OR1N1

Summary

OR1N1 (olfactory receptor family 1 subfamily N member 1, HGNC:8221) is a protein-coding gene on chromosome 9q33.2, encoding Olfactory receptor 1N1 (Q8NGS0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 138883 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_012363

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8221
Approved symbol	OR1N1
Name	olfactory receptor family 1 subfamily N member 1
Location	9q33.2
Locus type	gene with protein product
Status	Approved
Aliases	OR1-26
Ensembl gene	ENSG00000171505
Ensembl biotype	protein_coding
Entrez	138883

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000304880

RefSeq mRNA: 1 — MANE Select: NM_012363 NM_012363

CCDS: CCDS6844

Canonical transcript exons

ENST00000304880 — 1 exons

Exon	Start	End
ENSE00001167199	122526358	122527293

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 80.01.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.01	silver quality
bone marrow cell	CL:0002092	42.75	gold quality
colonic epithelium	UBERON:0000397	41.98	gold quality
stromal cell of endometrium	CL:0002255	40.17	gold quality
ganglionic eminence	UBERON:0004023	37.54	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.14	gold quality
bone marrow	UBERON:0002371	35.11	gold quality
endometrium	UBERON:0001295	34.77	silver quality
primary visual cortex	UBERON:0002436	34.25	gold quality
urinary bladder	UBERON:0001255	33.54	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
liver	UBERON:0002107	32.38	gold quality
tonsil	UBERON:0002372	32.04	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
prefrontal cortex	UBERON:0000451	29.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	29.37	gold quality
lymph node	UBERON:0000029	28.98	gold quality
duodenum	UBERON:0002114	28.14	gold quality
superior frontal gyrus	UBERON:0002661	27.41	gold quality
blood	UBERON:0000178	26.86	gold quality
leukocyte	CL:0000738	26.63	gold quality
monocyte	CL:0000576	26.54	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
frontal cortex	UBERON:0001870	26.33	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
cortex of kidney	UBERON:0001225	25.97	gold quality
muscle of leg	UBERON:0001383	25.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or1n1b	ENSMUSG00000075382
mus_musculus	Or1n1	ENSMUSG00000075383
rattus_norvegicus	Or1n1	ENSRNOG00000078732
rattus_norvegicus	Or1n1b	ENSRNOG00000084314

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 1N1 — Q8NGS0 (reviewed: Q8NGS0)

Alternative names: Olfactory receptor 1-26, Olfactory receptor 1N3, Olfactory receptor OR9-22

All UniProt accessions (2): Q8NGS0, A0A126GW31

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_036495* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGS0-F1	89.25	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, WP_GPCRS_OTHER, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

74 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1N1	KRTAP19-8	Q3LI54	666
OR1N1	KRTAP5-7	Q6L8G8	575
OR1N1	KRTAP5-11	Q6L8G4	505
OR1N1	KRTAP5-5	Q701N2	480
OR1N1	FAM114A2	Q9NRY5	476
OR1N1	NMUR2	Q9GZQ4	322
OR1N1	KDM3B	Q7LBC6	292
OR1N1	TAS2R42	Q7RTR8	287
OR1N1	LLPH	Q9BRT6	269
OR1N1	DDX59	Q5T1V6	248
OR1N1	TAS2R16	Q9NYV7	227
OR1N1	N4BP2	Q86UW6	220
OR1N1	CATSPER2	Q96P56	196
OR1N1	INSL5	Q9Y5Q6	185
OR1N1	CAMSAP2	Q08AD1	181

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR1N1	PLBD1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): PLBD1 (Affinity Capture-MS)

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, O43749, O60412, O76000, O76001, O76002, O95006, O95047, O95371, O95918, P0C626, P23266, P23269, P23272, P23273, P23274, P23275, P30953, P30955, P34982, P34984, P34986, P58173, P58181, P59922, P70526, Q13606, Q13607, Q15617, Q15619, Q5TZ20, Q60879, Q60890, Q6IEU7, Q6IF42, Q6UXT6, Q8N628, Q8NGA1, Q8NGC9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

