OR13F1

Summary

OR13F1 (olfactory receptor family 13 subfamily F member 1, HGNC:14723) is a protein-coding gene on chromosome 9q31.1, encoding Olfactory receptor 13F1 (Q8NGS4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 138805 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_001004485

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14723
Approved symbol	OR13F1
Name	olfactory receptor family 13 subfamily F member 1
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186881
Ensembl biotype	protein_coding
Entrez	138805

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000334726

RefSeq mRNA: 1 — MANE Select: NM_001004485 NM_001004485

CCDS: CCDS35087

Canonical transcript exons

ENST00000334726 — 1 exons

Exon	Start	End
ENSE00001340278	104504263	104505222

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 39.44.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	39.44	gold quality
bone marrow cell	CL:0002092	38.57	gold quality
granulocyte	CL:0000094	37.79	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.02	gold quality
adrenal tissue	UBERON:0018303	35.01	gold quality
bone marrow	UBERON:0002371	32.98	gold quality
muscle tissue	UBERON:0002385	32.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
liver	UBERON:0002107	31.59	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.53	gold quality
prefrontal cortex	UBERON:0000451	29.42	gold quality
monocyte	CL:0000576	29.06	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	28.01	gold quality
corpus callosum	UBERON:0002336	27.78	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.40	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
right lobe of liver	UBERON:0001114	26.27	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	adra1ab	ENSDARG00000027638
danio_rerio	adra2db	ENSDARG00000054667
danio_rerio	adra2da	ENSDARG00000091277
mus_musculus	Or13f5	ENSMUSG00000089717
rattus_norvegicus	Or13f5	ENSRNOG00000085192
rattus_norvegicus	Or13f5l1	ENSRNOG00000090684
caenorhabditis_elegans	ser-5	WBGENE00008890

Paralogs (18): ADRB1 (ENSG00000043591), ADRA1A (ENSG00000120907), DRD2 (ENSG00000149295), ADRA2A (ENSG00000150594), GPR101 (ENSG00000165370), ADRB2 (ENSG00000169252), ADRA1B (ENSG00000170214), ADRA1D (ENSG00000171873), OR5T3 (ENSG00000172489), OR56A1 (ENSG00000180934), OR5T1 (ENSG00000181698), OR5T2 (ENSG00000181718), OR56A4 (ENSG00000183389), ADRA2C (ENSG00000184160), OR56A3 (ENSG00000184478), OR56A5 (ENSG00000188691), ADRB3 (ENSG00000188778), ADRA2B (ENSG00000274286)

Protein

Protein identifiers

Olfactory receptor 13F1 — Q8NGS4 (reviewed: Q8NGS4)

Alternative names: Olfactory receptor OR9-6

All UniProt accessions (1): Q8NGS4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004485* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 6, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGS4-F1	86.87	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

218 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13F1	TAS2R60	P59551	439
OR13F1	TMEM248	Q9NWD8	431
OR13F1	GAL3ST3	Q96A11	419
OR13F1	PLEKHG4B	Q96PX9	418
OR13F1	SYT14	Q8NB59	376
OR13F1	SPATA17	Q96L03	372
OR13F1	ATP1B4	Q9UN42	366
OR13F1	ATP13A5	Q4VNC0	363
OR13F1	VWC2	Q2TAL6	359
OR13F1	NAA30	Q147X3	350
OR13F1	STX10	O60499	324
OR13F1	NXNL1	Q96CM4	320
OR13F1	CSHL1	Q14406	314
OR13F1	RABL6	Q3YEC7	309
OR13F1	INHBC	P55103	300

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

295 predictions. Top by Δscore:

Variant	Effect	Δscore
9:104504932:A:AG	acceptor_gain	0.8200
9:104504933:G:GG	acceptor_gain	0.8200
9:104504851:T:G	donor_gain	0.7700
9:104504525:G:GT	donor_gain	0.7600
9:104504933:GTAT:G	acceptor_gain	0.7400
9:104504847:GC:G	donor_gain	0.7200
9:104504865:GATC:G	donor_gain	0.7000
9:104504866:ATCA:A	donor_gain	0.7000
9:104504933:GT:G	acceptor_gain	0.7000
9:104504287:G:GG	donor_gain	0.6800
9:104504933:GTATC:G	acceptor_gain	0.6700
9:104504928:C:A	acceptor_gain	0.6600
9:104504768:GTG:G	donor_gain	0.6400
9:104504293:G:GG	donor_gain	0.6300
9:104504933:GTA:G	acceptor_gain	0.6300
9:104504916:T:G	acceptor_gain	0.6200
9:104504435:C:CG	donor_gain	0.6100
9:104504867:T:G	donor_gain	0.6100
9:104505002:TGG:T	donor_gain	0.6100
9:104504820:ATT:A	donor_gain	0.6000
9:104504919:A:AG	acceptor_gain	0.6000
9:104504924:T:G	acceptor_gain	0.6000
9:104505003:G:GG	donor_gain	0.6000
9:104505004:G:GG	donor_gain	0.6000
9:104504915:A:AG	acceptor_gain	0.5900
9:104504932:A:AC	acceptor_loss	0.5900
9:104504933:G:GA	acceptor_loss	0.5900
9:104504736:G:GA	donor_gain	0.5800
9:104504916:T:TA	acceptor_gain	0.5800
9:104504923:A:AG	acceptor_gain	0.5800

AlphaMissense

2095 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:104504791:T:C	F177L	0.777
9:104504793:C:A	F177L	0.777
9:104504793:C:G	F177L	0.777
9:104504974:T:C	F238L	0.736
9:104504976:T:A	F238L	0.736
9:104504976:T:G	F238L	0.736
9:104505013:T:C	F251L	0.734
9:104505015:C:A	F251L	0.734
9:104505015:C:G	F251L	0.734
9:104504296:T:C	F12L	0.711
9:104504298:T:A	F12L	0.711
9:104504298:T:G	F12L	0.711
9:104504446:T:C	F62L	0.696
9:104504448:C:A	F62L	0.696
9:104504448:C:G	F62L	0.696
9:104504970:A:C	K236N	0.676
9:104504970:A:T	K236N	0.676
9:104504344:T:C	F28L	0.670
9:104504346:T:A	F28L	0.670
9:104504346:T:G	F28L	0.670
9:104504542:T:C	F94L	0.635
9:104504544:C:A	F94L	0.635
9:104504544:C:G	F94L	0.635
9:104505133:A:C	S291R	0.632
9:104505135:T:A	S291R	0.632
9:104505135:T:G	S291R	0.632
9:104504616:G:A	M118I	0.600
9:104504616:G:C	M118I	0.600
9:104504616:G:T	M118I	0.600
9:104504920:T:C	F220L	0.586

dbSNP variants (sampled 300 via entrez): RS1000316282 (9:104502418 G>C), RS1001203763 (9:104503898 G>A,C), RS1004341811 (9:104502757 G>T), RS1004628845 (9:104504509 G>A,T), RS1007756351 (9:104505718 A>G), RS1008018042 (9:104503975 A>T), RS1008090222 (9:104504225 C>A,T), RS1008520141 (9:104503980 G>A,C), RS1010547467 (9:104505288 C>A,G), RS1010795661 (9:104503935 A>C,G), RS1011437681 (9:104503739 T>C,G), RS1011444010 (9:104505483 A>G), RS1011561348 (9:104504963 G>A,T), RS1012065671 (9:104504801 A>C), RS1013929903 (9:104503316 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.