OR2AG2

Summary

OR2AG2 (olfactory receptor family 2 subfamily AG member 2, HGNC:15143) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 2AG2 (A6NM03). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 338755 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001004490

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15143
Approved symbol	OR2AG2
Name	olfactory receptor family 2 subfamily AG member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188124
Ensembl biotype	protein_coding
Entrez	338755

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641124, ENST00000641169

RefSeq mRNA: 2 — MANE Select: NM_001004490 NM_001004490, NM_001386053

CCDS: CCDS31413

Canonical transcript exons

ENST00000641124 — 2 exons

Exon	Start	End
ENSE00003811475	6765626	6769494
ENSE00003813907	6771622	6771976

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 74.48.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.56	silver quality
bone marrow cell	CL:0002092	55.28	gold quality
stromal cell of endometrium	CL:0002255	50.11	silver quality
prefrontal cortex	UBERON:0000451	48.04	gold quality
bone marrow	UBERON:0002371	47.76	gold quality
duodenum	UBERON:0002114	47.27	silver quality
colonic epithelium	UBERON:0000397	46.99	gold quality
primary visual cortex	UBERON:0002436	45.57	silver quality
sural nerve	UBERON:0015488	43.53	gold quality
ventricular zone	UBERON:0003053	43.44	gold quality
frontal cortex	UBERON:0001870	41.79	gold quality
urinary bladder	UBERON:0001255	41.53	silver quality
calcaneal tendon	UBERON:0003701	40.51	gold quality
lymph node	UBERON:0000029	40.43	silver quality
cortical plate	UBERON:0005343	40.10	gold quality
vermiform appendix	UBERON:0001154	39.29	silver quality
skeletal muscle tissue	UBERON:0001134	39.23	gold quality
muscle tissue	UBERON:0002385	39.14	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	38.64	silver quality
cerebral cortex	UBERON:0000956	38.09	gold quality
endometrium	UBERON:0001295	37.64	gold quality
rectum	UBERON:0001052	37.23	silver quality
adrenal tissue	UBERON:0018303	36.35	gold quality
islet of Langerhans	UBERON:0000006	36.18	silver quality
granulocyte	CL:0000094	36.05	gold quality
mucosa of transverse colon	UBERON:0004991	36.04	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
smooth muscle tissue	UBERON:0001135	35.28	gold quality
liver	UBERON:0002107	34.93	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6379	no	20.01
E-ANND-3	no	3.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma. (PMID:31836740)

Cross-species orthologs

23 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2ag2b	ENSMUSG00000036744
mus_musculus	Or2ag15	ENSMUSG00000051591
mus_musculus	Or2ag12	ENSMUSG00000051680
mus_musculus	Or2ag16	ENSMUSG00000059087
mus_musculus	Or2ag1b	ENSMUSG00000064223
mus_musculus	Or2ag20	ENSMUSG00000073900
mus_musculus	Or2ag19	ENSMUSG00000073901
mus_musculus	Or2ag18	ENSMUSG00000094493
mus_musculus	Or2ag17	ENSMUSG00000096714
mus_musculus	Or2ag13	ENSMUSG00000108948
mus_musculus	Or2ag1	ENSMUSG00000109058
mus_musculus	Or2ag2	ENSMUSG00000109354
rattus_norvegicus	Or2ag13	ENSRNOG00000071662
rattus_norvegicus	Or2ag17	ENSRNOG00000071858
rattus_norvegicus	Or2ag19	ENSRNOG00000074688
rattus_norvegicus	Or2ag19b	ENSRNOG00000075057
rattus_norvegicus	Or2ag2b	ENSRNOG00000077498
rattus_norvegicus	Or2ag1	ENSRNOG00000082291
rattus_norvegicus	Or2ag16	ENSRNOG00000084648
rattus_norvegicus	Or2ag20	ENSRNOG00000084956
rattus_norvegicus	Or2ag18	ENSRNOG00000087935
rattus_norvegicus	Or2ag16b	ENSRNOG00000091000
rattus_norvegicus	Or2ag2	ENSRNOG00000091170

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2AG2 — A6NM03 (reviewed: A6NM03)

All UniProt accessions (2): A0A126GWC6, A6NM03

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001004490, NP_001372982 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 4, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NM03-F1	86.73	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (2): 5, 19

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

88 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2AG2	RTP2	Q5QGT7	390
OR2AG2	TAS2R14	Q9NYV8	357
OR2AG2	TRIM49B	A6NDI0	349
OR2AG2	OR10A6	Q8NH74	334
OR2AG2	OR11H4	Q8NGC9	327
OR2AG2	GPR171	O14626	323
OR2AG2	DHX30	Q7L2E3	306
OR2AG2	F5GXT2	F5GXT2	298
OR2AG2	SLC7A3	Q8WY07	293
OR2AG2	FAM86C1P	Q9NVL1	290
OR2AG2	SPANXN5	Q5MJ07	273
OR2AG2	TRIM74	Q86UV6	270
OR2AG2	TRIM73	Q86UV7	253
OR2AG2	PTGIR	P43119	212
OR2AG2	TRPM6	Q9BX84	204

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

235 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6768169:ACTGG:A	acceptor_gain	0.8700
11:6768170:CTGGG:C	acceptor_gain	0.8200
11:6768313:C:CT	acceptor_gain	0.8200
11:6768171:T:A	acceptor_gain	0.8000
11:6768321:C:CT	acceptor_gain	0.7800
11:6768168:AACTG:A	acceptor_gain	0.7700
11:6768322:A:T	acceptor_gain	0.7100
11:6768297:C:CC	acceptor_gain	0.7000
11:6768443:C:T	acceptor_gain	0.6700
11:6768167:GAACT:G	acceptor_gain	0.6200
11:6768443:C:CT	acceptor_gain	0.6200
11:6768292:TAGGA:T	acceptor_gain	0.6000
11:6768588:CATA:C	donor_loss	0.6000
11:6768589:ATAC:A	donor_loss	0.6000
11:6768590:TAC:T	donor_loss	0.6000
11:6768591:A:C	donor_loss	0.6000
11:6768592:C:CT	donor_loss	0.6000
11:6768120:T:TC	acceptor_gain	0.5800
11:6768315:C:CT	acceptor_gain	0.5800
11:6768316:A:T	acceptor_gain	0.5700
11:6768326:A:AC	acceptor_gain	0.5700
11:6768372:CATA:C	donor_loss	0.5700
11:6768373:ATAC:A	donor_loss	0.5700
11:6768374:TACCT:T	donor_loss	0.5700
11:6768376:C:CG	donor_loss	0.5700
11:6768217:C:CT	acceptor_gain	0.5600
11:6768275:A:C	acceptor_gain	0.5400
11:6768317:A:AC	acceptor_gain	0.5400
11:6768263:T:TG	acceptor_gain	0.5300
11:6768255:T:TA	donor_gain	0.5200

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000426883 (11:6770001 A>G), RS1000514089 (11:6765752 A>G), RS1001211548 (11:6770616 C>G), RS1001314189 (11:6766828 T>A), RS1001630885 (11:6772097 G>A), RS1002203597 (11:6771782 G>A), RS1002216866 (11:6765820 A>G), RS1002990985 (11:6765277 T>C), RS1003223095 (11:6767241 C>G), RS1003227978 (11:6771499 G>A,C), RS1003316541 (11:6767432 T>C), RS1003616797 (11:6773165 A>C), RS1004108249 (11:6769272 T>G), RS1004369426 (11:6773709 T>C), RS1004380159 (11:6767440 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003030_4	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	3.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007679	oppositional defiant disorder measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.