OR2A14

Summary

OR2A14 (olfactory receptor family 2 subfamily A member 14, HGNC:15084) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 2A14 (Q96R47). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 135941 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001001659

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15084
Approved symbol	OR2A14
Name	olfactory receptor family 2 subfamily A member 14
Location	7q35
Locus type	gene with protein product
Status	Approved
Aliases	OST182
Ensembl gene	ENSG00000221938
Ensembl biotype	protein_coding
Entrez	135941

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000408899, ENST00000641068

RefSeq mRNA: 1 — MANE Select: NM_001001659 NM_001001659

CCDS: CCDS43672

Canonical transcript exons

ENST00000641068 — 2 exons

Exon	Start	End
ENSE00003811934	144129079	144131188
ENSE00003813114	144123176	144123264

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 89.99.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.99	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.46	gold quality
bone marrow cell	CL:0002092	45.00	gold quality
colonic epithelium	UBERON:0000397	43.13	gold quality
sural nerve	UBERON:0015488	41.86	gold quality
lower esophagus mucosa	UBERON:0035834	40.89	silver quality
tonsil	UBERON:0002372	40.23	gold quality
bone marrow	UBERON:0002371	39.63	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
mucosa of transverse colon	UBERON:0004991	36.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.53	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	34.98	gold quality
endometrium	UBERON:0001295	33.99	gold quality
mucosa of stomach	UBERON:0001199	33.77	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
endocervix	UBERON:0000458	32.91	silver quality
leukocyte	CL:0000738	31.91	gold quality
right lobe of thyroid gland	UBERON:0001119	31.88	gold quality
esophagus mucosa	UBERON:0002469	31.87	gold quality
monocyte	CL:0000576	31.79	gold quality
left ovary	UBERON:0002119	31.18	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	30.45	gold quality
upper lobe of left lung	UBERON:0008952	30.16	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
skin of abdomen	UBERON:0001416	29.57	gold quality
vagina	UBERON:0000996	29.52	gold quality
vermiform appendix	UBERON:0001154	29.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2a56	ENSMUSG00000073110
mus_musculus	Or2a14	ENSMUSG00000094200
mus_musculus	Or2a54	ENSMUSG00000094669
rattus_norvegicus	Or2a14	ENSRNOG00000087190

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 2A14 — Q96R47 (reviewed: Q96R47)

Alternative names: OST182, Olfactory receptor 2A6, Olfactory receptor OR7-12

All UniProt accessions (2): A0A126GVB0, Q96R47

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001659* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R47-F1	83.68	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, CHYLA_CBFA2T3_TARGETS_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, PAX3_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2A14	FAM162B	Q5T6X4	472
OR2A14	TMEM41A	Q96HV5	458
OR2A14	LCE5A	Q5TCM9	411
OR2A14	FER1L6	Q2WGJ9	393
OR2A14	ANKRD31	Q8N7Z5	378
OR2A14	GPR26	Q8NDV2	348
OR2A14	GPR42	O15529	348
OR2A14	RNF139	Q8WU17	342
OR2A14	NPBWR2	P48146	324
OR2A14	ACTL6B	O94805	321
OR2A14	OXER1	Q8TDS5	312
OR2A14	PLEKHA2	Q9HB19	310
OR2A14	SLC25A24	Q6NUK1	293
OR2A14	MAN1A2	O60476	288
OR2A14	TMEM41B	Q5BJD5	288

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

127 predictions. Top by Δscore:

Variant	Effect	Δscore
7:144129375:A:T	donor_gain	0.7900
7:144129303:ACCT:A	acceptor_gain	0.7500
7:144129374:G:GT	donor_gain	0.6000
7:144129665:AAGTT:A	acceptor_gain	0.6000
7:144129666:A:G	acceptor_gain	0.5700
7:144129306:T:TA	acceptor_gain	0.5500
7:144129303:ACCTG:A	acceptor_gain	0.5300
7:144129159:TCCAG:T	donor_loss	0.4800
7:144129160:CCAGG:C	donor_loss	0.4800
7:144129161:CAG:C	donor_loss	0.4800
7:144129162:AGG:A	donor_loss	0.4800
7:144129163:G:GT	donor_loss	0.4800
7:144129164:G:GA	donor_loss	0.4800
7:144129165:T:A	donor_loss	0.4800
7:144129304:C:G	acceptor_gain	0.4500
7:144129158:TTCCA:T	donor_loss	0.4200
7:144129168:G:C	donor_loss	0.4100
7:144129303:A:AG	acceptor_gain	0.4100
7:144129166:TGGT:T	donor_loss	0.4000
7:144129167:GGTC:G	donor_loss	0.4000
7:144129453:T:TA	acceptor_gain	0.3900
7:144129712:A:AG	acceptor_gain	0.3800
7:144129713:G:GG	acceptor_gain	0.3800
7:144129440:GAGT:G	acceptor_gain	0.3700
7:144129646:T:TA	acceptor_gain	0.3700
7:144129803:G:T	donor_gain	0.3600
7:144129166:T:A	donor_gain	0.3500
7:144129713:GCCT:G	acceptor_gain	0.3500
7:144129267:G:GG	donor_gain	0.3400
7:144129703:C:CT	acceptor_gain	0.3400

AlphaMissense

2029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:144129611:T:C	F167L	0.882
7:144129613:C:A	F167L	0.882
7:144129613:C:G	F167L	0.882
7:144129944:A:C	S278R	0.830
7:144129946:C:A	S278R	0.830
7:144129946:C:G	S278R	0.830
7:144129860:T:C	F250L	0.823
7:144129862:C:A	F250L	0.823
7:144129862:C:G	F250L	0.823
7:144129863:T:C	F251L	0.820
7:144129865:T:A	F251L	0.820
7:144129865:T:G	F251L	0.820
7:144129641:T:C	F177L	0.815
7:144129643:C:A	F177L	0.815
7:144129643:C:G	F177L	0.815
7:144129980:A:C	S290R	0.800
7:144129982:C:A	S290R	0.800
7:144129982:C:G	S290R	0.800
7:144129821:T:C	F237L	0.792
7:144129823:C:A	F237L	0.792
7:144129823:C:G	F237L	0.792
7:144129563:A:C	S151R	0.764
7:144129565:C:A	S151R	0.764
7:144129565:C:G	S151R	0.764
7:144129938:T:C	F276L	0.754
7:144129940:T:A	F276L	0.754
7:144129940:T:G	F276L	0.754
7:144129200:T:C	F30L	0.751
7:144129202:C:A	F30L	0.751
7:144129202:C:G	F30L	0.751

dbSNP variants (sampled 300 via entrez): RS1001117859 (7:144124160 T>C), RS1001188190 (7:144124449 C>A,T), RS1001205076 (7:144128300 T>C), RS1001664337 (7:144127997 A>C,G), RS1001765599 (7:144130706 G>T), RS1002267189 (7:144126258 A>C), RS1002598657 (7:144126687 T>C), RS1002856807 (7:144129336 A>C,G), RS1003316527 (7:144123248 C>A,G), RS1003441336 (7:144122919 G>A), RS1003465669 (7:144125833 A>T), RS1003880127 (7:144122599 T>G), RS1005018902 (7:144129966 A>T), RS1005364446 (7:144123210 G>A), RS1005607236 (7:144126239 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
arsenite	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.