OR13C2

Summary

OR13C2 (olfactory receptor family 13 subfamily C member 2, HGNC:14701) is a protein-coding gene on chromosome 9q31.1, encoding Olfactory receptor 13C2 (Q8NGS9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 392376 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_001004481

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14701
Approved symbol	OR13C2
Name	olfactory receptor family 13 subfamily C member 2
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000276119
Ensembl biotype	protein_coding
Entrez	392376

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000542196

RefSeq mRNA: 1 — MANE Select: NM_001004481 NM_001004481

CCDS: CCDS35092

Canonical transcript exons

ENST00000542196 — 1 exons

Exon	Start	End
ENSE00002271723	104604671	104605627

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 55.40.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.40	gold quality
right uterine tube	UBERON:0001302	50.50	gold quality
adenohypophysis	UBERON:0002196	47.42	gold quality
pituitary gland	UBERON:0000007	46.97	gold quality
ventricular zone	UBERON:0003053	41.01	gold quality
cortical plate	UBERON:0005343	40.86	gold quality
adrenal tissue	UBERON:0018303	40.61	silver quality
primary visual cortex	UBERON:0002436	37.91	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
prefrontal cortex	UBERON:0000451	35.69	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
endocervix	UBERON:0000458	34.63	gold quality
superior frontal gyrus	UBERON:0002661	33.52	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.95	gold quality
gall bladder	UBERON:0002110	32.76	gold quality
frontal cortex	UBERON:0001870	32.62	silver quality
left ovary	UBERON:0002119	32.42	silver quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
fallopian tube	UBERON:0003889	31.86	silver quality
ovary	UBERON:0000992	31.68	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	31.32	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
liver	UBERON:0002107	30.52	gold quality
endometrium	UBERON:0001295	30.43	gold quality
cerebral cortex	UBERON:0000956	30.36	silver quality
corpus callosum	UBERON:0002336	30.36	gold quality
caudate nucleus	UBERON:0001873	30.14	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Or13c9	ENSRNOG00000080507

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 13C2 — Q8NGS9 (reviewed: Q8NGS9)

Alternative names: Olfactory receptor OR9-12

All UniProt accessions (2): Q8NGS9, A0A126GWR7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004481* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGS9-F1	83.36	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, LHX2_TARGET_GENES, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (3): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cellular anatomical structure	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
nuclear lumen	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

62 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13C2	NIPSNAP3A	Q9UFN0	582
OR13C2	VWDE	Q8N2E2	348
OR13C2	GALNTL6	Q49A17	271
OR13C2	SMARCA4	P51532	264
OR13C2	HNRNPCL1	O60812	247
OR13C2	DGCR2	P98153	246
OR13C2	WRN	Q14191	227
OR13C2	AFG1L	Q8WV93	221
OR13C2	NIPA1	Q7RTP0	183
OR13C2	ZNF804A	Q7Z570	182
OR13C2	SNX3	O60493	167
OR13C2	ABCA1	O95477	164
OR13C2	CNTN6	Q9UQ52	163
OR13C2	GATA1	P15976	161
OR13C2	MUC6	Q6W4X9	156

IntAct

0 interactions, top by confidence:

BioGRID (2): OR13C2 (Co-fractionation), OR13C2 (Co-fractionation)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A3KFT3, A4D2G3, O43749, O60412, O76000, O76001, O76002, O95006, O95047, O95371, O95918, P0C626, P23266, P23269, P23272, P23273, P23274, P23275, P30953, P30955, P34982, P34984, P34986, P58173, P58181, P59922, P70526, Q13606, Q13607, Q15617, Q15619, Q5TZ20, Q60879, Q60890, Q6IEU7, Q6IF42, Q6UXT6, Q8N628, Q8NGA1, Q8NGC9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

272 predictions. Top by Δscore:

Variant	Effect	Δscore
9:104605217:A:AC	donor_gain	0.7000
9:104605218:C:CC	donor_gain	0.7000
9:104604773:CCCA:C	acceptor_gain	0.6200
9:104605559:AAGT:A	donor_gain	0.6200
9:104605439:C:T	acceptor_gain	0.6100
9:104605560:A:C	donor_gain	0.6100
9:104604871:CA:C	acceptor_gain	0.6000
9:104605559:A:AC	donor_gain	0.6000
9:104604738:C:CC	acceptor_gain	0.5900
9:104605439:C:CT	acceptor_gain	0.5900
9:104604847:T:TA	donor_gain	0.5800
9:104605212:T:TA	donor_gain	0.5700
9:104605555:A:C	donor_gain	0.5700
9:104604775:CA:C	acceptor_gain	0.5600
9:104604972:G:C	acceptor_gain	0.5600
9:104604872:A:C	acceptor_gain	0.5400
9:104604971:C:CT	acceptor_gain	0.5400
9:104605581:C:CA	donor_gain	0.5400
9:104604737:ACTGT:A	acceptor_gain	0.5300
9:104604972:G:GC	acceptor_gain	0.5300
9:104605440:A:T	acceptor_gain	0.5300
9:104604886:C:CT	donor_gain	0.5200
9:104605218:CT:C	donor_gain	0.5200
9:104604967:T:TC	acceptor_gain	0.5100
9:104605556:C:CC	donor_gain	0.5100
9:104604882:A:AC	donor_gain	0.5000
9:104605596:TCC:T	donor_gain	0.5000
9:104604737:A:AC	acceptor_gain	0.4900
9:104604816:T:TA	donor_gain	0.4900
9:104605381:CTAG:C	donor_gain	0.4900

AlphaMissense

2116 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:104605592:A:C	F12L	0.942
9:104605592:A:T	F12L	0.942
9:104605594:A:G	F12L	0.942
9:104605414:A:G	C72R	0.917
9:104605089:T:A	E180V	0.911
9:104605124:G:C	F168L	0.896
9:104605124:G:T	F168L	0.896
9:104605126:A:G	F168L	0.896
9:104604737:A:C	S297R	0.895
9:104604737:A:T	S297R	0.895
9:104604739:T:G	S297R	0.895
9:104604875:G:C	F251L	0.880
9:104604875:G:T	F251L	0.880
9:104604877:A:G	F251L	0.880
9:104605338:C:G	C97S	0.872
9:104605339:A:T	C97S	0.872
9:104605263:C:G	R122P	0.864
9:104605339:A:G	C97R	0.859
9:104604731:T:A	R299S	0.852
9:104604731:T:G	R299S	0.852
9:104605093:A:G	C179R	0.849
9:104605097:G:C	F177L	0.845
9:104605097:G:T	F177L	0.845
9:104605099:A:G	F177L	0.845
9:104605077:A:T	V184D	0.844
9:104604920:T:A	K236N	0.836
9:104604920:T:G	K236N	0.836
9:104605089:T:G	E180A	0.835
9:104605322:G:C	F102L	0.833
9:104605322:G:T	F102L	0.833

dbSNP variants (sampled 300 via entrez): RS1000065931 (9:104605687 G>A,T), RS1000077260 (9:104606037 T>G), RS1001033040 (9:104607265 T>A,C), RS1001086695 (9:104607466 G>A,C), RS1006606925 (9:104606148 T>C), RS1006658428 (9:104606324 C>A,T), RS1007612077 (9:104607514 G>A), RS10114059 (9:104606272 A>T), RS10114993 (9:104607611 A>T), RS1011725624 (9:104604367 C>A,G,T), RS10117926 (9:104606136 A>C,G), RS1012801841 (9:104605253 A>T), RS1014193396 (9:104607221 GA>G), RS10156474 (9:104604727 T>A,C,G), RS1016671809 (9:104606325 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.