OR13J1

Summary

OR13J1 (olfactory receptor family 13 subfamily J member 1, HGNC:15108) is a protein-coding gene on chromosome 9p13.3, encoding Olfactory receptor 13J1 (Q8NGT2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 392309 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 62 total
• MANE Select transcript: NM_001004487

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15108
Approved symbol	OR13J1
Name	olfactory receptor family 13 subfamily J member 1
Location	9p13.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000168828
Ensembl biotype	protein_coding
Entrez	392309

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000377981

RefSeq mRNA: 1 — MANE Select: NM_001004487 NM_001004487

CCDS: CCDS35011

Canonical transcript exons

ENST00000377981 — 1 exons

Exon	Start	End
ENSE00001475746	35869463	35870401

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 53.83.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	53.83	gold quality
sural nerve	UBERON:0015488	53.81	gold quality
primary visual cortex	UBERON:0002436	53.17	gold quality
frontal cortex	UBERON:0001870	52.54	gold quality
anterior cingulate cortex	UBERON:0009835	51.78	gold quality
cerebral cortex	UBERON:0000956	51.48	gold quality
Ammon’s horn	UBERON:0001954	51.38	gold quality
right frontal lobe	UBERON:0002810	51.19	gold quality
superior frontal gyrus	UBERON:0002661	51.08	gold quality
putamen	UBERON:0001874	50.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	50.55	gold quality
temporal lobe	UBERON:0001871	50.20	gold quality
amygdala	UBERON:0001876	49.92	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.84	gold quality
caudate nucleus	UBERON:0001873	49.27	gold quality
cortical plate	UBERON:0005343	49.27	gold quality
nucleus accumbens	UBERON:0001882	49.03	gold quality
brain	UBERON:0000955	48.10	gold quality
skeletal muscle tissue	UBERON:0001134	47.35	silver quality
hindlimb stylopod muscle	UBERON:0004252	47.31	silver quality
hypothalamus	UBERON:0001898	46.16	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	45.85	gold quality
cerebellum	UBERON:0002037	44.43	gold quality
cerebellar cortex	UBERON:0002129	44.16	gold quality
cerebellar hemisphere	UBERON:0002245	44.07	gold quality
substantia nigra	UBERON:0002038	43.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	43.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	42.87	gold quality
lower esophagus	UBERON:0013473	42.75	gold quality
muscle tissue	UBERON:0002385	42.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or13j1	ENSMUSG00000046450
rattus_norvegicus	Or13j1	ENSRNOG00000082595

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 13J1 — Q8NGT2 (reviewed: Q8NGT2)

Alternative names: Olfactory receptor OR9-2

All UniProt accessions (1): Q8NGT2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004487* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGT2-F1	82.07	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 191

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 28 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, chr9p13, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE17721_CTRL_VS_CPG_0.5H_BMDC_UP, GSE17721_LPS_VS_POLYIC_6H_BMDC_UP, GSE17721_POLYIC_VS_CPG_0.5H_BMDC_UP, GSE17721_LPS_VS_CPG_0.5H_BMDC_DN

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR13J1	KRTAP19-7	Q3SYF9	581
OR13J1	FAM181A	Q8N9Y4	506
OR13J1	SYNGR4	O95473	468
OR13J1	ZNF781	Q8N8C0	435
OR13J1	FTHL17	Q9BXU8	417
OR13J1	PCDHGB4	Q9UN71	417
OR13J1	STON1	Q9Y6Q2	400
OR13J1	PHETA1	Q8N4B1	398
OR13J1	EFR3A	Q14156	380
OR13J1	KRT84	Q9NSB2	375
OR13J1	UNC79	Q9P2D8	372
OR13J1	NMBR	P28336	372
OR13J1	KIF25	Q9UIL4	370
OR13J1	ADGRF4	Q8IZF3	369
OR13J1	MTFR2	Q6P444	366

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR13J1	FZD7	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): CCPG1 (Affinity Capture-MS), FZD7 (Affinity Capture-MS), MOSPD2 (Affinity Capture-MS), GOLGA5 (Affinity Capture-MS), ATP2B3 (Affinity Capture-MS), SLC41A3 (Affinity Capture-MS), SARAF (Affinity Capture-MS), HMGCR (Affinity Capture-MS)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

