OR1G1

Summary

OR1G1 (olfactory receptor family 1 subfamily G member 1, HGNC:8204) is a protein-coding gene on chromosome 17p13.3, encoding Olfactory receptor 1G1 (P47890). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 8390 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 42 total
• MANE Select transcript: NM_003555

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8204
Approved symbol	OR1G1
Name	olfactory receptor family 1 subfamily G member 1
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	OR17-209
Ensembl gene	ENSG00000183024
Ensembl biotype	protein_coding
Entrez	8390

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000328890

RefSeq mRNA: 1 — MANE Select: NM_003555 NM_003555

CCDS: CCDS11020

Canonical transcript exons

ENST00000328890 — 1 exons

Exon	Start	End
ENSE00003989332	3126610	3127551

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 94.74.

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.74	gold quality
hair follicle	UBERON:0002073	76.55	gold quality
decidua	UBERON:0002450	56.55	gold quality
quadriceps femoris	UBERON:0001377	50.36	gold quality
vastus lateralis	UBERON:0001379	50.09	gold quality
palpebral conjunctiva	UBERON:0001812	44.31	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
trachea	UBERON:0003126	43.09	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
epithelium of nasopharynx	UBERON:0001951	41.89	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
oviduct epithelium	UBERON:0004804	41.19	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
ventricular zone	UBERON:0003053	40.67	silver quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
oocyte	CL:0000023	39.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• OR17-209 fails to bind to the pig odorant-binding protein, while OR17-201 exhibits specific saturable binding (PMID:12379593)
• OR1G1 recognizes a group of odorants that share both 3D structural and perceptual qualities. (PMID:18603653)
• Or1g1 is examined within a model for recognition of broadly tuned olfactory receptors. (PMID:22926438)

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 1G1 — P47890 (reviewed: P47890)

Alternative names: Olfactory receptor 17-209, Olfactory receptor 1G2, Olfactory receptor OR17-8

All UniProt accessions (2): P47890, A0A126GW57

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_003546* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence conflict 2, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P47890-F1	84.11	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 33 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_UP, GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY

GO Biological Process (6): signal transduction (GO:0007165), adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of chemical stimulus (GO:0007606), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (4): olfactory receptor activity (GO:0004984), G protein-coupled olfactory receptor activity (GO:0038022), G protein-coupled receptor activity (GO:0004930), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	2
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1
adenylate cyclase activator activity	1
signal transduction	1
sensory perception	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
detection of chemical stimulus involved in sensory perception of smell	1
olfactory receptor activity	1
G protein-coupled receptor signaling pathway	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

224 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1G1	OBP2B	Q9NPH6	553
OR1G1	OR52D1	Q9H346	474
OR1G1	TAS2R1	Q9NYW7	447
OR1G1	RTP1	P59025	443
OR1G1	RHO	P08100	394
OR1G1	MYLK2	Q9H1R3	374
OR1G1	TPK1	Q9H3S4	374
OR1G1	CNGA2	Q16280	366
OR1G1	SPAG6	O75602	366
OR1G1	RTP2	Q5QGT7	363
OR1G1	GATB	O75879	358
OR1G1	PPEF2	O14830	346
OR1G1	MORC1	Q86VD1	328
OR1G1	PRKAG3	Q9UGI9	321
OR1G1	TAS2R14	Q9NYV8	311

IntAct

0 interactions, top by confidence:

BioGRID (1): OR1G1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6ND48, B2RN74, O60412, O76099, O76100, O95047, P23271, P23272, P34982, P37069, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGE0, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGS2, Q8NGW1, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07, Q8NH80, Q8NHA4, Q8NHC7, Q8VEY3, Q8VFC9, Q8WZA6

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

397 predictions. Top by Δscore:

Variant	Effect	Δscore
17:3126892:G:C	acceptor_gain	0.8200
17:3126896:G:C	acceptor_gain	0.8100
17:3126898:G:GC	acceptor_gain	0.8100
17:3126895:CG:C	acceptor_gain	0.7800
17:3126896:G:GC	acceptor_gain	0.7700
17:3126910:C:CT	acceptor_gain	0.7400
17:3127432:TGCC:T	donor_gain	0.7300
17:3126911:A:T	acceptor_gain	0.7200
17:3126891:C:CT	acceptor_gain	0.7100
17:3126898:G:C	acceptor_gain	0.7100
17:3127434:C:CT	donor_gain	0.7100
17:3126740:T:TA	donor_gain	0.7000
17:3126884:G:T	acceptor_gain	0.7000
17:3126770:C:CC	acceptor_gain	0.6900
17:3126905:A:C	acceptor_gain	0.6900
17:3127429:G:A	donor_gain	0.6900
17:3126680:C:CC	acceptor_gain	0.6800
17:3126792:T:TA	donor_gain	0.6800
17:3126878:A:C	acceptor_gain	0.6800
17:3127435:C:CT	donor_gain	0.6500
17:3126999:G:C	donor_gain	0.6400
17:3127249:CAA:C	donor_gain	0.6400
17:3126854:C:A	donor_gain	0.6200
17:3126998:A:AC	donor_gain	0.6200
17:3126767:GAA:G	acceptor_gain	0.6100
17:3126809:A:AC	donor_gain	0.6100
17:3126810:C:CC	donor_gain	0.6100
17:3126811:C:CC	donor_gain	0.6100
17:3126676:CAAA:C	acceptor_gain	0.6000
17:3126723:T:TA	donor_gain	0.5900

AlphaMissense

2063 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:3127048:G:C	F168L	0.739
17:3127048:G:T	F168L	0.739
17:3127050:A:G	F168L	0.739
17:3127021:G:C	F177L	0.677
17:3127021:G:T	F177L	0.677
17:3127023:A:G	F177L	0.677
17:3127459:G:C	F31L	0.648
17:3127459:G:T	F31L	0.648
17:3127461:A:G	F31L	0.648
17:3126799:G:C	F251L	0.636
17:3126799:G:T	F251L	0.636
17:3126801:A:G	F251L	0.636
17:3126838:A:C	F238L	0.624
17:3126838:A:T	F238L	0.624
17:3126840:A:G	F238L	0.624
17:3127213:G:C	F113L	0.583
17:3127213:G:T	F113L	0.583
17:3127215:A:G	F113L	0.583
17:3127018:G:C	F178L	0.578
17:3127018:G:T	F178L	0.578
17:3127020:A:G	F178L	0.578
17:3126688:A:C	F288L	0.577
17:3126688:A:T	F288L	0.577
17:3126690:A:G	F288L	0.577
17:3126796:A:C	F252L	0.571
17:3126796:A:T	F252L	0.571
17:3126798:A:G	F252L	0.571

dbSNP variants (sampled 300 via entrez): RS1000043329 (17:3129234 C>A), RS1000617243 (17:3127726 A>G), RS1001622772 (17:3126495 A>G,T), RS1002474205 (17:3126771 T>C), RS1004465806 (17:3128553 A>G), RS1004517171 (17:3128375 C>T), RS1005212867 (17:3126227 T>C), RS1006220517 (17:3127457 A>C), RS1008635592 (17:3129434 G>A), RS1008698078 (17:3128878 C>T), RS1009697196 (17:3127710 C>G), RS1009750606 (17:3127443 C>T), RS1010704990 (17:3126381 C>A), RS1010819591 (17:3126746 T>A), RS1012179333 (17:3128621 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001894_2	Endometriosis	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
geraniol	increases reaction, increases secretion	1
denatonium	decreases reaction, increases secretion	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Rotenone	decreases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.