OR2B11

Summary

OR2B11 (olfactory receptor family 2 subfamily B member 11, HGNC:31249) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2B11 (Q5JQS5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127623 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_001004492

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31249
Approved symbol	OR2B11
Name	olfactory receptor family 2 subfamily B member 11
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177535
Ensembl biotype	protein_coding
Entrez	127623

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000641149, ENST00000641527, ENST00000641613

RefSeq mRNA: 1 — MANE Select: NM_001004492 NM_001004492

CCDS: CCDS31090

Canonical transcript exons

ENST00000641149 — 2 exons

Exon	Start	End
ENSE00003814037	247449182	247455064
ENSE00003923682	247457639	247458104

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 61.42.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	61.42	gold quality
leukocyte	CL:0000738	55.84	gold quality
monocyte	CL:0000576	55.15	gold quality
bone marrow cell	CL:0002092	54.54	gold quality
bone marrow	UBERON:0002371	54.46	gold quality
blood	UBERON:0000178	50.50	gold quality
sural nerve	UBERON:0015488	48.60	silver quality
gall bladder	UBERON:0002110	46.37	gold quality
vermiform appendix	UBERON:0001154	44.66	gold quality
colonic epithelium	UBERON:0000397	41.69	gold quality
placenta	UBERON:0001987	41.50	silver quality
ventricular zone	UBERON:0003053	40.51	silver quality
lymph node	UBERON:0000029	40.18	silver quality
cortical plate	UBERON:0005343	39.94	gold quality
smooth muscle tissue	UBERON:0001135	39.92	silver quality
skeletal muscle tissue	UBERON:0001134	39.03	gold quality
lower esophagus mucosa	UBERON:0035834	39.00	gold quality
omental fat pad	UBERON:0010414	38.92	gold quality
primary visual cortex	UBERON:0002436	38.41	gold quality
mucosa of stomach	UBERON:0001199	38.40	silver quality
endometrium	UBERON:0001295	37.55	gold quality
left uterine tube	UBERON:0001303	37.35	gold quality
liver	UBERON:0002107	36.70	gold quality
urinary bladder	UBERON:0001255	36.15	silver quality
right lung	UBERON:0002167	36.15	silver quality
spleen	UBERON:0002106	35.50	gold quality
fallopian tube	UBERON:0003889	35.50	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
apex of heart	UBERON:0002098	35.43	gold quality
tonsil	UBERON:0002372	34.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.90

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2b11	ENSMUSG00000059610
rattus_norvegicus	Or2b11	ENSRNOG00000022244

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2B11 — Q5JQS5 (reviewed: Q5JQS5)

All UniProt accessions (2): A0A126GVY5, Q5JQS5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004492* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 5, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5JQS5-F1	88.47	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 101–193

Glycosylation sites (2): 5, 199

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 22 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MIKKELSEN_MCV6_ICP_WITH_H3K27ME3, MIKKELSEN_MEF_ICP_WITH_H3K27ME3, MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

242 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2B11	ZNF496	Q96IT1	559
OR2B11	C2CD4D	B7Z1M9	505
OR2B11	ZSCAN30	Q86W11	435
OR2B11	RNF151	Q2KHN1	434
OR2B11	GAB4	Q2WGN9	433
OR2B11	CBLL2	Q8N7E2	420
OR2B11	ODF4	Q2M2E3	369
OR2B11	DCAF4L2	Q8NA75	354
OR2B11	CBLN3	Q6UW01	327
OR2B11	SH3YL1	Q96HL8	317
OR2B11	NHLRC4	P0CG21	299
OR2B11	REC114	Q7Z4M0	290
OR2B11	MTMR7	Q9Y216	275
OR2B11	GPR137C	Q8N3F9	262
OR2B11	VN1R1	Q9GZP7	262

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76000, O76001, O76002, O95007, O95918, P0C626, P23266, P23267, P23270, P23272, P23274, P23275, P30955, P34985, P34986, P37072, P58173, P59922, Q15620, Q5JQS5, Q5TZ20, Q60882, Q60890, Q6IEU7, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGC0, Q8NGC2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

