OR1M1

Summary

OR1M1 (olfactory receptor family 1 subfamily M member 1, HGNC:8220) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 1M1 (Q8NGA1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 125963 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_001004456

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8220
Approved symbol	OR1M1
Name	olfactory receptor family 1 subfamily M member 1
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OR19-6
Ensembl gene	ENSG00000170929
Ensembl biotype	protein_coding
Entrez	125963

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000429566, ENST00000641627

RefSeq mRNA: 1 — MANE Select: NM_001004456 NM_001004456

CCDS: CCDS32896

Canonical transcript exons

ENST00000641627 — 2 exons

Exon	Start	End
ENSE00003811809	9093232	9095669
ENSE00003812953	9087061	9087157

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 52.64.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	52.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.11	gold quality
right uterine tube	UBERON:0001302	41.05	silver quality
apex of heart	UBERON:0002098	39.50	silver quality
skeletal muscle tissue	UBERON:0001134	39.46	gold quality
stromal cell of endometrium	CL:0002255	38.91	gold quality
ganglionic eminence	UBERON:0004023	38.86	gold quality
blood	UBERON:0000178	38.62	gold quality
lower esophagus mucosa	UBERON:0035834	38.46	gold quality
bone marrow cell	CL:0002092	38.31	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
muscle tissue	UBERON:0002385	37.02	gold quality
duodenum	UBERON:0002114	36.67	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
monocyte	CL:0000576	36.38	gold quality
liver	UBERON:0002107	36.18	gold quality
leukocyte	CL:0000738	36.12	gold quality
calcaneal tendon	UBERON:0003701	35.87	gold quality
granulocyte	CL:0000094	35.77	gold quality
endometrium	UBERON:0001295	35.55	gold quality
bone marrow	UBERON:0002371	35.03	gold quality
placenta	UBERON:0001987	34.98	silver quality
cerebellum	UBERON:0002037	34.09	gold quality
cerebellar cortex	UBERON:0002129	33.94	gold quality
right lung	UBERON:0002167	33.91	gold quality
cerebellar hemisphere	UBERON:0002245	33.72	gold quality
descending thoracic aorta	UBERON:0002345	33.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	32.84	gold quality
lymph node	UBERON:0000029	32.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28
E-MTAB-5061	no	2.02

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or1m1	ENSMUSG00000054141
rattus_norvegicus	Or1m1	ENSRNOG00000006428

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 1M1 — Q8NGA1 (reviewed: Q8NGA1)

Alternative names: Olfactory receptor 19-6, Olfactory receptor OR19-5

All UniProt accessions (1): Q8NGA1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004456* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGA1-F1	89.33	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of chemical stimulus (GO:0007606), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1M1	MAGEB5	Q9BZ81	507
OR1M1	DNHD1	Q96M86	474
OR1M1	MBD3L1	Q8WWY6	468
OR1M1	SDE2	Q6IQ49	455
OR1M1	TARBP1	Q13395	414
OR1M1	SPCS1	Q9Y6A9	401
OR1M1	EVI2B	P34910	389
OR1M1	TUBA4B	Q9H853	370
OR1M1	DYNLL2	Q96FJ2	366
OR1M1	EBLN2	Q6P2I7	348
OR1M1	ATP13A3	Q9H7F0	342
OR1M1	P4HTM	Q9NXG6	329
OR1M1	DNAH10	Q8IVF4	326
OR1M1	MCM9	Q9NXL9	324
OR1M1	CROCC2	H7BZ55	321

IntAct

7 interactions, top by confidence:

A	B	Type	Score
E2F8	OR1M1	psi-mi:“MI:0915”(physical association)	0.400
ANXA5	OR1M1	psi-mi:“MI:0915”(physical association)	0.400
OR1M1	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR1M1	psi-mi:“MI:0915”(physical association)	0.370
OR1M1	NBAS	psi-mi:“MI:0914”(association)	0.350
ZCCHC9	S100A10	psi-mi:“MI:0914”(association)	0.350

