OR2A7

Summary

OR2A7 (olfactory receptor family 2 subfamily A member 7, HGNC:8234) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 2A7 (Q96R45). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 401427 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• MANE Select transcript: NM_001005328

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8234
Approved symbol	OR2A7
Name	olfactory receptor family 2 subfamily A member 7
Location	7q35
Locus type	gene with protein product
Status	Approved
Aliases	HSDJ0798C17
Ensembl gene	ENSG00000243896
Ensembl biotype	protein_coding
Entrez	401427

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000493325, ENST00000641841

RefSeq mRNA: 1 — MANE Select: NM_001005328 NM_001005328

CCDS: CCDS55177

Canonical transcript exons

ENST00000641841 — 2 exons

Exon	Start	End
ENSE00003811730	144257663	144259632
ENSE00003813865	144264701	144264792

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 86.09.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.09	gold quality
duodenum	UBERON:0002114	81.48	gold quality
left lobe of thyroid gland	UBERON:0001120	81.45	gold quality
right uterine tube	UBERON:0001302	81.02	gold quality
thyroid gland	UBERON:0002046	80.72	gold quality
right lobe of thyroid gland	UBERON:0001119	80.57	gold quality
skin of abdomen	UBERON:0001416	80.07	gold quality
zone of skin	UBERON:0000014	80.01	gold quality
skin of leg	UBERON:0001511	79.95	gold quality
lower esophagus mucosa	UBERON:0035834	78.12	gold quality
metanephros cortex	UBERON:0010533	78.05	gold quality
body of pancreas	UBERON:0001150	75.31	gold quality
transverse colon	UBERON:0001157	75.30	gold quality
rectum	UBERON:0001052	75.29	gold quality
cortex of kidney	UBERON:0001225	75.04	gold quality
mucosa of transverse colon	UBERON:0004991	74.43	gold quality
minor salivary gland	UBERON:0001830	74.34	gold quality
thoracic mammary gland	UBERON:0005200	74.21	gold quality
esophagus mucosa	UBERON:0002469	73.71	gold quality
prostate gland	UBERON:0002367	73.60	gold quality
small intestine	UBERON:0002108	73.52	gold quality
saliva-secreting gland	UBERON:0001044	73.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.99	gold quality
pancreas	UBERON:0001264	72.89	gold quality
ectocervix	UBERON:0012249	72.72	gold quality
endometrium	UBERON:0001295	71.88	gold quality
adult mammalian kidney	UBERON:0000082	71.77	gold quality
kidney	UBERON:0002113	71.47	gold quality
body of stomach	UBERON:0001161	71.46	gold quality
right lung	UBERON:0002167	71.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Proliferation tests, ELISA and kinase array indicated that OR2A4/7 and CHS play important roles in the proliferation of HaCaT cells and keratinocytes. (PMID:27315375)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2a7	ENSMUSG00000043605
rattus_norvegicus	Or2a7	ENSRNOG00000065711

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 2A7 — Q96R45 (reviewed: Q96R45)

Alternative names: Olfactory receptor OR7-18

All UniProt accessions (2): Q96R45, A0A126GWD8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005328* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R45-F1	79.15	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MYC_UP.V1_DN, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

304 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2A7	TMEM128	Q5BJH2	479
OR2A7	ZSCAN5B	A6NJL1	419
OR2A7	TMEM179	Q6ZVK1	397
OR2A7	TRIM58	Q8NG06	370
OR2A7	RTP2	Q5QGT7	348
OR2A7	SPATA3	Q8NHX4	348
OR2A7	ZNF124	Q15973	322
OR2A7	CRIP3	Q6Q6R5	307
OR2A7	SSBP4	Q9BWG4	305
OR2A7	VN1R1	Q9GZP7	297
OR2A7	EMC6	Q9BV81	290
OR2A7	CNGA2	Q16280	266
OR2A7	RTP1	P59025	257
OR2A7	RUBCNL	Q9H714	257
OR2A7	CNGA4	Q8IV77	249

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, O43749, O60412, O76000, O76001, O76002, O95006, O95047, O95371, O95918, P0C626, P23266, P23269, P23272, P23273, P23274, P23275, P30953, P30955, P34982, P34984, P34986, P58173, P58181, P59922, P70526, Q13606, Q13607, Q15617, Q15619, Q5TZ20, Q60879, Q60890, Q6IEU7, Q6IF42, Q6UXT6, Q8N628, Q8NGA1, Q8NGC9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

