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OR2B6

gene
On this page

Also known as OR6-31dJ408B20.2OR5-40OR5-41

Summary

OR2B6 (olfactory receptor family 2 subfamily B member 6, HGNC:8241) is a protein-coding gene on chromosome 6p22.1, encoding Olfactory receptor 2B6 (P58173). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26212 — RefSeq curated summary.

At a glance

  • GWAS associations: 25
  • Clinical variants (ClinVar): 46 total
  • MANE Select transcript: NM_012367

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:8241
Approved symbolOR2B6
Nameolfactory receptor family 2 subfamily B member 6
Location6p22.1
Locus typegene with protein product
StatusApproved
AliasesOR6-31, dJ408B20.2, OR5-40, OR5-41
Ensembl geneENSG00000124657
Ensembl biotypeprotein_coding
Entrez26212

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000244623

RefSeq mRNA: 1 — MANE Select: NM_012367 NM_012367

CCDS: CCDS4642

Canonical transcript exons

ENST00000244623 — 1 exons

ExonStartEnd
ENSE000008485002795724127958182

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 61.53.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
mucosa of transverse colonUBERON:000499161.53gold quality
monocyteCL:000057661.30gold quality
mononuclear cellCL:000084261.19gold quality
leukocyteCL:000073861.07gold quality
tibialis anteriorUBERON:000138560.58silver quality
endometrium epitheliumUBERON:000481159.68gold quality
spermCL:000001958.51gold quality
male germ cellCL:000001558.04gold quality
cranial nerve IIUBERON:000094157.97silver quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099157.57gold quality
gingival epitheliumUBERON:000194952.74gold quality
bloodUBERON:000017852.18gold quality
oocyteCL:000002352.14gold quality
deltoidUBERON:000147651.96gold quality
quadriceps femorisUBERON:000137751.60gold quality
thymusUBERON:000237051.54silver quality
granulocyteCL:000009451.12silver quality
Brodmann (1909) area 10UBERON:001354150.79gold quality
vastus lateralisUBERON:000137950.52gold quality
ileal mucosaUBERON:000033150.49silver quality
frontal poleUBERON:000279550.41gold quality
middle frontal gyrusUBERON:000270250.30gold quality
paraflocculusUBERON:000535150.18gold quality
myocardiumUBERON:000234949.46gold quality
Brodmann (1909) area 46UBERON:000648349.30gold quality
blood vessel layerUBERON:000479749.29gold quality
oviduct epitheliumUBERON:000480449.28gold quality
cerebellar vermisUBERON:000472049.25gold quality
cervix squamous epitheliumUBERON:000692249.20gold quality
hair follicleUBERON:000207349.18gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no1.80

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusOr2b6ENSMUSG00000036658
rattus_norvegicusOr2b2ENSRNOG00000084603

Paralogs (92): OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2B6 — P58173 (reviewed: P58173)

Alternative names: Hs6M1-32, Olfactory receptor 2B1, Olfactory receptor 2B5, Olfactory receptor 5-40, Olfactory receptor 6-31, Olfactory receptor OR6-4

All UniProt accessions (1): P58173

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_036499* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000276GPCR_RhodpsnFamily
IPR000725Olfact_rcptFamily
IPR017452GPCR_Rhodpsn_7TMDomain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P58173-F187.960.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-9752946Expression and translocation of olfactory receptors

MSigDB gene sets: 75 (showing top): MORF_MSH3, MORF_BRCA1, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, MORF_RAD51L3, MORF_CTSB, MORF_IL4, MORF_PRKCA, KEGG_OLFACTORY_TRANSDUCTION, MORF_THPO, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, MORF_ATF2, MORF_BCL2L11, MORF_PPP2R5B, GAL_LEUKEMIC_STEM_CELL_UP

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Olfactory Signaling Pathway1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transmembrane signaling receptor activity2
sensory perception of smell1
detection of chemical stimulus involved in sensory perception1
cell communication1
cellular process1
signaling1
regulation of cellular process1
cellular response to stimulus1
G protein-coupled receptor activity1
signal transduction1
sensory perception of chemical stimulus1
G protein-coupled receptor signaling pathway1
detection of chemical stimulus involved in sensory perception of smell1
membrane1
cell periphery1
cellular anatomical structure1

Protein interactions and networks

STRING

168 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
OR2B6GPR160Q9UJ42400
OR2B6HDDC2Q7Z4H3370
OR2B6LRRC46Q96FV0369
OR2B6SEC14L5O43304348
OR2B6FRMD1Q8N878327
OR2B6PCED1BQ96HM7310
OR2B6H2AC14Q99878258
OR2B6SEZ6Q53EL9257
OR2B6ZSCAN12O43309256
OR2B6RCAN3Q9UKA8247
OR2B6TRIM58Q8NG06240
OR2B6SLC37A1P57057235
OR2B6CEP55Q53EZ4229
OR2B6PPP2R5DQ14738227
OR2B6XKR6Q5GH73224

IntAct

2 interactions, top by confidence:

ABTypeScore
Mpsi-mi:“MI:0914”(association)0.350

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance40
Likely benign6
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

181 predictions. Top by Δscore:

