OR14A2

Summary

OR14A2 (olfactory receptor family 14 subfamily A member 2, HGNC:15024) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 14A2 (Q96R54). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 388761 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001355292

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15024
Approved symbol	OR14A2
Name	olfactory receptor family 14 subfamily A member 2
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000241128
Ensembl biotype	protein_coding
Entrez	388761

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 nonsense_mediated_decay

ENST00000366485, ENST00000426444

RefSeq mRNA: 1 — MANE Select: NM_001355292 NM_001355292

CCDS: CCDS86063

Canonical transcript exons

ENST00000366485 — 5 exons

Exon	Start	End
ENSE00001441824	247722957	247724062
ENSE00003998137	247734186	247734425
ENSE00003998138	247735484	247735556
ENSE00003998139	247747871	247748141
ENSE00003998140	247733283	247733383

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 81.85.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.85	gold quality
left testis	UBERON:0004533	58.58	gold quality
testis	UBERON:0000473	58.39	gold quality
right testis	UBERON:0004534	56.12	gold quality
colonic epithelium	UBERON:0000397	42.30	gold quality
bone marrow cell	CL:0002092	41.27	gold quality
sural nerve	UBERON:0015488	40.57	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	35.54	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
adrenal tissue	UBERON:0018303	34.60	gold quality
bone marrow	UBERON:0002371	34.35	gold quality
muscle tissue	UBERON:0002385	32.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
right uterine tube	UBERON:0001302	31.34	gold quality
corpus callosum	UBERON:0002336	30.54	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.44	gold quality
leukocyte	CL:0000738	29.27	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
tonsil	UBERON:0002372	29.19	gold quality
liver	UBERON:0002107	28.89	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.43	gold quality
urinary bladder	UBERON:0001255	26.80	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or14a259	ENSMUSG00000055571
mus_musculus	Or14a260	ENSMUSG00000055610
mus_musculus	Or14a256	ENSMUSG00000062042
mus_musculus	Or14a258	ENSMUSG00000062426
mus_musculus	Or14a257	ENSMUSG00000062878
rattus_norvegicus	Or14a257c	ENSRNOG00000076384
rattus_norvegicus	Or14a260	ENSRNOG00000077866
rattus_norvegicus	Or14a257	ENSRNOG00000080972
rattus_norvegicus	Or14a258	ENSRNOG00000082349
rattus_norvegicus	Or14a257b	ENSRNOG00000087447
rattus_norvegicus	Or14a257d	ENSRNOG00000088522

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 14A2 — Q96R54 (reviewed: Q96R54)

Alternative names: Olfactory receptor 5AX1, Olfactory receptor OR1-31

All UniProt accessions (3): Q96R54, A0A126GWG8, A0A286YFD4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001342221* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R54-F1	87.00	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–177

Glycosylation sites (2): 3, 83

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

82 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR14A2	FAM131A	Q6UXB0	348
OR14A2	ZNF429	Q86V71	287
OR14A2	GCSAML	Q5JQS6	285
OR14A2	ZSCAN20	P17040	251
OR14A2	ALDH18A1	P54886	240
OR14A2	OR52N1	Q8NH53	232
OR14A2	GRID2IP	A4D2P6	199
OR14A2	SNX8	Q9Y5X2	192
OR14A2	MAPK1	P28482	191
OR14A2	RFFL	Q8WZ73	189
OR14A2	CYP4F22	Q6NT55	174
OR14A2	TRIM58	Q8NG06	167
OR14A2	LCLAT1	Q6UWP7	166
OR14A2	PYY	P10082	166
OR14A2	NMUR2	Q9GZQ4	158

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0DN80, P23268, P34982, P35898, Q60887, Q60892, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGA0, Q8NGE2, Q8NGF7, Q8NGI8, Q8NGL4, Q8NGS5, Q8NGU1, Q8NGU2, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VF13, Q8VFB9

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

559 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247723841:T:TA	donor_gain	0.9800
1:247723895:T:TA	donor_gain	0.9600
1:247723927:A:AC	donor_gain	0.9500
1:247723928:C:CC	donor_gain	0.9500
1:247723931:A:AC	donor_gain	0.9500
1:247723853:A:AC	donor_gain	0.9400
1:247738780:GCAAT:G	donor_gain	0.9200
1:247738781:C:T	donor_gain	0.9100
1:247738785:G:GG	donor_gain	0.9000
1:247723874:A:C	donor_gain	0.8700
1:247723860:T:TA	donor_gain	0.8600
1:247723932:T:C	donor_gain	0.8600
1:247723390:A:C	acceptor_gain	0.8400
1:247738920:G:GA	donor_gain	0.8400
1:247723869:A:AC	donor_gain	0.8300
1:247723616:G:A	donor_gain	0.8200
1:247738655:G:GT	donor_gain	0.8200
1:247738783:AT:A	donor_gain	0.8200
1:247723394:A:C	acceptor_gain	0.8000
1:247723394:A:AC	acceptor_gain	0.7700
1:247723894:G:C	donor_gain	0.7700
1:247723268:T:TG	acceptor_gain	0.7600
1:247723405:C:CT	acceptor_gain	0.7600
1:247723924:G:C	donor_gain	0.7500
1:247723853:AAGTT:A	donor_gain	0.7400
1:247738778:T:A	donor_gain	0.7400
1:247723379:G:GC	acceptor_gain	0.7300
1:247723646:ATTAC:A	donor_loss	0.7100
1:247723647:TTAC:T	donor_loss	0.7100
1:247723648:TACC:T	donor_loss	0.7100

AlphaMissense

2043 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247724014:A:C	F10L	0.868
1:247724014:A:T	F10L	0.868
1:247724016:A:G	F10L	0.868
1:247723558:A:C	F162L	0.842
1:247723558:A:T	F162L	0.842
1:247723560:A:G	F162L	0.842
1:247723297:A:C	F249L	0.776
1:247723297:A:T	F249L	0.776
1:247723299:A:G	F249L	0.776
1:247723516:G:C	F176L	0.769
1:247723516:G:T	F176L	0.769
1:247723518:A:G	F176L	0.769
1:247723867:G:C	F59L	0.769
1:247723867:G:T	F59L	0.769
1:247723869:A:G	F59L	0.769
1:247723336:A:C	F236L	0.765
1:247723336:A:T	F236L	0.765
1:247723338:A:G	F236L	0.765
1:247723546:G:C	F166L	0.764
1:247723546:G:T	F166L	0.764
1:247723548:A:G	F166L	0.764
1:247723519:A:C	F175L	0.761
1:247723519:A:T	F175L	0.761
1:247723521:A:G	F175L	0.761
1:247723957:G:C	F29L	0.758
1:247723957:G:T	F29L	0.758
1:247723959:A:G	F29L	0.758
1:247723685:C:G	R120P	0.742
1:247723177:G:C	S289R	0.705
1:247723177:G:T	S289R	0.705

dbSNP variants (sampled 300 via entrez): RS1000096821 (1:247740706 T>C), RS1000350820 (1:247725386 A>G), RS1000390424 (1:247725112 T>C), RS1000419234 (1:247724757 A>G), RS1000585150 (1:247741480 A>G), RS1000754407 (1:247727376 T>C), RS1000855364 (1:247733518 C>T), RS1000995271 (1:247739985 A>G), RS1001005631 (1:247734145 A>G), RS1001391189 (1:247733174 T>G), RS1001518105 (1:247736138 A>G), RS1001529907 (1:247725514 TTTTTTATTTATTTA>T), RS1001562323 (1:247725268 A>G), RS1001621347 (1:247742476 A>G), RS1001718287 (1:247747120 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.