OR1E2

Summary

OR1E2 (olfactory receptor family 1 subfamily E member 2, HGNC:8190) is a protein-coding gene on chromosome 17p13.2, encoding Olfactory receptor 1E2 (P47887). Odorant receptor. It is a selective cancer dependency (DepMap: 11.2% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 8388 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 56 total
• Cancer dependency (DepMap): dependent in 11.2% of screened cell lines
• MANE Select transcript: NM_003554

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8190
Approved symbol	OR1E2
Name	olfactory receptor family 1 subfamily E member 2
Location	17p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OR17-93, OR17-135
Ensembl gene	ENSG00000127780
Ensembl biotype	protein_coding
Entrez	8388

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000248384

RefSeq mRNA: 1 — MANE Select: NM_003554 NM_003554

CCDS: CCDS11026

Canonical transcript exons

ENST00000248384 — 1 exons

Exon	Start	End
ENSE00000875793	3432870	3433841

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 37.20.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.97	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
superior frontal gyrus	UBERON:0002661	31.27	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
lymph node	UBERON:0000029	30.45	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.52	gold quality
urinary bladder	UBERON:0001255	29.18	gold quality
uterine cervix	UBERON:0000002	28.88	gold quality
monocyte	CL:0000576	28.59	gold quality
leukocyte	CL:0000738	28.50	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.88	gold quality
primary visual cortex	UBERON:0002436	27.87	gold quality
endocervix	UBERON:0000458	27.45	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	26.97	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
corpus callosum	UBERON:0002336	25.43	gold quality
right ovary	UBERON:0002118	25.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 11.2% of screened cell lines.

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 1E2 — P47887 (reviewed: P47887)

Alternative names: Olfactory receptor 17-93/17-135/17-136, Olfactory receptor 1E4

All UniProt accessions (2): P47887, A0A126GW81

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_003545* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence conflict 3, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P47887-F1	85.96	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–198

Glycosylation sites (2): 5, 274

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, NFAT_Q6, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, VANDESLUIS_NORMAL_EMBRYOS_DN, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, WP_GPCRS_CLASS_A_RHODOPSINLIKE, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (5): signal transduction (GO:0007165), sensory perception of chemical stimulus (GO:0007606), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

292 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1E2	KRTAP9-7	A8MTY7	641
OR1E2	KRTAP9-8	Q9BYQ0	570
OR1E2	TRIOBP	Q9H2D6	518
OR1E2	TMCO1	Q9UM00	508
OR1E2	KRTAP9-1	A8MXZ3	507
OR1E2	MINDY4B	A8MYZ0	507
OR1E2	KIAA0319	Q5VV43	507
OR1E2	ZNF562	Q6V9R5	507
OR1E2	TMEM95	Q3KNT9	475
OR1E2	TMEM220	Q6QAJ8	445
OR1E2	IL17RC	Q8NAC3	437
OR1E2	C17orf50	Q8WW18	433
OR1E2	C8orf34	Q49A92	419
OR1E2	TBC1D3K	A0A087X1G2	418
OR1E2	PTPDC1	A2A3K4	410

IntAct

0 interactions, top by confidence:

BioGRID (1): OR1E2 (Affinity Capture-Western)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

272 predictions. Top by Δscore:

Variant	Effect	Δscore
17:3433668:AGG:A	donor_gain	0.7000
17:3433760:A:AC	donor_gain	0.6800
17:3433669:G:C	donor_gain	0.6400
17:3433668:A:AC	donor_gain	0.6300
17:3433665:CA:C	donor_gain	0.6100
17:3433761:G:C	donor_gain	0.6100
17:3433741:A:C	donor_gain	0.6000
17:3433024:G:C	donor_gain	0.5600
17:3433659:CAA:C	donor_gain	0.5600
17:3433660:AAA:A	donor_gain	0.5600
17:3433661:A:AC	donor_gain	0.5600
17:3433219:A:AC	donor_gain	0.5400
17:3433169:C:T	acceptor_gain	0.5300
17:3433518:C:T	acceptor_gain	0.5300
17:3433073:C:CT	donor_gain	0.5200
17:3432901:ATGAC:A	donor_gain	0.4900
17:3432939:CAGG:C	acceptor_gain	0.4900
17:3433116:AC:A	donor_gain	0.4900
17:3433117:CC:C	donor_gain	0.4900
17:3433664:A:AC	donor_gain	0.4900
17:3433665:C:CC	donor_gain	0.4900
17:3432935:T:TA	donor_gain	0.4700
17:3433007:T:G	acceptor_gain	0.4700
17:3433273:A:C	acceptor_gain	0.4600
17:3432898:CAAA:C	donor_gain	0.4500
17:3433234:A:C	donor_gain	0.4500
17:3432943:C:CC	acceptor_gain	0.4400
17:3433518:C:CT	acceptor_gain	0.4400
17:3433118:CCT:C	acceptor_gain	0.4300
17:3433476:G:C	donor_gain	0.4300

AlphaMissense

2123 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:3433806:G:C	F12L	0.870
17:3433806:G:T	F12L	0.870
17:3433808:A:G	F12L	0.870
17:3433311:A:C	F177L	0.860
17:3433311:A:T	F177L	0.860
17:3433313:A:G	F177L	0.860
17:3433284:A:C	F186L	0.801
17:3433284:A:T	F186L	0.801
17:3433286:A:G	F186L	0.801
17:3433062:G:C	F260L	0.782
17:3433062:G:T	F260L	0.782
17:3433064:A:G	F260L	0.782
17:3433281:G:C	F187L	0.747
17:3433281:G:T	F187L	0.747
17:3433283:A:G	F187L	0.747
17:3433749:G:C	F31L	0.705
17:3433749:G:T	F31L	0.705
17:3433751:A:G	F31L	0.705
17:3433506:G:C	S112R	0.698
17:3433506:G:T	S112R	0.698
17:3433508:T:G	S112R	0.698
17:3432951:G:C	F297L	0.694
17:3432951:G:T	F297L	0.694
17:3432953:A:G	F297L	0.694
17:3433521:A:C	F107L	0.665
17:3433521:A:T	F107L	0.665
17:3433523:A:G	F107L	0.665
17:3433628:A:G	C72R	0.660
17:3433370:A:G	W158R	0.653
17:3433370:A:T	W158R	0.653

dbSNP variants (sampled 300 via entrez): RS1000160397 (17:3434197 C>A,G), RS1002450766 (17:3432771 A>G), RS1003704854 (17:3434027 A>G), RS1004641270 (17:3432375 A>T), RS1004713569 (17:3432580 G>A), RS1004723037 (17:3434607 A>G), RS1006260490 (17:3435504 C>T), RS1006291175 (17:3435714 T>G), RS1007268386 (17:3434337 C>T), RS1008565817 (17:3434884 T>C), RS1008951059 (17:3435013 G>A), RS1009241735 (17:3432387 A>C), RS1009619903 (17:3432713 TC>T,TCC), RS1010210628 (17:3433977 T>A,G), RS1011474142 (17:3434935 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Asbestos, Crocidolite	affects expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.