VariantEffectΔscore
6:27957309:G:GTdonor_gain0.9000
6:27957848:G:GGdonor_gain0.8800
6:27957327:G:GAdonor_gain0.8700
6:27957847:A:AGdonor_gain0.8600
6:27957998:GTACA:Gacceptor_gain0.8600
6:27957508:A:Tdonor_gain0.8500
6:27957997:A:AGacceptor_gain0.8300
6:27957998:G:GGacceptor_gain0.8300
6:27957363:C:Tdonor_gain0.7900
6:27957998:GTAC:Gacceptor_gain0.7700
6:27957998:GT:Gacceptor_gain0.7600
6:27957466:T:Gdonor_gain0.7500
6:27957996:T:Gacceptor_gain0.7200
6:27957270:G:GTdonor_gain0.7100
6:27957329:T:TAdonor_gain0.7100
6:27957507:G:GTdonor_gain0.7000
6:27957994:TATA:Tacceptor_loss0.7000
6:27957996:TAGTA:Tacceptor_loss0.7000
6:27957997:A:ATacceptor_loss0.7000
6:27957283:C:Gdonor_gain0.6900
6:27957326:T:TAdonor_gain0.6900
6:27957491:A:Gdonor_gain0.6900
6:27957271:G:GTdonor_gain0.6800
6:27957416:T:Gdonor_gain0.6800
6:27957331:T:TGdonor_gain0.6700
6:27957998:GTA:Gacceptor_gain0.6600
6:27957469:AC:Adonor_gain0.6500
6:27957602:A:Gdonor_gain0.6400
6:27957330:C:Adonor_gain0.6200
6:27957353:C:Gdonor_gain0.6200

AlphaMissense

2021 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
6:27957274:T:CF12L0.864
6:27957276:T:AF12L0.864
6:27957276:T:GF12L0.864
6:27957289:T:CF17L0.825
6:27957291:C:AF17L0.825
6:27957291:C:GF17L0.825
6:27957607:T:CF123L0.764
6:27957609:T:AF123L0.764
6:27957609:T:GF123L0.764
6:27957769:T:CF177L0.753
6:27957771:T:AF177L0.753
6:27957771:T:GF177L0.753
6:27957421:T:CF61L0.729
6:27957423:T:AF61L0.729
6:27957423:T:GF61L0.729
6:27957952:T:CF238L0.728
6:27957954:T:AF238L0.728
6:27957954:T:GF238L0.728
6:27957594:G:AM118I0.711
6:27957594:G:CM118I0.711
6:27957594:G:TM118I0.711
6:27957424:T:CF62L0.708
6:27957426:T:AF62L0.708
6:27957426:T:GF62L0.708
6:27957685:T:AW149R0.705
6:27957685:T:CW149R0.705
6:27957991:T:CF251L0.704
6:27957993:T:AF251L0.704
6:27957993:T:GF251L0.704
6:27957948:A:CK236N0.701

dbSNP variants (sampled 300 via entrez): RS1001246256 (6:27958290 T>A), RS1001416608 (6:27956086 C>G,T), RS1001491243 (6:27955655 C>A,T), RS1002700917 (6:27957154 A>G), RS1002916700 (6:27956900 A>C), RS1003088603 (6:27957835 C>G,T), RS1005398872 (6:27957757 G>A,C), RS1007057782 (6:27957252 A>T), RS1008029705 (6:27956884 G>A,T), RS1008508967 (6:27955987 A>G), RS1008898395 (6:27956529 C>A,T), RS1010496280 (6:27956096 T>C), RS1010683142 (6:27955624 A>G), RS1011046431 (6:27955964 G>A,T), RS1011574140 (6:27957022 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

StudyTraitp-value
GCST004521_112Autism spectrum disorder or schizophrenia3.000000e-26
GCST004521_115Autism spectrum disorder or schizophrenia3.000000e-16
GCST004521_116Autism spectrum disorder or schizophrenia3.000000e-16
GCST004521_166Autism spectrum disorder or schizophrenia4.000000e-24
GCST004521_212Autism spectrum disorder or schizophrenia5.000000e-14
GCST004521_22Autism spectrum disorder or schizophrenia2.000000e-11
GCST004521_23Autism spectrum disorder or schizophrenia2.000000e-11
GCST004521_6Autism spectrum disorder or schizophrenia2.000000e-15
GCST004521_73Autism spectrum disorder or schizophrenia8.000000e-11
GCST004521_77Autism spectrum disorder or schizophrenia1.000000e-19
GCST004749_72Lung cancer in ever smokers1.000000e-08
GCST004750_88Squamous cell lung carcinoma2.000000e-10
GCST004750_89Squamous cell lung carcinoma2.000000e-10
GCST006940_163Neurociticism2.000000e-08
GCST007267_213Systolic blood pressure3.000000e-08
GCST008921_6Asthma and major depressive disorder1.000000e-09
GCST010002_50Refractive error4.000000e-34
GCST010142_16Fish- and plant-related diet2.000000e-10
GCST010142_19Fish- and plant-related diet4.000000e-10
GCST010142_34Fish- and plant-related diet7.000000e-09
GCST010142_35Fish- and plant-related diet8.000000e-09
GCST010142_42Fish- and plant-related diet1.000000e-08
GCST010142_7Fish- and plant-related diet3.000000e-12
GCST010702_75Subcortical volume (MOSTest)3.000000e-11
GCST010703_272Brain morphology (MOSTest)7.000000e-16

EFO canonical traits (4, from GWAS)

EFO IDTrait name
EFO:0007660neuroticism measurement
EFO:0006335systolic blood pressure
EFO:0008111diet measurement
EFO:0004346neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

ChemicalActions (top 5)PubMed papers
(+)-JQ1 compoundincreases expression3
sotorasibaffects cotreatment, increases expression1
propionaldehydedecreases expression1
2-methyl-4-isothiazolin-3-oneincreases expression1
abrineincreases expression1
licochalcone Bincreases expression1
trametinibincreases expression, affects cotreatment1
NVP-BKM120affects cotreatment, increases expression1
Benzo(a)pyrenedecreases methylation1
Phthalic Acidsincreases methylation1
Aflatoxin B1decreases methylation1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot