OR2C3

Summary

OR2C3 (olfactory receptor family 2 subfamily C member 3, HGNC:15005) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2C3 (Q8N628). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81472 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_198074

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15005
Approved symbol	OR2C3
Name	olfactory receptor family 2 subfamily C member 3
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OST742
Ensembl gene	ENSG00000196242
Ensembl biotype	protein_coding
Entrez	81472

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000366487, ENST00000641802, ENST00000673193

RefSeq mRNA: 1 — MANE Select: NM_198074 NM_198074

CCDS: CCDS1634

Canonical transcript exons

ENST00000641802 — 3 exons

Exon	Start	End
ENSE00001828853	247524677	247532540
ENSE00003811703	247533507	247533878
ENSE00003811954	247536168	247536440

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 71.52.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.52	gold quality
ventricular zone	UBERON:0003053	53.79	gold quality
ganglionic eminence	UBERON:0004023	51.82	silver quality
mucosa of stomach	UBERON:0001199	49.58	gold quality
smooth muscle tissue	UBERON:0001135	48.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	48.67	gold quality
placenta	UBERON:0001987	47.81	gold quality
cortical plate	UBERON:0005343	46.87	gold quality
testis	UBERON:0000473	46.70	gold quality
endometrium	UBERON:0001295	46.39	silver quality
right testis	UBERON:0004534	46.26	gold quality
gall bladder	UBERON:0002110	45.70	gold quality
muscle tissue	UBERON:0002385	45.51	gold quality
islet of Langerhans	UBERON:0000006	45.35	gold quality
leukocyte	CL:0000738	45.29	silver quality
left testis	UBERON:0004533	45.22	gold quality
monocyte	CL:0000576	45.08	silver quality
bone marrow cell	CL:0002092	44.30	gold quality
vermiform appendix	UBERON:0001154	43.76	gold quality
skeletal muscle tissue	UBERON:0001134	43.65	gold quality
myometrium	UBERON:0001296	42.50	gold quality
superior frontal gyrus	UBERON:0002661	42.42	gold quality
lymph node	UBERON:0000029	41.74	gold quality
prostate gland	UBERON:0002367	41.61	gold quality
bone marrow	UBERON:0002371	41.42	gold quality
primary visual cortex	UBERON:0002436	41.42	gold quality
colonic epithelium	UBERON:0000397	41.31	gold quality
urinary bladder	UBERON:0001255	40.80	silver quality
sural nerve	UBERON:0015488	39.89	gold quality
calcaneal tendon	UBERON:0003701	39.79	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95
E-MTAB-6386	no	3.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

37 targeting OR2C3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-202-5P	99.78	67.65	991
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-8064	99.45	66.92	875
HSA-MIR-4735-5P	99.43	68.49	1780
HSA-MIR-16-2-3P	99.29	70.60	1954
HSA-MIR-195-3P	99.29	70.61	1954
HSA-MIR-371A-5P	99.08	66.51	1914
HSA-MIR-320A-5P	98.88	66.75	1248
HSA-MIR-655-5P	98.74	65.93	888

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2C3 — Q8N628 (reviewed: Q8N628)

Alternative names: Olfactory receptor 2C4, Olfactory receptor 2C5, Olfactory receptor OR1-30

All UniProt accessions (1): Q8N628

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_932340* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N628-F1	86.84	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 37 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MIR302C_5P, MIR4692

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

120 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2C3	GCSAML	Q5JQS6	432
OR2C3	TMEM232	C9JQI7	377
OR2C3	KLHL29	Q96CT2	377
OR2C3	KRT85	P78386	348
OR2C3	CPLX3	Q8WVH0	327
OR2C3	PKIB	Q9C010	311
OR2C3	NPFFR1	Q9GZQ6	307
OR2C3	ST6GALNAC3	Q8NDV1	301
OR2C3	ARID5B	Q14865	296
OR2C3	ZRANB2	O95218	295
OR2C3	KCNE4	Q8WWG9	274
OR2C3	SEPTIN8	Q92599	273
OR2C3	MAIP1	Q8WWC4	248
OR2C3	RIN3	Q8TB24	223
OR2C3	EIF2S2	P20042	211

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

434 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247533506:CCTTA:C	donor_gain	0.9900
1:247525960:GA:G	donor_gain	0.9800
1:247532540:CCTG:C	acceptor_loss	0.9800
1:247532541:C:A	acceptor_loss	0.9800
1:247532542:T:C	acceptor_loss	0.9800
1:247533502:CCTA:C	donor_loss	0.9800
1:247533504:TA:T	donor_loss	0.9800
1:247533505:A:AG	donor_loss	0.9800
1:247533506:C:A	donor_loss	0.9800
1:247533510:A:AC	donor_gain	0.9800
1:247533511:C:CC	donor_gain	0.9800
1:247525333:GGC:G	donor_gain	0.9500
1:247532538:CAC:C	acceptor_gain	0.9500
1:247533600:T:TA	donor_gain	0.9500
1:247526938:AG:A	acceptor_gain	0.9400
1:247526939:GG:G	acceptor_gain	0.9400
1:247533505:A:AC	donor_gain	0.9400
1:247533506:C:CC	donor_gain	0.9400
1:247525907:GATT:G	donor_gain	0.9200
1:247532537:CCAC:C	acceptor_gain	0.9200
1:247532538:CACC:C	acceptor_gain	0.9200
1:247532536:GCCAC:G	acceptor_gain	0.9100
1:247532537:CCACC:C	acceptor_gain	0.9100
1:247532541:C:CC	acceptor_gain	0.9100
1:247527050:CTGAG:C	donor_loss	0.9000
1:247527051:TGAG:T	donor_loss	0.9000
1:247527052:GAGGT:G	donor_loss	0.9000
1:247527053:AGG:A	donor_loss	0.9000
1:247527054:GG:G	donor_loss	0.9000
1:247527055:GTAC:G	donor_loss	0.9000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000005905 (1:247531025 G>C,T), RS1000236980 (1:247524698 T>G), RS1000610833 (1:247526153 T>G), RS1000963501 (1:247537281 G>A), RS1001275832 (1:247529735 T>G), RS1001439181 (1:247535140 T>C), RS1001845824 (1:247525729 TCTG>T), RS1002281482 (1:247527990 G>A), RS1002333936 (1:247527738 G>A,C,T), RS1002516163 (1:247533010 G>T), RS1002824786 (1:247537374 G>A), RS1002852594 (1:247533692 T>C), RS1003011278 (1:247530818 C>A,G), RS1003063389 (1:247537159 A>G,T), RS1003165513 (1:247536490 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000464_11	Acute lymphoblastic leukemia (childhood)	7.000000e-06
GCST90016667_32	Spleen volume	3.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1
Aflatoxin B1	increases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.