OR14C36

Summary

OR14C36 (olfactory receptor family 14 subfamily C member 36, HGNC:15026) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 14C36 (Q8NHC7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127066 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_001001918

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15026
Approved symbol	OR14C36
Name	olfactory receptor family 14 subfamily C member 36
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177174
Ensembl biotype	protein_coding
Entrez	127066

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000317861

RefSeq mRNA: 1 — MANE Select: NM_001001918 NM_001001918

CCDS: CCDS31112

Canonical transcript exons

ENST00000317861 — 1 exons

Exon	Start	End
ENSE00001277275	248348775	248349713

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 37.20.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	31.03	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
liver	UBERON:0002107	28.61	gold quality
monocyte	CL:0000576	28.43	gold quality
leukocyte	CL:0000738	28.35	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.80	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.89	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.25	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
frontal cortex	UBERON:0001870	25.64	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or14c43	ENSMUSG00000020168
mus_musculus	Or14c45	ENSMUSG00000057067
mus_musculus	Or14c46	ENSMUSG00000057540
mus_musculus	Or14c41	ENSMUSG00000059319
mus_musculus	Or14c39	ENSMUSG00000060688
mus_musculus	Or14c44	ENSMUSG00000061549
mus_musculus	Or14c40	ENSMUSG00000063394
mus_musculus	Or14c42	ENSMUSG00000092372
mus_musculus	Or14n1	ENSMUSG00000092401
rattus_norvegicus	Or14c39b	ENSRNOG00000029233
rattus_norvegicus	Or14n1	ENSRNOG00000076037
rattus_norvegicus	Or14c40	ENSRNOG00000081552
rattus_norvegicus	Or14c43	ENSRNOG00000084504
rattus_norvegicus	Or14c39	ENSRNOG00000090780

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 14C36 — Q8NHC7 (reviewed: Q8NHC7)

Alternative names: Olfactory receptor 5BF1, Olfactory receptor OR1-59

All UniProt accessions (1): Q8NHC7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001918* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NHC7-F1	86.83	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, MATSUMIYA_PBMC_MODIFIED_VACCINIA_ANKARA_VACCINE_AGE_18_55YO_VACCINATED_VS_CONTROL_TREATED_IN_VITRO_WITH_WILD_TYPE_MVA_6HR_UP, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR14C36	LENG1	Q96BZ8	476
OR14C36	RFX8	Q6ZV50	416
OR14C36	SLC16A13	Q7RTY0	328
OR14C36	KCNRG	Q8N5I3	321
OR14C36	CBLN4	Q9NTU7	303
OR14C36	DOCK11	Q5JSL3	271
OR14C36	DOCK6	Q96HP0	261
OR14C36	ZMYM3	Q14202	259
OR14C36	DOCK10	Q96BY6	259
OR14C36	DOCK9	Q9BZ29	257
OR14C36	COL7A1	Q02388	246
OR14C36	DOCK3	Q8IZD9	244
OR14C36	DNAH11	Q96DT5	235
OR14C36	PRKCSH	P14314	226
OR14C36	ELP3	Q9H9T3	225

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR14C36	HSPD1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): OR14C36 (Proximity Label-MS), OR14C36 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A2R8YED5, A6ND48, B2RN74, O60412, O76099, O76100, O95047, P23271, P23272, P34982, P37069, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGE0, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGS2, Q8NGW1, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07, Q8NH80, Q8NHA4, Q8NHC7, Q8VEY3, Q8VFC9, Q8WZA6

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	42
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

483 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248348960:G:GT	donor_gain	0.7900
1:248349055:G:GT	donor_gain	0.7000
1:248349440:C:A	acceptor_gain	0.7000
1:248349639:A:AG	acceptor_gain	0.7000
1:248349640:G:GG	acceptor_gain	0.7000
1:248349436:C:CA	acceptor_gain	0.6900
1:248349640:GTCTT:G	acceptor_gain	0.6800
1:248348961:A:T	donor_gain	0.6700
1:248349457:G:C	acceptor_gain	0.6700
1:248349442:T:TA	acceptor_gain	0.6600
1:248349447:G:A	acceptor_gain	0.6500
1:248349665:G:GA	donor_gain	0.6500
1:248349579:GATC:G	donor_gain	0.6400
1:248349446:C:A	acceptor_gain	0.6300
1:248349512:GTC:G	donor_gain	0.6300
1:248349222:G:GA	donor_gain	0.6200
1:248349379:TGGGG:T	acceptor_gain	0.6200
1:248349380:GGGGG:G	acceptor_gain	0.6200
1:248349055:G:T	donor_gain	0.6100
1:248349664:T:TA	donor_gain	0.6000
1:248349080:G:GA	donor_gain	0.5900
1:248349640:GT:G	acceptor_gain	0.5900
1:248349279:TCC:T	donor_gain	0.5700
1:248349599:T:G	donor_gain	0.5700
1:248348881:C:G	donor_gain	0.5600
1:248349323:G:GT	donor_gain	0.5600
1:248349456:A:G	acceptor_gain	0.5600
1:248349638:CAG:C	acceptor_gain	0.5600
1:248349052:C:T	donor_gain	0.5500
1:248349071:C:A	donor_gain	0.5500

AlphaMissense

2054 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248348802:T:C	F10L	0.926
1:248348804:T:A	F10L	0.926
1:248348804:T:G	F10L	0.926
1:248349258:T:C	F162L	0.862
1:248349260:C:A	F162L	0.862
1:248349260:C:G	F162L	0.862
1:248349300:T:C	F176L	0.839
1:248349302:C:A	F176L	0.839
1:248349302:C:G	F176L	0.839
1:248349519:T:C	F249L	0.837
1:248349521:C:A	F249L	0.837
1:248349521:C:G	F249L	0.837
1:248349297:T:C	F175L	0.830
1:248349299:C:A	F175L	0.830
1:248349299:C:G	F175L	0.830
1:248349270:T:C	F166L	0.818
1:248349272:C:A	F166L	0.818
1:248349272:C:G	F166L	0.818
1:248348817:T:C	F15L	0.805
1:248348819:T:A	F15L	0.805
1:248348819:T:G	F15L	0.805
1:248349072:T:C	F100L	0.787
1:248349074:C:A	F100L	0.787
1:248349074:C:G	F100L	0.787
1:248349639:A:C	S289R	0.785
1:248349641:T:A	S289R	0.785
1:248349641:T:G	S289R	0.785
1:248349219:A:C	S149R	0.767
1:248349221:T:A	S149R	0.767
1:248349221:T:G	S149R	0.767

dbSNP variants (sampled 300 via entrez): RS1000121666 (1:248348663 A>G), RS1001744973 (1:248349726 G>A,C), RS1005517285 (1:248349472 C>A,G), RS1005852782 (1:248347987 C>T), RS1007659917 (1:248347940 A>G), RS1008989469 (1:248349054 G>A), RS1011708785 (1:248347320 T>C), RS1012637004 (1:248347024 A>G), RS1013898600 (1:248348283 C>A), RS1014590686 (1:248347993 A>C), RS1016936105 (1:248349478 C>A,G), RS1018544688 (1:248349576 C>T), RS1019700534 (1:248350170 G>A), RS1020509577 (1:248347034 G>T), RS1021017373 (1:248348423 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Benzo(a)pyrene	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.