OR13C5

Summary

OR13C5 (olfactory receptor family 13 subfamily C member 5, HGNC:15100) is a protein-coding gene on chromosome 9q31.1, encoding Olfactory receptor 13C5 (Q8NGS8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 138799 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_001004482

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15100
Approved symbol	OR13C5
Name	olfactory receptor family 13 subfamily C member 5
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000277556
Ensembl biotype	protein_coding
Entrez	138799

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000374779

RefSeq mRNA: 1 — MANE Select: NM_001004482 NM_001004482

CCDS: CCDS35091

Canonical transcript exons

ENST00000374779 — 1 exons

Exon	Start	End
ENSE00002220636	104598457	104599413

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 89.15.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.15	silver quality
ventricular zone	UBERON:0003053	44.16	silver quality
primary visual cortex	UBERON:0002436	42.56	silver quality
pituitary gland	UBERON:0000007	41.10	gold quality
adrenal tissue	UBERON:0018303	38.90	silver quality
adenohypophysis	UBERON:0002196	37.93	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
prefrontal cortex	UBERON:0000451	35.97	gold quality
skeletal muscle tissue	UBERON:0001134	35.58	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
right uterine tube	UBERON:0001302	35.06	gold quality
frontal cortex	UBERON:0001870	32.99	gold quality
bone marrow	UBERON:0002371	32.89	gold quality
muscle tissue	UBERON:0002385	32.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	31.58	silver quality
sural nerve	UBERON:0015488	30.93	gold quality
cerebral cortex	UBERON:0000956	30.90	gold quality
hypothalamus	UBERON:0001898	30.85	silver quality
tonsil	UBERON:0002372	30.56	gold quality
brain	UBERON:0000955	29.92	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
fallopian tube	UBERON:0003889	29.43	silver quality
right adrenal gland cortex	UBERON:0035827	29.24	gold quality
endometrium	UBERON:0001295	28.72	gold quality
caudate nucleus	UBERON:0001873	28.64	silver quality
adrenal gland	UBERON:0002369	28.42	silver quality
gall bladder	UBERON:0002110	28.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Or13c9	ENSRNOG00000080507

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 13C5 — Q8NGS8 (reviewed: Q8NGS8)

Alternative names: Olfactory receptor OR9-11

All UniProt accessions (1): Q8NGS8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004482* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (28 total): sequence variant 10, topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGS8-F1	77.04	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr9q31

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (3): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cellular anatomical structure	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
nuclear lumen	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13C5	C2CD4B	A6NLJ0	507
OR13C5	C11orf91	Q3C1V1	507
OR13C5	GIMAP7	Q8NHV1	506
OR13C5	FCHO2	Q0JRZ9	505
OR13C5	TMEM171	Q8WVE6	505
OR13C5	MUC6	Q6W4X9	478
OR13C5	KCTD6	Q8NC69	471
OR13C5	NIPSNAP3A	Q9UFN0	470
OR13C5	SYNGR1	O43759	448
OR13C5	MUC22	E2RYF6	416
OR13C5	TAS2R19	P59542	396
OR13C5	RAB5C	P51148	393
OR13C5	PXK	Q7Z7A4	374
OR13C5	GIMAP4	Q9NUV9	372
OR13C5	PDHB	P11177	368

IntAct

3 interactions, top by confidence:

A	B	Type	Score
OR13C5	MRPL12	psi-mi:“MI:0915”(physical association)	0.400
OR13C5	SPTB	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): OR13C5 (Proximity Label-MS), SPTB (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, Q60881, Q62007, Q6IF82, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGE8, Q8NGF8, Q8NGF9, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGN8, Q8NGS8, Q8NGT0, Q8NH21, Q8NH42, Q8NH43, Q8NH49, Q8NH70, Q8NH72, Q8NH83, Q8NH85

Diamond homologs: O02664, O13227, O14718, O15973, O16005, O35214, O57422, O60431, O77408, O88634, P02699, P02700, P09241, P14416, P21918, P22328, P24603, P28682, P31356, P32309, P32310, P35403, P41590, P41591, P41983, P49912, P51472, P52702, P60026, P61168, P61169, P79756, P79798, P79807, P79809, P79812, P79863, P79902, P79914, Q17094

