OR2A5

Summary

OR2A5 (olfactory receptor family 2 subfamily A member 5, HGNC:8232) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 2A5 (Q96R48). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 393046 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_012365

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8232
Approved symbol	OR2A5
Name	olfactory receptor family 2 subfamily A member 5
Location	7q35
Locus type	gene with protein product
Status	Approved
Aliases	OR7-138, OR7-141
Ensembl gene	ENSG00000221836
Ensembl biotype	protein_coding
Entrez	393046

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000641693, ENST00000641779

RefSeq mRNA: 1 — MANE Select: NM_012365 NM_012365

CCDS: CCDS43668

Canonical transcript exons

ENST00000641693 — 2 exons

Exon	Start	End
ENSE00003811978	144048948	144049133
ENSE00003813167	144050351	144058845

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 77.12.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.12	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.56	gold quality
sural nerve	UBERON:0015488	55.59	gold quality
mucosa of stomach	UBERON:0001199	50.73	gold quality
bone marrow cell	CL:0002092	48.00	gold quality
right adrenal gland cortex	UBERON:0035827	47.59	gold quality
rectum	UBERON:0001052	47.06	gold quality
muscle tissue	UBERON:0002385	46.68	gold quality
descending thoracic aorta	UBERON:0002345	46.66	gold quality
skeletal muscle tissue	UBERON:0001134	46.44	gold quality
smooth muscle tissue	UBERON:0001135	46.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	45.81	gold quality
gall bladder	UBERON:0002110	45.77	gold quality
fundus of stomach	UBERON:0001160	45.51	gold quality
tonsil	UBERON:0002372	45.46	silver quality
granulocyte	CL:0000094	45.40	silver quality
islet of Langerhans	UBERON:0000006	44.80	gold quality
bone marrow	UBERON:0002371	44.08	gold quality
tibial artery	UBERON:0007610	44.07	gold quality
popliteal artery	UBERON:0002250	44.02	gold quality
right adrenal gland	UBERON:0001233	43.78	gold quality
ganglionic eminence	UBERON:0004023	43.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	43.52	silver quality
leukocyte	CL:0000738	43.39	gold quality
thoracic aorta	UBERON:0001515	43.35	gold quality
ectocervix	UBERON:0012249	43.33	gold quality
right ovary	UBERON:0002118	43.31	gold quality
ascending aorta	UBERON:0001496	43.09	gold quality
pancreas	UBERON:0001264	43.04	gold quality
metanephros cortex	UBERON:0010533	42.86	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-124858	no	9.59
E-ANND-3	no	0.58

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2a5	ENSMUSG00000043119
rattus_norvegicus	Or2a5	ENSRNOG00000086140

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 2A5 — Q96R48 (reviewed: Q96R48)

Alternative names: Olfactory receptor 2A26, Olfactory receptor 2A8, Olfactory receptor 7-138/7-141

All UniProt accessions (2): Q96R48, A0A126GW49

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_036497* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 3, sequence conflict 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R48-F1	88.17	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, BOSCO_TH1_CYTOTOXIC_MODULE, WP_GPCRS_OTHER, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

66 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2A5	CNGA2	Q16280	428
OR2A5	GNG8	Q9UK08	408
OR2A5	GNG13	Q9P2W3	370
OR2A5	ANO2	Q9NQ90	365
OR2A5	GNAL	P38405	352
OR2A5	TEX15	Q9BXT5	348
OR2A5	GNGT2	O14610	310
OR2A5	BCL2L12	Q9HB09	300
OR2A5	ADCY3	O60266	283
OR2A5	SLC27A5	Q9Y2P5	270
OR2A5	MLH3	P49751	245
OR2A5	ADCY8	P40145	241
OR2A5	LHX2	P50458	221
OR2A5	ERMN	Q8TAM6	216
OR2A5	A0A140T9Z0	A0A140T9Z0	211

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

252 predictions. Top by Δscore:

