OR1D5

Summary

OR1D5 (olfactory receptor family 1 subfamily D member 5, HGNC:8186) is a protein-coding gene on chromosome 17p13.3, encoding Olfactory receptor 1D5 (P58170). Odorant receptor. It is a selective cancer dependency (DepMap: 14.6% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 8386 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 56 total
• Cancer dependency (DepMap): dependent in 14.6% of screened cell lines
• MANE Select transcript: NM_014566

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8186
Approved symbol	OR1D5
Name	olfactory receptor family 1 subfamily D member 5
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	OR17-31
Ensembl gene	ENSG00000262628
Ensembl biotype	protein_coding
Entrez	8386

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000575751

RefSeq mRNA: 2 — MANE Select: NM_014566 NM_003552, NM_014566

CCDS: CCDS58499

Canonical transcript exons

ENST00000575751 — 1 exons

Exon	Start	End
ENSE00002651600	3062669	3063607

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 93.45.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.45	gold quality
sural nerve	UBERON:0015488	41.77	gold quality
bone marrow cell	CL:0002092	38.54	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.27	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.61	gold quality
corpus callosum	UBERON:0002336	29.03	gold quality
liver	UBERON:0002107	28.28	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.82	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.19	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.84	gold quality
blood	UBERON:0000178	26.61	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
leukocyte	CL:0000738	26.53	gold quality
monocyte	CL:0000576	26.43	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
calcaneal tendon	UBERON:0003701	25.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 14.6% of screened cell lines.

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 1D5 — P58170 (reviewed: P58170)

Alternative names: Olfactory receptor 17-31

All UniProt accessions (2): A0A126GVQ6, P58170

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_003543, NP_055381* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P58170-F1	80.93	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, WP_GPCRS_CLASS_A_RHODOPSINLIKE, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

250 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1D5	KRTAP9-7	A8MTY7	620
OR1D5	KRTAP9-8	Q9BYQ0	528
OR1D5	OTOL1	A6NHN0	522
OR1D5	KRTAP9-1	A8MXZ3	480
OR1D5	TMEM95	Q3KNT9	447
OR1D5	TMEM220	Q6QAJ8	419
OR1D5	C17orf50	Q8WW18	417
OR1D5	OR2AG1	Q9H205	405
OR1D5	TBC1D3K	A0A087X1G2	397
OR1D5	LIPG	Q9Y5X9	375
OR1D5	OTOP2	Q7RTS6	374
OR1D5	CDRT15L2	A8MXV6	370
OR1D5	TMEM92	Q6UXU6	368
OR1D5	TBC1D3H	P0C7X1	324
OR1D5	CFAP97D1	B2RV13	321

IntAct

3 interactions, top by confidence:

A	B	Type	Score
	OR1D5	psi-mi:“MI:0915”(physical association)	0.490

BioGRID (1): OR1D5 (Two-hybrid)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: O14581, O43749, O60412, O60431, O76001, O76099, O76100, P0DN82, P23265, P23266, P23268, P23269, P23271, P23272, P23273, P23274, P30953, P30955, P34982, P34987, P35896, P35898, P35899, P47881, P47884, P47887, P47888, P47890, P58170, P58173, P59922, P70526, Q0VAX9, Q15619, Q15620, Q15622, Q60879, Q60882, Q60884, Q60890

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

238 predictions. Top by Δscore:

Variant	Effect	Δscore
17:3063251:CGCCA:C	donor_gain	0.9500
17:3063242:G:C	donor_gain	0.8500
17:3062745:A:AC	acceptor_gain	0.7600
17:3063253:C:CA	donor_gain	0.7300
17:3062735:CAGC:C	acceptor_gain	0.7100
17:3063246:T:TA	donor_gain	0.7100
17:3062745:A:C	acceptor_gain	0.6900
17:3062736:AGCCT:A	acceptor_loss	0.6800
17:3062737:GCCTG:G	acceptor_loss	0.6800
17:3062738:CCTGT:C	acceptor_loss	0.6800
17:3062739:C:CC	acceptor_gain	0.6800
17:3062739:C:CG	acceptor_loss	0.6800
17:3062740:T:A	acceptor_loss	0.6800
17:3062952:A:AC	donor_gain	0.6700
17:3062953:C:CC	donor_gain	0.6700
17:3063320:C:CA	donor_gain	0.6700
17:3063251:CG:C	donor_gain	0.6500
17:3062953:CA:C	donor_gain	0.6400
17:3062780:CATCA:C	donor_gain	0.6300
17:3063201:ATGG:A	donor_gain	0.6100
17:3063282:G:C	donor_gain	0.6000
17:3062780:CA:C	donor_gain	0.5900
17:3063250:ACG:A	donor_gain	0.5900
17:3063251:CGC:C	donor_gain	0.5900
17:3062737:GC:G	acceptor_gain	0.5700
17:3062738:CC:C	acceptor_gain	0.5700
17:3062953:CATA:C	donor_gain	0.5700
17:3062675:AGG:A	donor_gain	0.5600
17:3062784:A:AC	donor_gain	0.5600
17:3062785:C:CC	donor_gain	0.5600

AlphaMissense

2038 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:3063572:G:C	F12L	0.836
17:3063572:G:T	F12L	0.836
17:3063574:A:G	F12L	0.836
17:3063515:G:C	F31L	0.801
17:3063515:G:T	F31L	0.801
17:3063517:A:G	F31L	0.801
17:3063104:G:C	F168L	0.787
17:3063104:G:T	F168L	0.787
17:3063106:A:G	F168L	0.787
17:3063074:G:C	F178L	0.746
17:3063074:G:T	F178L	0.746
17:3063076:A:G	F178L	0.746
17:3062855:A:C	F251L	0.741
17:3062855:A:T	F251L	0.741
17:3062857:A:G	F251L	0.741
17:3063524:A:C	F28L	0.737
17:3063524:A:T	F28L	0.737
17:3063526:A:G	F28L	0.737
17:3062894:G:C	F238L	0.662
17:3062894:G:T	F238L	0.662
17:3062896:A:G	F238L	0.662
17:3062747:G:C	F287L	0.654
17:3062747:G:T	F287L	0.654
17:3062749:A:G	F287L	0.654
17:3063422:G:C	F62L	0.569
17:3063422:G:T	F62L	0.569
17:3063424:A:G	F62L	0.569
17:3063254:C:A	M118I	0.566
17:3063254:C:G	M118I	0.566
17:3063254:C:T	M118I	0.566

dbSNP variants (sampled 300 via entrez): RS1001165709 (17:3063835 T>C), RS1001263129 (17:3063412 G>A), RS1003105843 (17:3064040 A>G), RS1005005621 (17:3064557 C>T), RS1008933160 (17:3062424 G>A), RS1012174044 (17:3064442 G>C), RS1012206576 (17:3063930 G>T), RS1015449790 (17:3064060 C>T), RS1015834559 (17:3064580 A>G), RS1019318254 (17:3064758 G>A,C), RS1020943965 (17:3062442 C>A), RS1024991052 (17:3063961 C>A,T), RS1025023573 (17:3063452 A>G,T), RS1026845998 (17:3065590 G>A), RS1026878704 (17:3064673 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST012020_158	Serum metabolite levels	7.000000e-11
GCST012021_83	Serum metabolite levels	7.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
hydroxyhydroquinone	decreases expression	1
potassium chromate(VI)	decreases expression	1
Cadmium	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.