lower esophagus mucosa	UBERON:0035834	39.14	gold quality
stromal cell of endometrium	CL:0002255	39.07	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ganglionic eminence	UBERON:0004023	37.12	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	36.39	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
leukocyte	CL:0000738	35.35	gold quality
monocyte	CL:0000576	34.78	gold quality
apex of heart	UBERON:0002098	34.67	gold quality
muscle tissue	UBERON:0002385	34.46	gold quality
right coronary artery	UBERON:0001625	33.49	gold quality
prefrontal cortex	UBERON:0000451	32.50	gold quality
superior frontal gyrus	UBERON:0002661	32.08	gold quality
liver	UBERON:0002107	32.05	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
gall bladder	UBERON:0002110	30.72	gold quality
urinary bladder	UBERON:0001255	30.50	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	30.17	gold quality
islet of Langerhans	UBERON:0000006	29.21	gold quality
pancreas	UBERON:0001264	29.11	gold quality
lymph node	UBERON:0000029	28.74	gold quality
frontal cortex	UBERON:0001870	28.29	gold quality
calcaneal tendon	UBERON:0003701	28.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.89

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or11g1	ENSMUSG00000094692

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 11G2 — Q8NGC1 (reviewed: Q8NGC1)

Alternative names: Olfactory receptor OR14-34

All UniProt accessions (1): A0A126GWS8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005503, NP_001372962* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC1-F1	81.65	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 135–217

Glycosylation sites (1): 43

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

288 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR11G2	PRSS48	Q7RTY5	572
OR11G2	STPG1	Q5TH74	419
OR11G2	PRSS55	Q6UWB4	411
OR11G2	CRYBG2	Q8N1P7	395
OR11G2	ZKSCAN8	Q15776	377
OR11G2	MARCHF10	Q8NA82	371
OR11G2	WFDC3	Q8IUB2	370
OR11G2	SHROOM1	Q2M3G4	370
OR11G2	ZCCHC2	Q9C0B9	369
OR11G2	USF3	Q68DE3	367
OR11G2	RNASE13	Q5GAN3	359
OR11G2	AP5B1	Q2VPB7	350
OR11G2	TSC22D2	O75157	349
OR11G2	ZNF717	Q9BY31	348
OR11G2	SPICE1	Q8N0Z3	333

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR11G2	MLNR	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): SLC26A4 (Affinity Capture-MS), ESRRB (Affinity Capture-MS), MLNR (Affinity Capture-MS), HPCAL4 (Affinity Capture-MS)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95371, O95918, P0C629, P0C645, P0C7T2, P23266, P23275, P34984, P58181, P59922, Q13607, Q5JQS5, Q5TZ20, Q60883, Q60890, Q6IEZ7, Q6IF00, Q7TR96, Q7Z3T1, Q8N349, Q8N628, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

312 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20198056:A:G	acceptor_gain	0.8100
14:20198108:T:TA	acceptor_gain	0.7800
14:20198053:T:G	donor_gain	0.7300
14:20198094:G:A	acceptor_gain	0.7200
14:20198053:T:TG	donor_gain	0.7100
14:20198057:G:GG	acceptor_gain	0.7100
14:20198089:A:AG	acceptor_gain	0.7100
14:20198103:T:G	acceptor_gain	0.7100
14:20197513:G:T	donor_gain	0.6700
14:20198256:A:T	donor_gain	0.6500
14:20198093:T:TA	acceptor_gain	0.6400
14:20198207:GC:G	donor_gain	0.6400
14:20197657:GAGA:G	donor_gain	0.6200
14:20198050:GTCT:G	donor_gain	0.6200
14:20198051:TCTT:T	donor_gain	0.6200
14:20198089:ATTGT:A	acceptor_gain	0.6200
14:20198205:C:CA	acceptor_gain	0.6200
14:20198208:C:G	donor_gain	0.6200
14:20197512:G:GT	donor_gain	0.6100
14:20198102:A:AG	acceptor_gain	0.6100
14:20198126:TGAGG:T	acceptor_gain	0.6000
14:20198127:GAGGG:G	acceptor_gain	0.6000
14:20197660:A:G	donor_gain	0.5900
14:20198206:G:A	acceptor_gain	0.5900
14:20198222:T:G	donor_gain	0.5900
14:20198091:T:A	acceptor_gain	0.5800
14:20198228:G:GT	donor_gain	0.5800
14:20197625:T:G	donor_gain	0.5700
14:20198089:ATT:A	acceptor_gain	0.5700
14:20198090:T:G	acceptor_gain	0.5700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000184964 (14:20191227 A>G), RS1000237435 (14:20191585 C>G), RS1000467115 (14:20200672 G>T), RS1000737366 (14:20188987 T>A), RS1001191102 (14:20189216 G>A), RS1001334270 (14:20198529 C>A,G), RS1001632450 (14:20200385 G>A), RS1001966532 (14:20194189 T>A,C), RS1002172082 (14:20193848 G>A,C), RS1002576600 (14:20198833 A>C), RS1002781386 (14:20199491 G>A), RS1002966606 (14:20192826 G>A), RS1003043497 (14:20198980 T>C), RS1003175391 (14:20195375 T>C), RS1003312505 (14:20195146 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	increases expression	1
maleic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Cadmium	decreases expression, increases abundance	1
Plant Extracts	decreases expression, affects cotreatment	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.