BioGRID (25): OSBPL8 (Affinity Capture-MS), NBAS (Affinity Capture-MS), PKMYT1 (Affinity Capture-MS), EDEM1 (Affinity Capture-MS), LRP10 (Affinity Capture-MS), C1orf43 (Affinity Capture-MS), OR1M1 (Affinity Capture-MS), FNDC3B (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FZD2 (Affinity Capture-MS), ANKLE2 (Affinity Capture-MS), TYW1 (Affinity Capture-MS), UFL1 (Affinity Capture-MS), GOLGA2 (Affinity Capture-MS), ATF6B (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P58180, Q13606, Q15615, Q60878, Q60881, Q60888, Q60893, Q6IEV9, Q6IEY1, Q6IF82, Q6UXT6, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGA1, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD3, Q8NGD4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

234 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9093565:T:TA	acceptor_gain	0.7900
19:9093569:ATCGT:A	acceptor_gain	0.7200
19:9094000:T:TA	acceptor_gain	0.7200
19:9094055:G:GT	donor_gain	0.7000
19:9093985:G:GA	donor_gain	0.6800
19:9093999:AT:A	acceptor_gain	0.6600
19:9094001:G:A	acceptor_gain	0.6500
19:9093987:T:TA	donor_gain	0.6300
19:9093863:A:AG	donor_gain	0.6200
19:9093999:ATG:A	acceptor_gain	0.6200
19:9094035:C:A	acceptor_gain	0.6100
19:9094077:ACAC:A	donor_gain	0.6100
19:9093856:G:T	donor_gain	0.5900
19:9094056:A:T	donor_gain	0.5900
19:9094000:T:G	acceptor_gain	0.5700
19:9094072:G:A	donor_gain	0.5500
19:9093828:A:G	donor_gain	0.5400
19:9094201:G:GT	donor_gain	0.5400
19:9094202:A:T	donor_gain	0.5300
19:9093855:G:GT	donor_gain	0.5200
19:9093927:T:TA	donor_gain	0.5200
19:9093950:A:T	donor_gain	0.5100
19:9093999:ATGG:A	acceptor_gain	0.5000
19:9094068:C:CA	donor_gain	0.5000
19:9093981:C:A	donor_gain	0.4900
19:9094074:T:G	donor_gain	0.4800
19:9093569:ATC:A	acceptor_gain	0.4600
19:9093864:T:G	donor_gain	0.4600
19:9094116:GCTT:G	acceptor_gain	0.4600
19:9094194:G:GT	donor_gain	0.4600

AlphaMissense

2053 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9093278:T:C	F12L	0.894
19:9093280:C:A	F12L	0.894
19:9093280:C:G	F12L	0.894
19:9093746:T:C	F168L	0.892
19:9093748:C:A	F168L	0.892
19:9093748:C:G	F168L	0.892
19:9093578:A:C	S112R	0.838
19:9093580:C:A	S112R	0.838
19:9093580:C:G	S112R	0.838
19:9094115:A:C	S291R	0.830
19:9094117:C:A	S291R	0.830
19:9094117:C:G	S291R	0.830
19:9093611:T:C	F123L	0.828
19:9093613:C:A	F123L	0.828
19:9093613:C:G	F123L	0.828
19:9093776:T:C	F178L	0.808
19:9093778:C:A	F178L	0.808
19:9093778:C:G	F178L	0.808
19:9094086:T:A	V281D	0.801
19:9093609:G:C	R122P	0.796
19:9093598:G:A	M118I	0.778
19:9093598:G:C	M118I	0.778
19:9093598:G:T	M118I	0.778
19:9093335:T:C	F31L	0.774
19:9093337:C:A	F31L	0.774
19:9093337:C:G	F31L	0.774
19:9093995:T:C	F251L	0.774
19:9093997:C:A	F251L	0.774
19:9093997:C:G	F251L	0.774
19:9093458:T:C	C72R	0.771

dbSNP variants (sampled 300 via entrez): RS1000302336 (19:9086920 G>A), RS1000591734 (19:9094770 A>G), RS1001267078 (19:9086182 A>G), RS1001287160 (19:9086419 G>A), RS1001362428 (19:9086642 C>T), RS1001605612 (19:9091264 G>A,C), RS1001616351 (19:9096156 A>G,T), RS1001697131 (19:9085850 C>T), RS1001823813 (19:9091083 C>T), RS1002260327 (19:9087350 T>C), RS1002301401 (19:9087476 A>G), RS1002866750 (19:9090957 G>A,T), RS1003229747 (19:9092406 C>T), RS1003299298 (19:9095341 G>A), RS1003299731 (19:9088555 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003542_87	Night sleep phenotypes	5.000000e-06
GCST007798_109	Asthma	1.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Catechin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.