58 predictions. Top by Δscore:

Variant	Effect	Δscore
9:35869495:T:A	donor_gain	0.6200
9:35869515:T:TA	donor_gain	0.5900
9:35869820:G:T	donor_gain	0.5300
9:35869909:T:TA	acceptor_gain	0.5200
9:35869880:G:T	donor_gain	0.5100
9:35869510:TC:T	donor_gain	0.4900
9:35869827:G:C	donor_gain	0.4900
9:35869605:T:TA	donor_gain	0.4700
9:35869506:T:TA	donor_gain	0.4600
9:35869610:A:AC	donor_gain	0.4600
9:35869611:C:CC	donor_gain	0.4600
9:35869611:CT:C	donor_gain	0.4300
9:35869823:CGACG:C	donor_gain	0.4300
9:35869660:C:CT	donor_gain	0.4200
9:35869661:T:TT	donor_gain	0.4200
9:35869699:A:AC	donor_gain	0.4100
9:35869579:TGAAG:T	donor_gain	0.4000
9:35869910:C:A	acceptor_gain	0.3900
9:35869505:CTCCT:C	donor_gain	0.3800
9:35869506:TCCTT:T	donor_gain	0.3800
9:35869507:CCTTC:C	donor_gain	0.3800
9:35869629:A:C	donor_gain	0.3800
9:35869698:CA:C	donor_gain	0.3800
9:35869606:C:A	donor_gain	0.3500
9:35869701:C:T	donor_gain	0.3500
9:35869929:G:C	donor_gain	0.3500
9:35869508:CT:C	donor_gain	0.3400
9:35869509:TTC:T	donor_gain	0.3400
9:35869824:G:T	donor_gain	0.3100
9:35869934:CGACT:C	acceptor_gain	0.3000

AlphaMissense

2008 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:35870366:G:C	F12L	0.837
9:35870366:G:T	F12L	0.837
9:35870368:A:G	F12L	0.837
9:35869871:G:C	F177L	0.735
9:35869871:G:T	F177L	0.735
9:35869873:A:G	F177L	0.735
9:35869898:G:C	F168L	0.705
9:35869898:G:T	F168L	0.705
9:35869900:A:G	F168L	0.705
9:35870351:A:C	F17L	0.704
9:35870351:A:T	F17L	0.704
9:35870353:A:G	F17L	0.704
9:35870120:A:C	F94L	0.703
9:35870120:A:T	F94L	0.703
9:35870122:A:G	F94L	0.703
9:35869649:G:C	F251L	0.665
9:35869649:G:T	F251L	0.665
9:35869651:A:G	F251L	0.665
9:35870171:A:C	F77L	0.640
9:35870171:A:T	F77L	0.640
9:35870173:A:G	F77L	0.640
9:35870318:G:C	F28L	0.617
9:35870318:G:T	F28L	0.617
9:35870320:A:G	F28L	0.617
9:35869688:G:C	F238L	0.614
9:35869688:G:T	F238L	0.614
9:35869690:A:G	F238L	0.614
9:35870219:G:C	F61L	0.573
9:35870219:G:T	F61L	0.573
9:35870221:A:G	F61L	0.573

dbSNP variants (sampled 300 via entrez): RS1000097909 (9:35869171 C>G), RS1001883133 (9:35872015 A>C), RS1002813887 (9:35871781 G>T), RS1002990280 (9:35871087 C>G), RS1004991538 (9:35869159 A>T), RS1005619749 (9:35872238 C>G), RS1006290910 (9:35872314 A>C,G), RS1008291873 (9:35869037 G>A), RS1009637855 (9:35872049 T>C), RS1011415159 (9:35871416 A>T), RS1011528759 (9:35870971 G>A,C), RS1011736967 (9:35871131 A>G), RS1012526917 (9:35869523 C>T), RS1012907826 (9:35870752 A>G), RS1013458570 (9:35870469 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Plant Extracts	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.