269 predictions. Top by Δscore:

Variant	Effect	Δscore
7:144259177:C:CA	donor_gain	0.8500
7:144259192:G:C	donor_gain	0.8500
7:144259217:T:A	donor_gain	0.8100
7:144259381:T:TC	donor_gain	0.7600
7:144258937:T:TA	donor_gain	0.7400
7:144259700:A:C	donor_gain	0.6900
7:144259456:A:C	donor_gain	0.6700
7:144259125:A:AC	donor_gain	0.6500
7:144259126:C:CC	donor_gain	0.6500
7:144259280:TCACC:T	donor_gain	0.6500
7:144259391:T:TA	donor_gain	0.6500
7:144258958:A:AC	acceptor_gain	0.6300
7:144258951:C:CC	acceptor_gain	0.6200
7:144259278:CA:C	donor_gain	0.6000
7:144259387:A:T	donor_gain	0.5900
7:144259386:C:CT	donor_gain	0.5800
7:144258889:A:AC	donor_gain	0.5700
7:144259265:A:AC	donor_gain	0.5700
7:144259266:C:CC	donor_gain	0.5700
7:144259266:CAGAT:C	donor_gain	0.5700
7:144259401:C:CT	donor_gain	0.5700
7:144259383:C:T	donor_gain	0.5500
7:144258926:T:TA	donor_gain	0.5400
7:144258950:TCTG:T	acceptor_loss	0.5400
7:144258951:C:A	acceptor_loss	0.5400
7:144258958:A:C	acceptor_gain	0.5400
7:144258759:ACTAC:A	acceptor_gain	0.5300
7:144259197:C:CT	donor_gain	0.5300
7:144259301:C:CC	acceptor_gain	0.5300
7:144259428:G:GT	donor_gain	0.5300

AlphaMissense

2006 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:144259581:A:C	F16L	0.731
7:144259581:A:T	F16L	0.731
7:144259583:A:G	F16L	0.731
7:144259128:G:C	F167L	0.720
7:144259128:G:T	F167L	0.720
7:144259130:A:G	F167L	0.720
7:144259596:G:C	F11L	0.706
7:144259596:G:T	F11L	0.706
7:144259598:A:G	F11L	0.706
7:144259320:A:C	F103L	0.645
7:144259320:A:T	F103L	0.645
7:144259322:A:G	F103L	0.645
7:144259548:A:C	F27L	0.621
7:144259548:A:T	F27L	0.621
7:144259550:A:G	F27L	0.621
7:144259326:A:C	F101L	0.613
7:144259326:A:T	F101L	0.613
7:144259328:A:G	F101L	0.613
7:144259350:A:C	F93L	0.613
7:144259350:A:T	F93L	0.613
7:144259352:A:G	F93L	0.613
7:144259539:G:C	F30L	0.609
7:144259539:G:T	F30L	0.609
7:144259541:A:G	F30L	0.609
7:144259449:G:C	F60L	0.601
7:144259449:G:T	F60L	0.601
7:144259451:A:G	F60L	0.601
7:144259101:A:C	F176L	0.598
7:144259101:A:T	F176L	0.598
7:144259103:A:G	F176L	0.598

dbSNP variants (sampled 300 via entrez): RS1005232829 (7:144263675 G>A,T), RS1006867232 (7:144265062 T>C), RS1010306843 (7:144262747 G>A), RS1010420170 (7:144260414 C>T), RS1016532957 (7:144263734 C>A), RS1016585503 (7:144265080 T>A), RS1018504174 (7:144265707 G>C), RS1024453141 (7:144260454 C>A,T), RS1024567726 (7:144257371 T>A), RS10275843 (7:144259464 G>A), RS1029372879 (7:144265262 A>C,G), RS1029487431 (7:144263862 A>C), RS1033796944 (7:144260629 A>AGAC), RS1034610522 (7:144263133 T>G), RS1036791382 (7:144258921 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Diethylhexyl Phthalate	increases expression	1
Silicon Dioxide	increases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.