OR2A25

Summary

OR2A25 (olfactory receptor family 2 subfamily A member 25, HGNC:19562) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 2A25 (A4D2G3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 392138 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001386096

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19562
Approved symbol	OR2A25
Name	olfactory receptor family 2 subfamily A member 25
Location	7q35
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000221933
Ensembl biotype	protein_coding
Entrez	392138

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000408898, ENST00000641441, ENST00000641663

RefSeq mRNA: 2 — MANE Select: NM_001386096 NM_001004488, NM_001386096

CCDS: CCDS43669

Canonical transcript exons

ENST00000641663 — 2 exons

Exon	Start	End
ENSE00003812228	144074216	144075870
ENSE00003814213	144069811	144069896

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 41.98.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	41.98	gold quality
apex of heart	UBERON:0002098	41.44	silver quality
sural nerve	UBERON:0015488	41.17	gold quality
cortical plate	UBERON:0005343	39.87	gold quality
stromal cell of endometrium	CL:0002255	39.36	gold quality
bone marrow cell	CL:0002092	38.50	gold quality
granulocyte	CL:0000094	37.39	gold quality
ganglionic eminence	UBERON:0004023	37.33	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
skeletal muscle tissue	UBERON:0001134	36.39	gold quality
tonsil	UBERON:0002372	36.14	gold quality
muscle tissue	UBERON:0002385	35.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.60	gold quality
leukocyte	CL:0000738	34.00	gold quality
monocyte	CL:0000576	33.99	gold quality
calcaneal tendon	UBERON:0003701	33.84	gold quality
liver	UBERON:0002107	33.21	gold quality
bone marrow	UBERON:0002371	32.94	gold quality
endometrium	UBERON:0001295	32.77	gold quality
right uterine tube	UBERON:0001302	32.63	gold quality
urinary bladder	UBERON:0001255	32.30	gold quality
vermiform appendix	UBERON:0001154	31.28	gold quality
thoracic mammary gland	UBERON:0005200	30.89	gold quality
endocervix	UBERON:0000458	30.55	gold quality
left ovary	UBERON:0002119	30.51	gold quality
prefrontal cortex	UBERON:0000451	29.69	gold quality
adenohypophysis	UBERON:0002196	29.21	gold quality
uterine cervix	UBERON:0000002	28.88	gold quality
lymph node	UBERON:0000029	28.81	gold quality
right lobe of liver	UBERON:0001114	28.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2a25	ENSMUSG00000045708
rattus_norvegicus	Or2a25	ENSRNOG00000005412

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 2A25 — A4D2G3 (reviewed: A4D2G3)

Alternative names: Olfactory receptor 2A27

All UniProt accessions (2): A4D2G3, A0A126GVV5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001004488, NP_001373025* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A4D2G3-F1	84.77	0.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

58 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2A25	LTAP1	Q9BWL3	252
OR2A25	RTP2	Q5QGT7	247
OR2A25	CPD	O75976	223
OR2A25	ADCY3	O60266	178
OR2A25	OR52N4	Q8NGI2	160
OR2A25	CNGA2	Q16280	158
OR2A25	GNG8	Q9UK08	115
OR2A25	GNAL	P38405	115
OR2A25	GNAS	Q5JWF2	115
OR2A25	HAUS3	Q68CZ6	73
OR2A25	ARRB2	P32121	56
OR2A25	ARRB1	P49407	56
OR2A25	OR2A7	Q96R45	55
OR2A25	PRKACA	P17612	42
OR2A25	GRK2	P25098	42
OR2A25	GRK3	P35626	42
OR2A25	PRKACB	P22694	42

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2A25	GHDC	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): GHDC (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

160 predictions. Top by Δscore:

Variant	Effect	Δscore
7:144074883:T:G	acceptor_gain	0.8300
7:144074410:ACCT:A	acceptor_gain	0.6700
7:144074882:AT:A	acceptor_gain	0.6500
7:144074882:ATGT:A	acceptor_gain	0.6300
7:144074800:ATGAG:A	donor_loss	0.6100
7:144074801:TGAG:T	donor_loss	0.6100
7:144074802:GAGGT:G	donor_loss	0.6100
7:144074803:AGG:A	donor_loss	0.6100
7:144074805:GTAAT:G	donor_loss	0.6100
7:144074882:A:AG	acceptor_gain	0.6100
7:144074806:T:A	donor_loss	0.6000
7:144074579:TCGG:T	donor_loss	0.5900
7:144074581:GGTA:G	donor_loss	0.5900
7:144074582:GT:G	donor_loss	0.5900
7:144074583:T:G	donor_loss	0.5900
7:144074802:GAG:G	donor_gain	0.5800
7:144074890:T:G	acceptor_gain	0.5700
7:144074896:A:AG	acceptor_gain	0.5500
7:144074897:G:GG	acceptor_gain	0.5500
7:144074582:G:GG	donor_gain	0.5400
7:144074577:GATCG:G	donor_gain	0.5200
7:144074584:ACGTG:A	donor_loss	0.5200
7:144074805:G:GG	donor_gain	0.5200
7:144074889:A:AG	acceptor_gain	0.5200
7:144074894:A:AG	acceptor_gain	0.5200
7:144074895:A:G	acceptor_gain	0.5200
7:144074883:T:TA	acceptor_gain	0.4900
7:144074885:T:TA	acceptor_gain	0.4800
7:144074411:C:G	acceptor_gain	0.4700
7:144074585:C:CC	donor_loss	0.4700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000053555 (7:144073764 A>G), RS1000202951 (7:144069769 A>T), RS1000788159 (7:144068394 T>A,C), RS1000852379 (7:144069729 G>GA), RS1000971728 (7:144074892 C>G,T), RS1001303980 (7:144068089 A>G), RS1002429418 (7:144075355 T>A,C), RS1002704877 (7:144069046 T>C), RS1003257063 (7:144070083 G>A,C,T), RS1004579207 (7:144067995 G>A), RS1004836626 (7:144072396 A>G), RS1005245376 (7:144069357 C>G), RS1005298172 (7:144070631 G>A), RS1005825985 (7:144070418 T>C), RS1006251596 (7:144067942 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	decreases expression	1
theaflavin-3,3’-digallate	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.