293 predictions. Top by Δscore:

Variant	Effect	Δscore
9:122527202:CA:C	donor_gain	0.8400
9:122527086:CCA:C	acceptor_gain	0.7800
9:122527201:A:AC	donor_gain	0.7700
9:122527202:C:CC	donor_gain	0.7700
9:122526543:CA:C	acceptor_gain	0.7500
9:122527202:CACA:C	donor_gain	0.7500
9:122526542:CCA:C	acceptor_gain	0.7000
9:122527068:C:CC	acceptor_gain	0.7000
9:122527200:TAC:T	donor_gain	0.7000
9:122527201:ACA:A	donor_gain	0.7000
9:122527202:CAC:C	donor_gain	0.7000
9:122527198:CATA:C	donor_loss	0.6900
9:122527199:ATAC:A	donor_loss	0.6900
9:122527200:TACAC:T	donor_loss	0.6900
9:122527201:A:C	donor_loss	0.6900
9:122527202:C:CA	donor_loss	0.6900
9:122527197:ACAT:A	donor_loss	0.6800
9:122527202:CACAG:C	donor_gain	0.6600
9:122526544:A:C	acceptor_gain	0.6500
9:122527196:TAC:T	donor_loss	0.6500
9:122526543:C:T	acceptor_gain	0.6200
9:122527194:GATAC:G	donor_loss	0.6200
9:122527195:ATACA:A	donor_loss	0.6200
9:122527213:T:TA	donor_gain	0.6200
9:122526428:C:CC	acceptor_gain	0.6100
9:122526595:G:A	donor_gain	0.5900
9:122527087:CA:C	acceptor_gain	0.5900
9:122526605:C:CT	donor_gain	0.5700
9:122526978:C:CT	acceptor_gain	0.5700
9:122526691:T:TA	donor_gain	0.5600

AlphaMissense

2053 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:122526796:G:C	F166L	0.929
9:122526796:G:T	F166L	0.929
9:122526798:A:G	F166L	0.929
9:122527264:A:C	F10L	0.914
9:122527264:A:T	F10L	0.914
9:122527266:A:G	F10L	0.914
9:122526547:G:C	F249L	0.909
9:122526547:G:T	F249L	0.909
9:122526549:A:G	F249L	0.909
9:122526766:G:C	F176L	0.900
9:122526766:G:T	F176L	0.900
9:122526768:A:G	F176L	0.900
9:122526427:G:C	S289R	0.888
9:122526427:G:T	S289R	0.888
9:122526429:T:G	S289R	0.888
9:122526769:A:C	F175L	0.862
9:122526769:A:T	F175L	0.862
9:122526771:A:G	F175L	0.862
9:122526749:A:T	V182D	0.861
9:122526764:C:G	C177S	0.852
9:122526765:A:T	C177S	0.852
9:122526964:G:C	S110R	0.849
9:122526964:G:T	S110R	0.849
9:122526966:T:G	S110R	0.849
9:122526442:G:C	N284K	0.832
9:122526442:G:T	N284K	0.832
9:122527010:C:G	C95S	0.832
9:122527011:A:T	C95S	0.832
9:122527207:G:C	F29L	0.823
9:122527207:G:T	F29L	0.823

dbSNP variants (sampled 300 via entrez): RS1000117179 (9:122529292 G>A,C), RS1001177590 (9:122526046 G>T), RS1002191338 (9:122528200 G>A), RS1003666226 (9:122527733 T>A), RS1004917138 (9:122528763 T>A), RS1005678308 (9:122526782 T>C), RS1005741937 (9:122528780 A>C,G,T), RS1006987555 (9:122528454 C>T), RS1007047381 (9:122525869 C>T), RS1009097077 (9:122526249 A>G), RS1009930782 (9:122529052 G>A), RS1010150011 (9:122528850 G>A), RS1010827618 (9:122526321 G>A,T), RS1011151552 (9:122527768 G>T), RS1011472482 (9:122526455 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Atrazine	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.