OR1R1

Summary

OR1R1 (olfactory receptor family 1 subfamily R member 1, HGNC:8226) is a protein-coding gene on chromosome 17p13.3, encoding Olfactory receptor 1R1 (A0A286YEU6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 9596 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001396056

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8226
Approved symbol	OR1R1
Name	olfactory receptor family 1 subfamily R member 1
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	OR17-1
Ensembl gene	ENSG00000180042
Ensembl biotype	protein_coding
Entrez	9596

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000572493

RefSeq mRNA: 1 — MANE Select: NM_001396056 NM_001396056

CCDS: CCDS92226

Canonical transcript exons

ENST00000572493 — 1 exons

Exon	Start	End
ENSE00002663229	3385930	3386874

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 83.50.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.50	gold quality
myocardium	UBERON:0002349	82.40	gold quality
tendon of biceps brachii	UBERON:0008188	79.70	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.62	gold quality
heart right ventricle	UBERON:0002080	73.01	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	69.47	gold quality
vastus lateralis	UBERON:0001379	69.42	gold quality
quadriceps femoris	UBERON:0001377	69.20	gold quality
biceps brachii	UBERON:0001507	68.00	gold quality
parotid gland	UBERON:0001831	67.55	gold quality
medial globus pallidus	UBERON:0002477	64.40	gold quality
nasal cavity epithelium	UBERON:0005384	61.98	gold quality
globus pallidus	UBERON:0001875	61.79	gold quality
jejunal mucosa	UBERON:0000399	59.96	gold quality
mucosa of sigmoid colon	UBERON:0004993	58.97	gold quality
superficial temporal artery	UBERON:0001614	58.79	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	58.54	gold quality
vena cava	UBERON:0004087	57.78	gold quality
colonic mucosa	UBERON:0000317	57.23	gold quality
lateral globus pallidus	UBERON:0002476	57.11	gold quality
decidua	UBERON:0002450	56.94	gold quality
lateral nuclear group of thalamus	UBERON:0002736	56.45	gold quality
buccal mucosa cell	CL:0002336	56.13	gold quality
germinal epithelium of ovary	UBERON:0001304	55.69	gold quality
gingiva	UBERON:0001828	55.36	gold quality
trabecular bone tissue	UBERON:0002483	55.14	gold quality
gingival epithelium	UBERON:0001949	55.02	gold quality
mucosa of paranasal sinus	UBERON:0005030	54.38	gold quality
seminal vesicle	UBERON:0000998	54.26	gold quality
cauda epididymis	UBERON:0004360	54.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or1r1	ENSMUSG00000049041
rattus_norvegicus	Or1r1	ENSRNOG00000019898

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 1R1 — A0A286YEU6 (reviewed: A0A286YEU6)

Alternative names: Olfactory receptor family 1 subfamily R member 1, Olfactory receptor family 1 subfamily R member 1 pseudogene

All UniProt accessions (1): A0A286YEU6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001382985* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for A0A286YEU6 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr17p13

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

6 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR1R1	HAUS3	Q68CZ6	73
OR1R1	OR52B4	Q8NGK2	0
OR1R1	OR2A12	Q8NGT7	0

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1982 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:3385963:T:C	F12L	0.846
17:3385965:C:A	F12L	0.846
17:3385965:C:G	F12L	0.846
17:3386128:A:C	S67R	0.831
17:3386130:C:A	S67R	0.831
17:3386130:C:G	S67R	0.831
17:3386146:T:C	F73L	0.815
17:3386148:T:A	F73L	0.815
17:3386148:T:G	F73L	0.815
17:3386458:T:C	F177L	0.815
17:3386460:C:A	F177L	0.815
17:3386460:C:G	F177L	0.815
17:3386461:T:C	F178L	0.791
17:3386463:T:A	F178L	0.791
17:3386463:T:G	F178L	0.791
17:3386800:A:C	S291R	0.780
17:3386802:C:A	S291R	0.780
17:3386802:C:G	S291R	0.780
17:3386680:T:C	F251L	0.779
17:3386682:C:A	F251L	0.779
17:3386682:C:G	F251L	0.779
17:3386239:T:C	F104L	0.775
17:3386241:C:A	F104L	0.775
17:3386241:C:G	F104L	0.775
17:3386683:T:C	F252L	0.757
17:3386685:T:A	F252L	0.757
17:3386685:T:G	F252L	0.757
17:3386384:C:A	T152K	0.756
17:3386221:T:C	F98L	0.751
17:3386223:T:A	F98L	0.751

dbSNP variants (sampled 300 via entrez): RS1000228057 (17:3386339 C>T), RS1000712135 (17:3387298 A>C,G), RS1001902880 (17:3385128 A>ACTCCG), RS1002758257 (17:3385080 G>A), RS1005463586 (17:3384168 T>A,C,G), RS1005756877 (17:3386819 T>C), RS1006717040 (17:3385475 G>C), RS1007721481 (17:3384299 G>A), RS1008706620 (17:3387266 T>G), RS1009049326 (17:3386881 A>G,T), RS1009269901 (17:3387253 C>T), RS1009720013 (17:3384609 A>G), RS1010282928 (17:3386327 G>A), RS1010310439 (17:3385911 C>T), RS1010687811 (17:3386183 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.