200 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247451605:G:C	donor_gain	0.8000
1:247451132:A:C	acceptor_gain	0.7600
1:247451132:A:AC	acceptor_gain	0.7100
1:247451640:C:CA	donor_gain	0.7100
1:247451686:T:TA	donor_gain	0.7100
1:247451590:G:A	donor_gain	0.7000
1:247451387:T:C	donor_gain	0.6900
1:247451692:G:C	donor_gain	0.6700
1:247451130:T:TC	acceptor_gain	0.6100
1:247451490:C:CT	donor_gain	0.6100
1:247451491:C:CT	donor_gain	0.6100
1:247451492:A:AA	donor_gain	0.5800
1:247451489:A:AC	donor_gain	0.5600
1:247451361:C:CT	donor_gain	0.5500
1:247451362:C:CT	donor_gain	0.5500
1:247451429:AC:A	donor_gain	0.5500
1:247451430:CC:C	donor_gain	0.5500
1:247451254:C:A	donor_gain	0.5400
1:247451273:C:CA	donor_gain	0.5400
1:247451095:CAGGG:C	acceptor_gain	0.5300
1:247451099:G:GC	acceptor_gain	0.5300
1:247451253:T:TA	donor_gain	0.5300
1:247451547:G:T	donor_gain	0.5300
1:247451604:A:AC	donor_gain	0.5300
1:247451099:G:C	acceptor_gain	0.5200
1:247451105:G:C	acceptor_gain	0.5200
1:247451176:G:C	donor_gain	0.5200
1:247451432:T:TG	acceptor_gain	0.5200
1:247451120:G:GC	acceptor_gain	0.5000
1:247451272:T:TA	donor_gain	0.5000

AlphaMissense

2057 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247451935:G:C	F16L	0.892
1:247451935:G:T	F16L	0.892
1:247451937:A:G	F16L	0.892
1:247451218:G:C	F255L	0.865
1:247451218:G:T	F255L	0.865
1:247451220:A:G	F255L	0.865
1:247451659:G:C	F108L	0.858
1:247451659:G:T	F108L	0.858
1:247451661:A:G	F108L	0.858
1:247451518:A:C	S155R	0.815
1:247451518:A:T	S155R	0.815
1:247451520:T:G	S155R	0.815
1:247451440:A:C	F181L	0.788
1:247451440:A:T	F181L	0.788
1:247451442:A:G	F181L	0.788
1:247451263:C:A	K240N	0.759
1:247451263:C:G	K240N	0.759
1:247451606:C:G	R126P	0.735
1:247451617:C:A	M122I	0.732
1:247451617:C:G	M122I	0.732
1:247451617:C:T	M122I	0.732
1:247451526:A:G	W153R	0.725
1:247451526:A:T	W153R	0.725
1:247451785:G:C	F66L	0.716
1:247451785:G:T	F66L	0.716
1:247451787:A:G	F66L	0.716
1:247451671:T:A	Q104H	0.710
1:247451671:T:G	Q104H	0.710
1:247451437:G:C	F182L	0.709
1:247451437:G:T	F182L	0.709

dbSNP variants (sampled 300 via entrez): RS1000020311 (1:247452925 T>C), RS1000031952 (1:247449211 A>G), RS1000334991 (1:247453899 A>G), RS1000345435 (1:247458208 T>C), RS1000728418 (1:247457342 G>C), RS1001361358 (1:247459669 G>A), RS1001412192 (1:247459853 G>A,C), RS1002338927 (1:247450097 T>G), RS1002598163 (1:247449660 T>G), RS1002711608 (1:247459559 T>C), RS1002765864 (1:247459776 C>T), RS1002903629 (1:247456783 C>A,T), RS1002956084 (1:247457074 G>A), RS1002991746 (1:247454514 T>C), RS1003007192 (1:247451959 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002444_1	Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid)	2.000000e-06
GCST90013663_42	Alanine aminotransferase levels	7.000000e-10
GCST90013664_66	Aspartate aminotransferase levels	4.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005680	omega-6 polyunsaturated fatty acid measurement
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs35305980	OR2B11		0.00	0

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Vehicle Emissions	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.