OR1N2

Summary

OR1N2 (olfactory receptor family 1 subfamily N member 2, HGNC:15111) is a protein-coding gene on chromosome 9q33.2, encoding Olfactory receptor 1N2 (Q8NGR9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 138882 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total — 1 pathogenic
• MANE Select transcript: NM_001004457

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15111
Approved symbol	OR1N2
Name	olfactory receptor family 1 subfamily N member 2
Location	9q33.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000171501
Ensembl biotype	protein_coding
Entrez	138882

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000373688

RefSeq mRNA: 1 — MANE Select: NM_001004457 NM_001004457

CCDS: CCDS35123

Canonical transcript exons

ENST00000373688 — 1 exons

Exon	Start	End
ENSE00001461233	122553112	122554214

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 84.35.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.35	gold quality
colonic epithelium	UBERON:0000397	41.39	gold quality
bone marrow cell	CL:0002092	38.64	gold quality
granulocyte	CL:0000094	37.99	gold quality
apex of heart	UBERON:0002098	37.40	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
sural nerve	UBERON:0015488	36.21	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
calcaneal tendon	UBERON:0003701	34.38	gold quality
bone marrow	UBERON:0002371	34.23	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
endometrium	UBERON:0001295	32.62	gold quality
tonsil	UBERON:0002372	32.32	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	30.85	gold quality
corpus callosum	UBERON:0002336	30.13	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
liver	UBERON:0002107	28.30	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.87	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.95	gold quality
leukocyte	CL:0000738	26.87	gold quality
blood	UBERON:0000178	26.86	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
monocyte	CL:0000576	26.14	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.12

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or1n2	ENSMUSG00000055088
rattus_norvegicus	Or1n2	ENSRNOG00000007954

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 1N2 — Q8NGR9 (reviewed: Q8NGR9)

Alternative names: Olfactory receptor OR9-23

All UniProt accessions (1): Q8NGR9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004457* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGR9-F1	88.42	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 100–182

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, GAO_LARGE_INTESTINE_ADULT_CE_OLFM4HIGH_STEM_CELL, REACTOME_OLFACTORY_SIGNALING_PATHWAY, ZSCAN4_TARGET_GENES, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

144 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1N2	RFPL3	O75679	505
OR1N2	FHAD1	B1AJZ9	448
OR1N2	TRIM16L	Q309B1	447
OR1N2	ADGRF3	Q8IZF5	435
OR1N2	LRRC38	Q5VT99	434
OR1N2	HEPHL1	Q6MZM0	417
OR1N2	UMODL1	Q5DID0	396
OR1N2	MVB12B	Q9H7P6	393
OR1N2	THSD7B	Q9C0I4	379
OR1N2	DENND3	A2RUS2	377
OR1N2	INTS9	Q9NV88	370
OR1N2	CAMSAP2	Q08AD1	356
OR1N2	TAAR5	O14804	355
OR1N2	SYT10	Q6XYQ8	349
OR1N2	TREML4	Q6UXN2	339

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A3B3IT45, A6NGY5, A6NMU1, A6NND4, O43749, O60431, O88628, P0C626, P0C646, P0C7T3, P0DN81, P23266, P23272, P23273, P23274, P30953, P30955, P58181, P70526, Q13607, Q6IF63, Q6IFG1, Q6W049, Q8NG95, Q8NG99, Q8NGA0, Q8NGA1, Q8NGC4, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1711101	GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3	Pathogenic

SpliceAI

54 predictions. Top by Δscore:

Variant	Effect	Δscore
9:122553961:G:GA	donor_gain	0.6300
9:122553660:T:A	donor_gain	0.5900
9:122553960:T:TA	donor_gain	0.5500
9:122553396:T:G	donor_gain	0.4000
9:122553960:T:TG	donor_loss	0.3400
9:122553961:G:GG	donor_loss	0.3400
9:122553985:TATGG:T	donor_loss	0.3400
9:122553986:ATGG:A	donor_loss	0.3400
9:122553987:TGGGT:T	donor_loss	0.3400
9:122553988:GGGT:G	donor_loss	0.3400
9:122553989:GGT:G	donor_loss	0.3400
9:122553991:T:G	donor_loss	0.3400
9:122553992:GTGTA:G	donor_loss	0.3400
9:122553993:TG:T	donor_loss	0.3400
9:122553659:G:A	donor_gain	0.3300
9:122553994:G:C	donor_loss	0.3300
9:122554031:G:T	donor_gain	0.3200
9:122554062:T:G	donor_gain	0.3200
9:122553319:C:T	donor_gain	0.3100
9:122553990:G:GG	donor_gain	0.3100
9:122554032:A:T	donor_gain	0.3100
9:122553926:A:T	donor_gain	0.3000
9:122553400:C:CG	donor_gain	0.2900
9:122553925:G:GT	donor_gain	0.2900
9:122553957:C:CA	donor_gain	0.2900
9:122553959:G:GT	donor_loss	0.2900
9:122553988:GG:G	donor_gain	0.2800
9:122553989:GG:G	donor_gain	0.2800
9:122553943:T:TA	donor_gain	0.2700
9:122553956:AC:A	donor_gain	0.2700

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:122553574:G:A	M135I	0.939
9:122553574:G:C	M135I	0.939
9:122553574:G:T	M135I	0.939
9:122553722:T:C	F185L	0.925
9:122553724:C:A	F185L	0.925
9:122553724:C:G	F185L	0.925
9:122553254:T:C	F29L	0.924
9:122553256:C:A	F29L	0.924
9:122553256:C:G	F29L	0.924
9:122554091:A:C	S308R	0.907
9:122554093:C:A	S308R	0.907
9:122554093:C:G	S308R	0.907
9:122553585:G:C	R139P	0.903
9:122553749:T:C	F194L	0.884
9:122553751:C:A	F194L	0.884
9:122553751:C:G	F194L	0.884
9:122553434:T:C	C89R	0.875
9:122553971:T:C	F268L	0.872
9:122553973:C:A	F268L	0.872
9:122553973:C:G	F268L	0.872
9:122553576:C:A	A136E	0.870
9:122553582:A:C	D138A	0.856
9:122553255:T:C	F29S	0.850
9:122553882:T:C	I238T	0.849
9:122553954:T:C	L262P	0.849
9:122553582:A:T	D138V	0.844
9:122553346:C:A	N59K	0.841
9:122553346:C:G	N59K	0.841
9:122554099:G:C	R310S	0.841
9:122554099:G:T	R310S	0.841

dbSNP variants (sampled 300 via entrez): RS1000571140 (9:122552462 A>C), RS1002929690 (9:122552392 C>T), RS1003266973 (9:122551190 A>G), RS1005536607 (9:122551134 A>C,G), RS1006372151 (9:122551702 G>C), RS1007222699 (9:122554587 T>A), RS1007946959 (9:122552601 C>T), RS1007997869 (9:122552355 C>T), RS1008987454 (9:122553745 T>C), RS1012087429 (9:122552943 C>A), RS1013012185 (9:122552755 T>A), RS1013809873 (9:122551397 C>A,T), RS1014018472 (9:122554241 A>G), RS1015345854 (9:122554212 T>C), RS1016411438 (9:122551894 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Atrazine	increases expression	1
Aflatoxin B1	decreases methylation	1
Sodium Selenite	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.