OR13C7

Summary

OR13C7 (olfactory receptor family 13 subfamily C member 7 (gene/pseudogene), HGNC:15102) is a protein-coding gene on chromosome 9p13.3, encoding Olfactory receptor 13C7 (P0DN81). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 81377 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15102
Approved symbol	OR13C7
Name	olfactory receptor family 13 subfamily C member 7 (gene/pseudogene)
Location	9p13.3
Locus type	gene with protein product
Status	Approved
Aliases	OST706
Ensembl gene	ENSG00000243641
Ensembl biotype	protein_coding
Entrez	81377

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000424348

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424348 — 1 exons

Exon	Start	End
ENSE00001765543	36002909	36003867

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 39.70.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	39.70	silver quality
bone marrow cell	CL:0002092	38.45	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.76	gold quality
mucosa of stomach	UBERON:0001199	34.06	gold quality
bone marrow	UBERON:0002371	32.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	32.07	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.21	gold quality
tonsil	UBERON:0002372	28.79	gold quality
liver	UBERON:0002107	28.27	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	27.80	silver quality
leukocyte	CL:0000738	27.78	silver quality
lymph node	UBERON:0000029	27.57	gold quality
calcaneal tendon	UBERON:0003701	27.10	gold quality
urinary bladder	UBERON:0001255	26.74	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
blood	UBERON:0000178	25.89	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
myometrium	UBERON:0001296	25.21	gold quality
right lung	UBERON:0002167	25.21	gold quality
pancreas	UBERON:0001264	24.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or13c7c	ENSMUSG00000111611
rattus_norvegicus	Or13c7c	ENSRNOG00000070597

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 13C7 — P0DN81 (reviewed: P0DN81)

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Polymorphism. Segregating pseudogene, locus showing both intact and pseudogene forms in the population. A double nucleotide deletion at position Pro-144 in the gene coding for this protein is responsible for functional diversity, producing a pseudogene.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (16 total): topological domain 8, transmembrane region 7, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DN81-F1	86.64	0.55

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, chr9p13, MARTIN_VIRAL_GPCR_SIGNALING_DN, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MIKKELSEN_MCV6_LCP_WITH_H3K27ME3, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (1): detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): nucleoplasm (GO:0005654), plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
nuclear lumen	1
cellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NL08, O76000, O95221, P0C626, P0C629, P0C7N1, P0C7N5, P0DMU2, P0DN81, P30955, P58173, P58181, P59922, P70526, Q15617, Q15620, Q60882, Q60890, Q60893, Q60895, Q6IEU7, Q8NG81, Q8NGF4, Q8NGG4, Q8NGG6, Q8NGH3, Q8NGI9, Q8NGP6, Q8NGP8, Q8NGP9, Q8NGR5, Q8NGS4, Q8NGT0, Q8NGT1, Q8NGZ4, Q8NGZ9, Q8NH01, Q8NH04, Q8NH69, Q8VF76

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

215 predictions. Top by Δscore:

Variant	Effect	Δscore
9:36003307:TCAGG:T	donor_gain	0.6300
9:36003008:CCCA:C	acceptor_gain	0.6200
9:36003209:A:C	acceptor_gain	0.6200
9:36003164:C:CA	donor_gain	0.6000
9:36003160:T:TA	donor_gain	0.5700
9:36003192:G:C	acceptor_gain	0.5600
9:36003192:G:GC	acceptor_gain	0.5500
9:36003009:CCA:C	acceptor_gain	0.5300
9:36003083:C:A	donor_gain	0.5300
9:36003209:A:AC	acceptor_gain	0.5300
9:36003010:CA:C	acceptor_gain	0.5200
9:36003106:C:CT	acceptor_gain	0.5200
9:36003184:T:TG	acceptor_gain	0.5200
9:36003274:T:C	donor_gain	0.5100
9:36003254:A:C	donor_gain	0.5000
9:36003263:TCCCA:T	donor_gain	0.5000
9:36003011:A:C	acceptor_gain	0.4900
9:36003114:A:AC	donor_gain	0.4900
9:36003165:C:A	donor_gain	0.4900
9:36003201:A:C	acceptor_gain	0.4900
9:36003270:CTGA:C	donor_gain	0.4900
9:36003271:TGAT:T	donor_gain	0.4900
9:36003307:T:TA	donor_gain	0.4900
9:36003318:AGAAT:A	donor_gain	0.4900
9:36003171:G:C	donor_gain	0.4800
9:36003189:A:AC	acceptor_gain	0.4800
9:36003196:CAA:C	acceptor_gain	0.4800
9:36003197:A:T	acceptor_gain	0.4800
9:36003208:C:CT	acceptor_gain	0.4800
9:36003269:A:AC	donor_gain	0.4800

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.