OR13C8

Summary

OR13C8 (olfactory receptor family 13 subfamily C member 8, HGNC:15103) is a protein-coding gene on chromosome 9q31.1, encoding Olfactory receptor 13C8 (Q8NGS7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 138802 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001004483

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15103
Approved symbol	OR13C8
Name	olfactory receptor family 13 subfamily C member 8
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186943
Ensembl biotype	protein_coding
Entrez	138802

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000335040

RefSeq mRNA: 1 — MANE Select: NM_001004483 NM_001004483

CCDS: CCDS35090

Canonical transcript exons

ENST00000335040 — 1 exons

Exon	Start	End
ENSE00001340512	104569168	104570130

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 42.25.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	42.25	gold quality
granulocyte	CL:0000094	37.80	gold quality
mucosa of transverse colon	UBERON:0004991	36.50	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.01	gold quality
muscle tissue	UBERON:0002385	32.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
liver	UBERON:0002107	30.51	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.33	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.89	gold quality
monocyte	CL:0000576	26.65	gold quality
blood	UBERON:0000178	26.62	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
cortex of kidney	UBERON:0001225	25.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
adrenal tissue	UBERON:0018303	25.56	gold quality
right adrenal gland cortex	UBERON:0035827	25.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or13c25	ENSMUSG00000051593
rattus_norvegicus	Or13c25	ENSRNOG00000052071

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 13C8 — Q8NGS7 (reviewed: Q8NGS7)

All UniProt accessions (2): Q8NGS7, A0A126GVC7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004483* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGS7-F1	83.66	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (3): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cellular anatomical structure	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
nuclear lumen	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

190 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13C8	TMEM191B	P0C7N4	544
OR13C8	LRRC14B	A6NHZ5	517
OR13C8	FAM47B	Q8NA70	507
OR13C8	ZNF790	Q6PG37	507
OR13C8	TMEM236	Q5W0B7	504
OR13C8	KIAA1143	Q96AT1	480
OR13C8	DZIP1L	Q8IYY4	480
OR13C8	TTC9	Q92623	473
OR13C8	GAL3ST1	Q99999	446
OR13C8	EPB41L4B	Q9H329	434
OR13C8	NIPSNAP3A	Q9UFN0	414
OR13C8	POM121L12	Q8N7R1	405
OR13C8	TAS2R7	Q9NYW3	398
OR13C8	SLC10A7	Q0GE19	382
OR13C8	TRIOBP	Q9H2D6	380

IntAct

0 interactions, top by confidence:

BioGRID (2): OR13C8 (Affinity Capture-MS), OR13C8 (Positive Genetic)

ESM2 similar proteins: O76000, P0C7N1, P0DN81, P30955, P34986, P37071, P58181, Q15620, Q60882, Q60890, Q60893, Q6IEU7, Q8NGA1, Q8NGG1, Q8NGI9, Q8NGL2, Q8NGP2, Q8NGP6, Q8NGP8, Q8NGQ6, Q8NGR5, Q8NGS4, Q8NGS7, Q8NGS9, Q8NGT0, Q8NGZ9, Q8NH01, Q8NH04, Q8VEW5, Q8VEZ0, Q8VF65, Q8VF66, Q8VF76, Q8VFM9, Q8VG02, Q8VG05, Q8VG06, Q8VG08, Q8VG09, Q8VG42

Diamond homologs: A3KFT3, A4D2G3, O43749, O60412, O76000, O76001, O76002, O95006, O95047, O95371, O95918, P0C626, P23266, P23269, P23272, P23273, P23274, P23275, P30953, P30955, P34982, P34984, P34986, P58173, P58181, P59922, P70526, Q13606, Q13607, Q15617, Q15619, Q5TZ20, Q60879, Q60890, Q6IEU7, Q6IF42, Q6UXT6, Q8N628, Q8NGA1, Q8NGC9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

219 predictions. Top by Δscore:

