OR14K1

Summary

OR14K1 (olfactory receptor family 14 subfamily K member 1, HGNC:15025) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 14K1 (Q8NGZ2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 343170 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001004732

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15025
Approved symbol	OR14K1
Name	olfactory receptor family 14 subfamily K member 1
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000153230
Ensembl biotype	protein_coding
Entrez	343170

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000283225

RefSeq mRNA: 1 — MANE Select: NM_001004732 NM_001004732

CCDS: CCDS86064

Canonical transcript exons

ENST00000283225 — 1 exons

Exon	Start	End
ENSE00001009576	247738615	247739559

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 82.88.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.88	gold quality
sural nerve	UBERON:0015488	50.50	gold quality
bone marrow cell	CL:0002092	43.58	gold quality
bone marrow	UBERON:0002371	39.40	silver quality
right uterine tube	UBERON:0001302	37.32	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
muscle tissue	UBERON:0002385	32.32	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	30.52	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
endometrium	UBERON:0001295	29.44	gold quality
liver	UBERON:0002107	29.40	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
monocyte	CL:0000576	29.06	gold quality
gall bladder	UBERON:0002110	29.04	silver quality
leukocyte	CL:0000738	28.93	gold quality
smooth muscle tissue	UBERON:0001135	28.16	gold quality
duodenum	UBERON:0002114	28.14	gold quality
uterine cervix	UBERON:0000002	27.67	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.63	silver quality
lymph node	UBERON:0000029	27.57	gold quality
fallopian tube	UBERON:0003889	26.89	silver quality
blood	UBERON:0000178	26.88	gold quality
endocervix	UBERON:0000458	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
placenta	UBERON:0001987	25.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 14K1 — Q8NGZ2 (reviewed: Q8NGZ2)

Alternative names: Olfactory receptor 5AY1, Olfactory receptor OR1-39

All UniProt accessions (1): Q8NGZ2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004732* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGZ2-F1	83.28	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

80 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR14K1	RTP1	P59025	408
OR14K1	TAS2R60	P59551	305
OR14K1	RNF213	Q63HN8	294
OR14K1	ZFHX3	Q15911	248
OR14K1	FAT4	Q6V0I7	247
OR14K1	RIC8B	Q9NVN3	233
OR14K1	OR5H15	A6NDH6	213
OR14K1	OR13H1	Q8NG92	202
OR14K1	POLE	Q07864	201
OR14K1	KMT2D	O14686	180
OR14K1	OR1L3	Q8NH93	180
OR14K1	KMT2C	Q8NEZ4	174
OR14K1	OR5H14	A6NHG9	162
OR14K1	OR5H6	Q8NGV6	155
OR14K1	OR5AC2	Q9NZP5	151

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6ND48, B2RN74, O60412, O76099, O76100, O95047, P23271, P23272, P34982, P37069, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGE0, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGS2, Q8NGW1, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07, Q8NH80, Q8NHA4, Q8NHC7, Q8VEY3, Q8VFC9, Q8WZA6

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

311 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247738780:GCAAT:G	donor_gain	0.9200
1:247738781:C:T	donor_gain	0.9100
1:247738785:G:GG	donor_gain	0.9000
1:247738920:G:GA	donor_gain	0.8400
1:247738655:G:GT	donor_gain	0.8200
1:247738783:AT:A	donor_gain	0.8200
1:247738778:T:A	donor_gain	0.7400
1:247738784:TGTAC:T	donor_loss	0.7100
1:247738785:GTA:G	donor_loss	0.7100
1:247738786:T:G	donor_loss	0.7000
1:247738777:AT:A	donor_gain	0.6900
1:247738787:A:C	donor_loss	0.6400
1:247738919:T:TA	donor_gain	0.6400
1:247739202:C:A	donor_gain	0.6000
1:247739093:G:GT	donor_gain	0.5900
1:247739419:GACTT:G	acceptor_gain	0.5800
1:247738651:G:GG	donor_gain	0.5700
1:247739200:GTC:G	donor_gain	0.5700
1:247738892:TGGGG:T	acceptor_gain	0.5600
1:247739223:T:G	donor_gain	0.5600
1:247738775:ACAT:A	donor_gain	0.5500
1:247739418:A:AG	acceptor_gain	0.5500
1:247739419:G:GG	acceptor_gain	0.5500
1:247739123:A:G	donor_gain	0.5400
1:247739198:GT:G	donor_gain	0.5400
1:247739128:C:G	donor_gain	0.5300
1:247738899:T:A	donor_gain	0.5200
1:247738650:T:TG	donor_gain	0.5100
1:247739213:TTGGG:T	donor_loss	0.5100
1:247739216:GGGT:G	donor_loss	0.5100

AlphaMissense

2032 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247738642:T:C	F10L	0.817
1:247738644:C:A	F10L	0.817
1:247738644:C:G	F10L	0.817
1:247739098:T:C	F162L	0.814
1:247739100:C:A	F162L	0.814
1:247739100:C:G	F162L	0.814
1:247739137:T:C	F175L	0.778
1:247739139:C:A	F175L	0.778
1:247739139:C:G	F175L	0.778
1:247739140:T:C	F176L	0.765
1:247739142:C:A	F176L	0.765
1:247739142:C:G	F176L	0.765
1:247739359:T:C	F249L	0.764
1:247739361:T:A	F249L	0.764
1:247739361:T:G	F249L	0.764
1:247738699:T:C	F29L	0.755
1:247738701:C:A	F29L	0.755
1:247738701:C:G	F29L	0.755
1:247738657:T:C	F15L	0.698
1:247738659:T:A	F15L	0.698
1:247738659:T:G	F15L	0.698
1:247739320:T:C	F236L	0.684
1:247739322:T:A	F236L	0.684
1:247739322:T:G	F236L	0.684
1:247739110:T:C	F166L	0.633
1:247739112:T:A	F166L	0.633
1:247739112:T:G	F166L	0.633
1:247739272:T:C	F220L	0.599
1:247739274:C:A	F220L	0.599
1:247739274:C:G	F220L	0.599

dbSNP variants (sampled 300 via entrez): RS1000995271 (1:247739985 A>G), RS1003590826 (1:247737763 C>T), RS1003859464 (1:247737071 A>C), RS1004814410 (1:247736790 A>T), RS1007207744 (1:247740022 T>C), RS1008364761 (1:247736644 A>T), RS1008812227 (1:247736987 G>A), RS1010648032 (1:247738116 A>C), RS1011263302 (1:247737524 A>G), RS1011294410 (1:247737232 CTGTGTG>C,CTGTG,CTGTGTGTG), RS1012309849 (1:247739663 T>C,G), RS1014282695 (1:247737643 A>G), RS1014586677 (1:247739743 T>A), RS1016291848 (1:247737966 A>T), RS1016621257 (1:247739776 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Diethylhexyl Phthalate	decreases expression	1
Thiram	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.