OR11H6

Summary

OR11H6 (olfactory receptor family 11 subfamily H member 6, HGNC:15349) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 11H6 (Q8NGC7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 122748 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001004480

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15349
Approved symbol	OR11H6
Name	olfactory receptor family 11 subfamily H member 6
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176219
Ensembl biotype	protein_coding
Entrez	122748

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000315519

RefSeq mRNA: 1 — MANE Select: NM_001004480 NM_001004480

CCDS: CCDS32033

Canonical transcript exons

ENST00000315519 — 1 exons

Exon	Start	End
ENSE00001254162	20223710	20224702

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 47.64.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	47.64	silver quality
bone marrow cell	CL:0002092	38.41	gold quality
granulocyte	CL:0000094	37.53	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
right uterine tube	UBERON:0001302	33.43	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	29.32	gold quality
lymph node	UBERON:0000029	28.99	gold quality
tonsil	UBERON:0002372	28.75	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
calcaneal tendon	UBERON:0003701	27.38	gold quality
leukocyte	CL:0000738	27.32	gold quality
endocervix	UBERON:0000458	26.97	gold quality
urinary bladder	UBERON:0001255	26.84	gold quality
monocyte	CL:0000576	26.64	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.49	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
placenta	UBERON:0001987	25.81	gold quality
uterine cervix	UBERON:0000002	25.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or11h6	ENSMUSG00000050028
rattus_norvegicus	Or11h6	ENSRNOG00000008800

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 11H6 — Q8NGC7 (reviewed: Q8NGC7)

Alternative names: Olfactory receptor OR14-35

All UniProt accessions (2): A0A126GVP4, Q8NGC7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004480* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (25 total): topological domain 8, transmembrane region 7, sequence variant 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC7-F1	86.98	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 115–207

Glycosylation sites (1): 21

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MAFG_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

80 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR11H6	RTP1	P59025	283
OR11H6	TAAR5	O14804	252
OR11H6	TAAR2	Q9P1P5	244
OR11H6	TAAR6	Q96RI8	242
OR11H6	ZMAT4	Q9H898	236
OR11H6	MS4A8	Q9BY19	224
OR11H6	RBM47	A0AV96	221
OR11H6	COBL	O75128	218
OR11H6	RAB3C	Q96E17	204
OR11H6	ADRB2	P07550	194
OR11H6	GUCY2D	Q02846	161
OR11H6	CFTR	P13569	158
OR11H6	OR52E4	Q8NGH9	154
OR11H6	PDE2A	O00408	153
OR11H6	OR56B1	Q8NGI3	142

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76000, O95007, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P23267, P23269, P23272, P23273, P23274, P30955, P34984, P34985, P34986, P58173, P70526, Q15620, Q5TZ20, Q60880, Q60882, Q60890, Q60893, Q6UXT6, Q7TQQ0, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGC5, Q8NGC7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

156 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20223754:A:AG	acceptor_gain	0.7400
14:20223755:G:GG	acceptor_gain	0.7400
14:20224519:T:G	acceptor_gain	0.7300
14:20224518:AT:A	acceptor_gain	0.7000
14:20224453:T:TA	acceptor_gain	0.6900
14:20224519:T:TA	acceptor_gain	0.6800
14:20223755:GCTTT:G	acceptor_gain	0.6200
14:20224270:T:TA	acceptor_gain	0.5700
14:20223826:G:GT	donor_gain	0.5500
14:20224518:ATG:A	acceptor_gain	0.5500
14:20223751:AACAG:A	acceptor_loss	0.5400
14:20223752:ACAG:A	acceptor_loss	0.5400
14:20223753:CAGC:C	acceptor_loss	0.5400
14:20223754:AGCTT:A	acceptor_loss	0.5400
14:20223808:G:A	acceptor_gain	0.5200
14:20223755:GCT:G	acceptor_gain	0.5100
14:20224530:T:TA	acceptor_gain	0.5100
14:20223939:T:G	donor_gain	0.5000
14:20224520:G:A	acceptor_gain	0.4800
14:20224529:AT:A	acceptor_gain	0.4800
14:20223751:A:AG	acceptor_gain	0.4700
14:20224177:G:GT	donor_gain	0.4700
14:20224177:G:T	donor_gain	0.4700
14:20224418:ACTCT:A	acceptor_gain	0.4700
14:20224498:AAT:A	acceptor_gain	0.4600
14:20224408:G:A	acceptor_gain	0.4500
14:20223807:T:TA	acceptor_gain	0.4400
14:20223755:GCTT:G	acceptor_gain	0.4300
14:20224271:G:A	acceptor_gain	0.4300
14:20224347:CTG:C	acceptor_gain	0.4300

AlphaMissense

2149 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:20223797:T:C	F30L	0.954
14:20223799:T:A	F30L	0.954
14:20223799:T:G	F30L	0.954
14:20223972:A:T	E88V	0.949
14:20224265:T:C	F186L	0.948
14:20224267:C:A	F186L	0.948
14:20224267:C:G	F186L	0.948
14:20224514:T:C	F269L	0.943
14:20224516:C:A	F269L	0.943
14:20224516:C:G	F269L	0.943
14:20224128:G:C	R140P	0.941
14:20224634:A:C	S309R	0.940
14:20224636:T:A	S309R	0.940
14:20224636:T:G	S309R	0.940
14:20224621:T:A	N304K	0.924
14:20224621:T:G	N304K	0.924
14:20224117:G:A	M136I	0.922
14:20224117:G:C	M136I	0.922
14:20224117:G:T	M136I	0.922
14:20224125:A:C	D139A	0.915
14:20224205:T:C	C166R	0.913
14:20224298:T:A	C197S	0.911
14:20224299:G:C	C197S	0.911
14:20223972:A:C	E88A	0.906
14:20224208:T:A	W167R	0.902
14:20224208:T:C	W167R	0.902
14:20224217:G:A	G170R	0.902
14:20224217:G:C	G170R	0.902
14:20223889:T:A	N60K	0.899
14:20223889:T:G	N60K	0.899

dbSNP variants (sampled 300 via entrez): RS1000770475 (14:20221910 A>G), RS1000956815 (14:20221800 G>A,C,T), RS1001389486 (14:20221902 T>A), RS1001674099 (14:20222849 G>C), RS1002359720 (14:20223111 C>G), RS1007312417 (14:20223826 G>A,C), RS1007900068 (14:20224955 G>A), RS1008221104 (14:20225178 G>A), RS1009694505 (14:20221930 A>C,T), RS1010697124 (14:20223491 C>A,T), RS1011526674 (14:20224788 G>A,T), RS1013768546 (14:20222958 T>C,G), RS10140652 (14:20223729 C>A,T), RS10144893 (14:20222825 T>C,G), RS10148193 (14:20221893 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1909	Metabolite levels	8.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010463	asymmetric dimethylarginine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.