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	42
Likely benign	20
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

215 predictions. Top by Δscore:

Variant	Effect	Δscore
9:104598829:ATTG:A	donor_gain	0.7700
9:104599003:A:AC	donor_gain	0.7600
9:104599004:C:CC	donor_gain	0.7600
9:104598668:A:AC	donor_gain	0.7300
9:104598672:C:CT	donor_gain	0.7300
9:104599345:A:AC	donor_gain	0.7200
9:104599345:AAGT:A	donor_gain	0.7200
9:104599346:A:C	donor_gain	0.7100
9:104598641:A:C	donor_gain	0.6700
9:104598832:G:A	donor_gain	0.6600
9:104598558:CC:C	acceptor_gain	0.6500
9:104598559:CC:C	acceptor_gain	0.6500
9:104599341:A:C	donor_gain	0.6500
9:104598633:T:TA	donor_gain	0.6200
9:104598998:T:TA	donor_gain	0.5900
9:104598459:A:AC	donor_gain	0.5800
9:104598460:C:CC	donor_gain	0.5800
9:104598758:G:C	acceptor_gain	0.5800
9:104598941:A:AC	donor_gain	0.5800
9:104598942:C:CC	donor_gain	0.5800
9:104599004:CT:C	donor_gain	0.5700
9:104599367:C:A	donor_gain	0.5700
9:104598556:CACC:C	acceptor_gain	0.5600
9:104598560:C:CC	acceptor_gain	0.5600
9:104598561:T:G	acceptor_loss	0.5400
9:104598562:G:GC	acceptor_gain	0.5400
9:104598999:C:A	donor_gain	0.5400
9:104598636:T:C	donor_gain	0.5300
9:104598758:G:GC	acceptor_gain	0.5300
9:104599167:CTAG:C	donor_gain	0.5300

AlphaMissense

2103 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:104599378:A:C	F12L	0.776
9:104599378:A:T	F12L	0.776
9:104599380:A:G	F12L	0.776
9:104598910:G:C	F168L	0.750
9:104598910:G:T	F168L	0.750
9:104598912:A:G	F168L	0.750
9:104599108:G:C	F102L	0.695
9:104599108:G:T	F102L	0.695
9:104599110:A:G	F102L	0.695
9:104598661:G:C	F251L	0.674
9:104598661:G:T	F251L	0.674
9:104598663:A:G	F251L	0.674
9:104599231:G:C	F61L	0.651
9:104599231:G:T	F61L	0.651
9:104599233:A:G	F61L	0.651
9:104598883:G:C	F177L	0.647
9:104598883:G:T	F177L	0.647
9:104598885:A:G	F177L	0.647
9:104599330:A:C	F28L	0.614
9:104599330:A:T	F28L	0.614
9:104599332:A:G	F28L	0.614
9:104599228:A:C	F62L	0.613
9:104599228:A:T	F62L	0.613
9:104599230:A:G	F62L	0.613
9:104599054:A:C	F120L	0.607
9:104599054:A:T	F120L	0.607
9:104599056:A:G	F120L	0.607

dbSNP variants (sampled 300 via entrez): RS1000055549 (9:104599725 G>A), RS1000626542 (9:104601166 T>C), RS1001017056 (9:104600890 T>C), RS1001066354 (9:104600367 G>A), RS1004201967 (9:104598354 C>T), RS1007222288 (9:104600053 A>G,T), RS1008216321 (9:104601298 TC>T), RS1009668507 (9:104601215 T>A,G), RS1009782693 (9:104600968 A>G), RS1012336343 (9:104599283 G>A), RS1012632085 (9:104599538 G>A), RS1013221538 (9:104600856 T>C,G), RS1013341775 (9:104600346 T>C), RS1015288121 (9:104598355 G>A,C,T), RS1015627931 (9:104598791 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007446_53	vWF levels	2.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.