Variant	Effect	Δscore
9:104569823:T:G	acceptor_gain	0.8300
9:104569833:T:A	acceptor_gain	0.8000
9:104569837:A:AG	acceptor_gain	0.7700
9:104569844:T:TA	acceptor_gain	0.7600
9:104569828:A:AG	acceptor_gain	0.7400
9:104569830:T:A	acceptor_gain	0.7300
9:104569294:G:GT	donor_gain	0.6800
9:104569838:C:G	acceptor_gain	0.6700
9:104569840:A:AG	acceptor_gain	0.6700
9:104569822:A:AG	acceptor_gain	0.6600
9:104569310:T:G	donor_gain	0.6400
9:104569824:A:AG	acceptor_gain	0.6400
9:104569829:T:G	acceptor_gain	0.6400
9:104569840:ATTCT:A	acceptor_gain	0.6400
9:104569841:TTCTG:T	acceptor_gain	0.6300
9:104569803:A:AG	acceptor_gain	0.6200
9:104569804:G:GG	acceptor_gain	0.6200
9:104569841:T:G	acceptor_gain	0.6200
9:104569205:TCCTG:T	donor_loss	0.6100
9:104569206:CCTG:C	donor_loss	0.6100
9:104569208:TGGTA:T	donor_loss	0.6100
9:104569209:GGTA:G	donor_loss	0.6100
9:104569210:G:T	donor_loss	0.6100
9:104569211:T:G	donor_loss	0.6100
9:104569828:ATT:A	acceptor_gain	0.6100
9:104569210:G:GG	donor_gain	0.6000
9:104569821:C:G	acceptor_gain	0.5900
9:104570056:A:AG	acceptor_gain	0.5900
9:104570057:G:GG	acceptor_gain	0.5900
9:104569844:TG:T	acceptor_gain	0.5800

AlphaMissense

2104 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:104569390:A:C	S75R	0.947
9:104569392:T:A	S75R	0.947
9:104569392:T:G	S75R	0.947
9:104570056:A:C	S297R	0.914
9:104570058:T:A	S297R	0.914
9:104570058:T:G	S297R	0.914
9:104569918:T:C	F251L	0.901
9:104569920:C:A	F251L	0.901
9:104569920:C:G	F251L	0.901
9:104569201:T:C	F12L	0.888
9:104569203:T:A	F12L	0.888
9:104569203:T:G	F12L	0.888
9:104569532:G:C	R122P	0.884
9:104569875:G:C	K236N	0.870
9:104569875:G:T	K236N	0.870
9:104569669:T:C	F168L	0.868
9:104569671:C:A	F168L	0.868
9:104569671:C:G	F168L	0.868
9:104569879:T:C	F238L	0.866
9:104569881:C:A	F238L	0.866
9:104569881:C:G	F238L	0.866
9:104570063:G:C	R299P	0.855
9:104569612:T:A	W149R	0.852
9:104569612:T:C	W149R	0.852
9:104569696:T:C	F177L	0.842
9:104569698:T:A	F177L	0.842
9:104569698:T:G	F177L	0.842
9:104569521:G:A	M118I	0.839
9:104569521:G:C	M118I	0.839
9:104569521:G:T	M118I	0.839

dbSNP variants (sampled 300 via entrez): RS1001141306 (9:104567306 A>C,G), RS1002317057 (9:104568236 T>C), RS1002915437 (9:104569284 G>A,C), RS1004886740 (9:104567294 C>T), RS1005042695 (9:104569486 A>G,T), RS1007662395 (9:104567802 G>A,T), RS1008510592 (9:104568375 A>G), RS1008563157 (9:104568623 G>A), RS1011620652 (9:104569871 A>G), RS1012096893 (9:104569640 T>C), RS1013426865 (9:104567364 C>A,G,T), RS1013896090 (9:104567730 T>C), RS1014510274 (9:104568376 T>A), RS1014896435 (9:104569012 C>T), RS1015128448 (9:104568194 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.