OR13G1

Summary

OR13G1 (olfactory receptor family 13 subfamily G member 1, HGNC:14999) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 13G1 (Q8NGZ3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 441933 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_001005487

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14999
Approved symbol	OR13G1
Name	olfactory receptor family 13 subfamily G member 1
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197437
Ensembl biotype	protein_coding
OMIM	611677
Entrez	441933

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000642119

RefSeq mRNA: 1 — MANE Select: NM_001005487 NM_001005487

CCDS: CCDS31094

Canonical transcript exons

ENST00000642119 — 2 exons

Exon	Start	End
ENSE00003813766	247679640	247679739
ENSE00003814159	247670812	247673279

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 46.28.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	46.28	gold quality
sural nerve	UBERON:0015488	42.79	gold quality
bone marrow cell	CL:0002092	38.66	gold quality
granulocyte	CL:0000094	37.49	gold quality
calcaneal tendon	UBERON:0003701	36.60	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
adrenal tissue	UBERON:0018303	36.18	gold quality
tonsil	UBERON:0002372	35.93	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.47	gold quality
skeletal muscle tissue	UBERON:0001134	34.94	gold quality
bone marrow	UBERON:0002371	33.02	gold quality
leukocyte	CL:0000738	32.24	gold quality
muscle tissue	UBERON:0002385	32.21	gold quality
monocyte	CL:0000576	32.05	gold quality
right testis	UBERON:0004534	29.89	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
endometrium	UBERON:0001295	29.83	gold quality
myometrium	UBERON:0001296	29.78	gold quality
liver	UBERON:0002107	29.40	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
testis	UBERON:0000473	29.20	silver quality
left testis	UBERON:0004533	28.97	silver quality
uterine cervix	UBERON:0000002	28.55	gold quality
transverse colon	UBERON:0001157	28.50	gold quality
duodenum	UBERON:0002114	28.14	gold quality
ectocervix	UBERON:0012249	28.04	gold quality
primary visual cortex	UBERON:0002436	27.75	gold quality
prostate gland	UBERON:0002367	27.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or13g1	ENSMUSG00000054054
rattus_norvegicus	Or13g1	ENSRNOG00000078562

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 13G1 — Q8NGZ3 (reviewed: Q8NGZ3)

Alternative names: Olfactory receptor OR1-37

All UniProt accessions (1): Q8NGZ3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005487* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGZ3-F1	86.35	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 94–186

Glycosylation sites (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

210 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13G1	TAS2R50	P59544	979
OR13G1	PALLD	Q8WX93	930
OR13G1	ROS1	P08922	915
OR13G1	ZNF627	Q7L945	620
OR13G1	KRTAP5-11	Q6L8G4	607
OR13G1	KRTAP5-10	Q6L8G5	537
OR13G1	KRTAP5-7	Q6L8G8	479
OR13G1	TAS2R41	P59536	448
OR13G1	CASP5	P51878	438
OR13G1	TAS2R10	Q9NYW0	428
OR13G1	KRTAP5-5	Q701N2	412
OR13G1	MYPN	Q86TC9	385
OR13G1	MYOT	Q9UBF9	384
OR13G1	MRC1	P22897	374
OR13G1	CASP1	P29466	368

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR13G1	VPS26C	psi-mi:“MI:0914”(association)	0.350

BioGRID (22): COMMD7 (Affinity Capture-MS), COMMD2 (Affinity Capture-MS), COMMD5 (Affinity Capture-MS), MED29 (Affinity Capture-MS), COMMD4 (Affinity Capture-MS), ACTBL2 (Affinity Capture-MS), COMMD6 (Affinity Capture-MS), EEF1A2 (Affinity Capture-MS), SEMG2 (Affinity Capture-MS), CCDC22 (Affinity Capture-MS), COMMD1 (Affinity Capture-MS), ORAOV1 (Affinity Capture-MS), BEND6 (Affinity Capture-MS), CCDC93 (Affinity Capture-MS), C16orf62 (Affinity Capture-MS)

ESM2 similar proteins: O95007, P0C7N1, P0DN81, P34986, P37067, P37068, P37069, P37070, P37071, Q60893, Q6IFH4, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NGE1, Q8NGG0, Q8NGG1, Q8NGG4, Q8NGI9, Q8NGL2, Q8NGP2, Q8NGQ6, Q8NGS4, Q8NGS7, Q8NGZ3, Q8NGZ9, Q8NH01, Q8NHC8, Q8VES2, Q8VEW5, Q8VEZ0, Q8VF65, Q8VF66, Q8VF76, Q8VFD2, Q8VFM9, Q8VFX2, Q8VG02, Q8VG04

