OR11H7

Summary

OR11H7 (olfactory receptor family 11 subfamily H member 7 (gene/pseudogene), HGNC:15350) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 11H7 (Q8NGC8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 390441 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15350
Approved symbol	OR11H7
Name	olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000258806
Ensembl biotype	protein_coding
Entrez	390441

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000553765

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553765 — 1 exons

Exon	Start	End
ENSE00002471111	20229402	20230346

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 86.75.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.75	gold quality
right ovary	UBERON:0002118	54.54	gold quality
ovary	UBERON:0000992	51.89	gold quality
left ovary	UBERON:0002119	51.35	gold quality
right uterine tube	UBERON:0001302	50.98	gold quality
cortical plate	UBERON:0005343	49.42	gold quality
granulocyte	CL:0000094	49.40	silver quality
left testis	UBERON:0004533	48.53	gold quality
body of uterus	UBERON:0009853	47.92	gold quality
testis	UBERON:0000473	47.38	gold quality
left uterine tube	UBERON:0001303	47.27	gold quality
ectocervix	UBERON:0012249	46.97	gold quality
right testis	UBERON:0004534	46.83	gold quality
nucleus accumbens	UBERON:0001882	46.29	gold quality
right coronary artery	UBERON:0001625	46.27	gold quality
primary visual cortex	UBERON:0002436	45.95	silver quality
endometrium	UBERON:0001295	45.90	gold quality
thoracic mammary gland	UBERON:0005200	45.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	44.97	gold quality
fallopian tube	UBERON:0003889	44.62	gold quality
right lung	UBERON:0002167	44.50	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	44.01	gold quality
uterine cervix	UBERON:0000002	43.98	gold quality
tibial artery	UBERON:0007610	43.97	gold quality
popliteal artery	UBERON:0002250	43.84	gold quality
putamen	UBERON:0001874	43.73	gold quality
myometrium	UBERON:0001296	43.16	gold quality
placenta	UBERON:0001987	42.71	gold quality
prostate gland	UBERON:0002367	42.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	41.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• possible functional role of OR11H7P in isovaleric acid detection (PMID:17973576)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or11h7	ENSMUSG00000058188
mus_musculus	Or11h23	ENSMUSG00000060084
rattus_norvegicus	Or11h23b	ENSRNOG00000008804

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 11H7 — Q8NGC8 (reviewed: Q8NGC8)

Alternative names: Olfactory receptor OR14-32

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor. Activated by isovaleric acid.

Subcellular location. Cell membrane.

Polymorphism. A stop codon in the gene coding for this protein at position Gln-227 is responsible for functional diversity thus producing a pseudogene. Hypersensitivity towards isovaleric acid is seen predominantly in individuals who carry at least one copy of the intact allele.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC8-F1	90.73	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SRSF9_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr14q11

GO Biological Process (0):

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (1): plasma membrane (GO:0005886)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76000, O95007, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P23267, P23269, P23272, P23273, P23274, P30955, P34984, P34985, P34986, P58173, P70526, Q15620, Q5TZ20, Q60880, Q60882, Q60890, Q60893, Q6UXT6, Q7TQQ0, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGC5, Q8NGC7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

192 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20230272:A:AG	acceptor_gain	0.8300
14:20230273:G:GG	acceptor_gain	0.8300
14:20229721:T:TA	acceptor_gain	0.8100
14:20229722:G:A	acceptor_gain	0.7000
14:20229555:G:GT	donor_gain	0.6900
14:20229578:G:GG	donor_gain	0.6800
14:20230267:T:G	acceptor_gain	0.6800
14:20230271:C:G	acceptor_gain	0.6800
14:20230157:T:G	acceptor_gain	0.6600
14:20230179:G:GG	donor_gain	0.6500
14:20230266:A:AG	acceptor_gain	0.6500
14:20230273:GC:G	acceptor_gain	0.6500
14:20229577:T:G	donor_gain	0.6400
14:20229612:ATCTG:A	donor_loss	0.6400
14:20229613:TCTGG:T	donor_loss	0.6400
14:20229615:TGG:T	donor_loss	0.6400
14:20229616:GGTA:G	donor_loss	0.6400
14:20229617:G:GA	donor_loss	0.6400
14:20229618:T:TG	donor_loss	0.6400
14:20229619:ATGT:A	donor_loss	0.6400
14:20230273:GCC:G	acceptor_gain	0.6400
14:20229620:TGTG:T	donor_loss	0.6300
14:20229545:A:AG	donor_gain	0.6200
14:20229546:G:GG	donor_gain	0.6200
14:20229554:G:A	donor_gain	0.6200
14:20230269:TACA:T	acceptor_loss	0.6200
14:20230271:CAGCC:C	acceptor_loss	0.6200
14:20230273:GCCT:G	acceptor_gain	0.6200
14:20229552:T:TA	donor_gain	0.6100
14:20230175:GTAT:G	donor_gain	0.6100

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000540875 (14:20226996 G>A,C), RS1001054084 (14:20227154 A>C,G), RS1001971545 (14:20229087 T>C), RS1002974720 (14:20230340 A>T), RS1004383215 (14:20227541 T>C), RS1004838708 (14:20227288 G>A,T), RS1005261513 (14:20227048 C>T), RS1005860843 (14:20228660 A>G), RS1006967505 (14:20229811 C>G,T), RS1007128999 (14:20231200 C>A,T), RS1007722955 (14:20230223 C>G,T), RS1007970019 (14:20230776 T>C), RS1010216594 (14:20227855 A>G), RS1010299511 (14:20230968 C>G), RS1011357124 (14:20229121 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.