OR11H12

Summary

OR11H12 (olfactory receptor family 11 subfamily H member 12, HGNC:30738) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 11H12 (B2RN74). Odorant receptor. It is a selective cancer dependency (DepMap: 20.0% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 440153 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 99 total
• Cancer dependency (DepMap): dependent in 20.0% of screened cell lines
• MANE Select transcript: NM_001013354

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30738
Approved symbol	OR11H12
Name	olfactory receptor family 11 subfamily H member 12
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000257115
Ensembl biotype	protein_coding
Entrez	440153

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000550708

RefSeq mRNA: 1 — MANE Select: NM_001013354 NM_001013354

CCDS: CCDS32017

Canonical transcript exons

ENST00000550708 — 1 exons

Exon	Start	End
ENSE00004472043	18601117	18602097

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 88.04.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.30	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.53	gold quality
leukocyte	CL:0000738	29.35	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
urinary bladder	UBERON:0001255	27.16	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.95	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
pancreas	UBERON:0001264	25.50	gold quality
ectocervix	UBERON:0012249	25.37	gold quality
endometrium	UBERON:0001295	25.03	gold quality
muscle of leg	UBERON:0001383	24.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 20.0% of screened cell lines.

Cross-species orthologs

0 orthologs

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 11H12 — B2RN74 (reviewed: B2RN74)

All UniProt accessions (1): B2RN74

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001013372* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 3, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-B2RN74-F1	79.30	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 112–194

Glycosylation sites (3): 13, 18, 106

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 13 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr14q11, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

206 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR11H12	PRAMEF10	O60809	577
OR11H12	RAX2	Q96IS3	445
OR11H12	POTEG	Q6S5H5	399
OR11H12	SLC9B1	Q4ZJI4	397
OR11H12	CIMIP2A	Q6J272	378
OR11H12	SETSIP	P0DME0	373
OR11H12	POTEM	A6NI47	370
OR11H12	CRLF1	O75462	366
OR11H12	Q12799	Q12799	354
OR11H12	VSIG10	Q8N0Z9	353
OR11H12	MYO15B	Q96JP2	349
OR11H12	PCDHGA8	Q9Y5G5	348
OR11H12	ZNF232	Q9UNY5	324
OR11H12	LLPH	Q9BRT6	320
OR11H12	WASHC2A	Q641Q2	320

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6ND48, B2RN74, O60412, O76099, O76100, O95047, P23271, P23272, P34982, P37069, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGE0, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGS2, Q8NGW1, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07, Q8NH80, Q8NHA4, Q8NHC7, Q8VEY3, Q8VFC9, Q8WZA6

Diamond homologs: A6NDH6, A6NKK0, A6NL08, B2RN74, O43749, O76002, O95006, O95007, O95221, O95222, P0C626, P0C628, P0C7N5, P0C7N8, P0DN80, P0DN82, P23266, P23267, P23270, P23274, P34984, P34986, P58173, P58181, P58182, Q13606, Q13607, Q5TZ20, Q60889, Q60890, Q60893, Q60894, Q6IFH4, Q7TR96, Q8N0Y5, Q8N127, Q8NG75, Q8NG94, Q8NGC1, Q8NGC5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

99 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	92
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

249 predictions. Top by Δscore:

Variant	Effect	Δscore
14:18601448:G:GT	donor_gain	0.6500
14:18601217:G:GG	donor_gain	0.6400
14:18601902:G:GA	donor_gain	0.5800
14:18601190:A:G	donor_gain	0.5500
14:18601486:ACATC:A	donor_gain	0.5300
14:18601765:C:CG	donor_gain	0.5200
14:18601806:T:A	acceptor_gain	0.5200
14:18601284:G:T	donor_gain	0.5100
14:18601526:A:AG	donor_gain	0.5100
14:18601527:G:GG	donor_gain	0.5100
14:18601214:CTT:C	donor_gain	0.4800
14:18601372:ATATG:A	donor_loss	0.4800
14:18601373:TATGG:T	donor_loss	0.4800
14:18601374:ATGG:A	donor_loss	0.4800
14:18601375:TG:T	donor_loss	0.4800
14:18601376:GG:G	donor_loss	0.4800
14:18601377:G:GA	donor_loss	0.4800
14:18601378:TATGT:T	donor_loss	0.4800
14:18601482:G:A	acceptor_gain	0.4700
14:18601931:TC:T	donor_gain	0.4700
14:18601372:A:G	donor_gain	0.4600
14:18601765:C:G	donor_gain	0.4600
14:18601968:G:T	donor_gain	0.4600
14:18601260:A:AG	acceptor_gain	0.4500
14:18601379:AT:A	donor_loss	0.4500
14:18601394:T:G	acceptor_gain	0.4500
14:18602033:GC:G	acceptor_gain	0.4500
14:18601176:C:G	donor_gain	0.4400
14:18601215:TT:T	donor_gain	0.4400
14:18601377:G:GG	donor_gain	0.4400

AlphaMissense

2141 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:18601195:T:C	F27L	0.809
14:18601197:T:A	F27L	0.809
14:18601197:T:G	F27L	0.809
14:18601210:T:C	F32L	0.767
14:18601212:C:A	F32L	0.767
14:18601212:C:G	F32L	0.767
14:18601663:T:C	F183L	0.745
14:18601665:C:A	F183L	0.745
14:18601665:C:G	F183L	0.745
14:18601243:T:C	F43L	0.693
14:18601245:C:A	F43L	0.693
14:18601245:C:G	F43L	0.693
14:18601618:T:C	F168L	0.673
14:18601620:T:A	F168L	0.673
14:18601620:T:G	F168L	0.673
14:18601441:T:C	F109L	0.625
14:18601443:T:A	F109L	0.625
14:18601443:T:G	F109L	0.625
14:18601462:T:C	F116L	0.618
14:18601464:T:A	F116L	0.618
14:18601464:T:G	F116L	0.618
14:18601873:T:C	F253L	0.614
14:18601875:C:A	F253L	0.614
14:18601875:C:G	F253L	0.614
14:18601627:T:C	F171L	0.607
14:18601629:C:A	F171L	0.607
14:18601629:C:G	F171L	0.607
14:18601252:T:C	F46L	0.585
14:18601254:T:A	F46L	0.585
14:18601254:T:G	F46L	0.585

dbSNP variants (sampled 300 via entrez): RS1001382119 (14:18599441 A>T), RS1004544455 (14:18599160 C>T), RS1016044287 (14:18599172 A>G), RS1020611418 (14:18599832 T>G), RS1029107331 (14:18601974 G>A), RS1034161151 (14:18599624 T>C), RS1039167484 (14:18599141 G>A), RS1041537590 (14:18602358 C>T), RS1041915027 (14:18601635 C>A,T), RS1051870729 (14:18599157 T>A,C), RS1052058907 (14:18601162 G>A,C), RS1055586334 (14:18601355 A>T), RS113475621 (14:18600244 G>A,C,T), RS11486340 (14:18599593 G>C,T), RS1156274569 (14:18599699 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Folic Acid	decreases expression	1
Malathion	increases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.