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NL26, A6NMZ5, O43749, O95013, P0C604, P0C623, P0C645, P0DMU2, P0DN82, P34985, P58180, Q13606, Q15615, Q60878, Q60881, Q60886, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

417 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247672763:G:GA	donor_gain	0.8000
1:247672852:CCAG:C	acceptor_gain	0.7900
1:247672853:CAG:C	acceptor_gain	0.7800
1:247672977:C:A	donor_gain	0.7800
1:247672762:AG:A	donor_gain	0.7700
1:247672476:A:AC	donor_gain	0.7500
1:247672477:C:CC	donor_gain	0.7500
1:247672854:A:T	acceptor_gain	0.7300
1:247672976:T:TA	donor_gain	0.7300
1:247672855:G:GC	acceptor_gain	0.7100
1:247673021:A:AC	donor_gain	0.7100
1:247673026:CAACG:C	donor_gain	0.7100
1:247672859:C:CT	acceptor_gain	0.7000
1:247672974:ATTC:A	donor_gain	0.6900
1:247673025:A:AC	donor_gain	0.6900
1:247673026:C:CC	donor_gain	0.6900
1:247672509:AT:A	donor_gain	0.6700
1:247672693:AGG:A	donor_gain	0.6600
1:247672357:CTA:C	acceptor_gain	0.6500
1:247672514:A:AC	donor_gain	0.6500
1:247672515:C:CC	donor_gain	0.6500
1:247672855:G:C	acceptor_gain	0.6500
1:247672973:AATTC:A	donor_gain	0.6400
1:247673026:CAA:C	donor_gain	0.6400
1:247672360:C:CC	acceptor_gain	0.6300
1:247672456:CCA:C	donor_gain	0.6300
1:247673022:G:C	donor_gain	0.6300
1:247672385:A:T	acceptor_gain	0.6200
1:247672382:A:T	acceptor_gain	0.6100
1:247672860:A:T	acceptor_gain	0.6100

AlphaMissense

2035 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247673015:G:C	F9L	0.935
1:247673015:G:T	F9L	0.935
1:247673017:A:G	F9L	0.935
1:247672547:G:C	F165L	0.905
1:247672547:G:T	F165L	0.905
1:247672549:A:G	F165L	0.905
1:247672337:G:C	F235L	0.855
1:247672337:G:T	F235L	0.855
1:247672339:A:G	F235L	0.855
1:247672745:G:C	F99L	0.855
1:247672745:G:T	F99L	0.855
1:247672747:A:G	F99L	0.855
1:247672823:G:C	S73R	0.838
1:247672823:G:T	S73R	0.838
1:247672825:T:G	S73R	0.838
1:247672520:G:C	F174L	0.834
1:247672520:G:T	F174L	0.834
1:247672522:A:G	F174L	0.834
1:247672517:G:C	F175L	0.818
1:247672517:G:T	F175L	0.818
1:247672519:A:G	F175L	0.818
1:247673016:A:G	F9S	0.815
1:247672584:G:A	S153F	0.799
1:247672739:G:C	F101L	0.799
1:247672739:G:T	F101L	0.799
1:247672741:A:G	F101L	0.799
1:247672686:C:G	R119P	0.793
1:247672178:G:C	S288R	0.781
1:247672178:G:T	S288R	0.781
1:247672180:T:G	S288R	0.781

dbSNP variants (sampled 300 via entrez): RS1000757162 (1:247678313 T>C), RS1000833761 (1:247680274 A>T), RS1000886917 (1:247674988 T>C), RS1000923370 (1:247671691 T>G), RS1001140421 (1:247678622 C>T), RS1001662237 (1:247670982 G>A), RS1001713172 (1:247670654 AAT>A), RS1001929508 (1:247676383 T>C), RS1002167263 (1:247676726 A>G), RS1002313717 (1:247678943 T>A), RS1002454610 (1:247676947 A>G), RS1002756274 (1:247679581 C>T), RS1003654910 (1:247671752 A>G), RS1003722736 (1:247673749 T>C), RS1004339032 (1:247671082 C>T)

Disease associations

OMIM: gene MIM:611677 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.