Variant	Effect	Δscore
7:144050957:AAGTT:A	acceptor_gain	0.5900
7:144050816:G:GT	donor_gain	0.5800
7:144050816:G:T	donor_gain	0.5800
7:144051010:A:AG	acceptor_gain	0.5500
7:144051011:G:GG	acceptor_gain	0.5500
7:144051011:GT:G	acceptor_gain	0.5500
7:144050503:C:G	acceptor_gain	0.5200
7:144050750:ATGAT:A	donor_gain	0.5000
7:144051095:G:T	donor_gain	0.5000
7:144050958:A:G	acceptor_gain	0.4800
7:144051174:T:G	donor_gain	0.4800
7:144051334:G:GG	donor_gain	0.4800
7:144051095:G:GT	donor_gain	0.4700
7:144051039:T:TA	acceptor_gain	0.4600
7:144051236:A:AG	acceptor_gain	0.4600
7:144051237:G:GG	acceptor_gain	0.4600
7:144050958:AGTT:A	acceptor_gain	0.4400
7:144050959:GTTG:G	acceptor_gain	0.4400
7:144051004:T:A	acceptor_gain	0.4400
7:144051106:A:T	donor_gain	0.4400
7:144051140:ATGGT:A	acceptor_gain	0.4400
7:144051178:C:CG	donor_gain	0.4300
7:144050381:CGCAG:C	donor_loss	0.4100
7:144050383:CAG:C	donor_loss	0.4100
7:144050384:AGG:A	donor_loss	0.4100
7:144050385:GGT:G	donor_loss	0.4100
7:144050386:GTA:G	donor_loss	0.4100
7:144050387:T:A	donor_loss	0.4100
7:144050959:G:GG	acceptor_gain	0.4100
7:144051175:G:GG	donor_gain	0.4100

AlphaMissense

2024 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:144050903:T:C	F168L	0.899
7:144050905:C:A	F168L	0.899
7:144050905:C:G	F168L	0.899
7:144050432:T:C	F11L	0.889
7:144050434:C:A	F11L	0.889
7:144050434:C:G	F11L	0.889
7:144051272:A:C	S291R	0.883
7:144051274:C:A	S291R	0.883
7:144051274:C:G	S291R	0.883
7:144051152:T:C	F251L	0.859
7:144051154:C:A	F251L	0.859
7:144051154:C:G	F251L	0.859
7:144050447:T:C	F16L	0.838
7:144050449:T:A	F16L	0.838
7:144050449:T:G	F16L	0.838
7:144051161:A:C	S254R	0.835
7:144051163:C:A	S254R	0.835
7:144051163:C:G	S254R	0.835
7:144051155:T:C	F252L	0.830
7:144051157:T:A	F252L	0.830
7:144051157:T:G	F252L	0.830
7:144051113:T:C	F238L	0.810
7:144051115:C:A	F238L	0.810
7:144051115:C:G	F238L	0.810
7:144050933:T:C	F178L	0.804
7:144050935:C:A	F178L	0.804
7:144050935:C:G	F178L	0.804
7:144051063:T:C	I221T	0.793
7:144051236:A:C	S279R	0.789
7:144051238:C:A	S279R	0.789

dbSNP variants (sampled 300 via entrez): RS1000215162 (7:144057640 G>C), RS1000350780 (7:144047243 C>A,T), RS1000403145 (7:144047489 G>A,T), RS1000582473 (7:144052328 G>A,C), RS1000931880 (7:144052051 T>C), RS1000954895 (7:144056181 A>G), RS1001045805 (7:144058234 T>C), RS1001506716 (7:144051484 A>G), RS1001582034 (7:144048297 T>C), RS1001843945 (7:144050022 C>A,T), RS1001981720 (7:144047955 T>C), RS1002263689 (7:144058620 G>C), RS1002348287 (7:144056503 A>G), RS1002507869 (7:144052804 TA>T,TAA), RS1002640562 (7:144059225 ACAAGG>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001762_305	Obesity-related traits	7.000000e-06
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003940	physical activity
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.