OR2F2

Summary

OR2F2 (olfactory receptor family 2 subfamily F member 2, HGNC:8247) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 2F2 (O95006). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 135948 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 58 total
• MANE Select transcript: NM_001004685

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8247
Approved symbol	OR2F2
Name	olfactory receptor family 2 subfamily F member 2
Location	7q35
Locus type	gene with protein product
Status	Approved
Aliases	OR7-1
Ensembl gene	ENSG00000221910
Ensembl biotype	protein_coding
Entrez	135948

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000408955

RefSeq mRNA: 1 — MANE Select: NM_001004685 NM_001004685

CCDS: CCDS43666

Canonical transcript exons

ENST00000408955 — 1 exons

Exon	Start	End
ENSE00001565745	143935233	143936186

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 37.42.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	37.42	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
calcaneal tendon	UBERON:0003701	32.06	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
monocyte	CL:0000576	29.89	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.69	gold quality
prefrontal cortex	UBERON:0000451	29.40	gold quality
tonsil	UBERON:0002372	29.02	gold quality
liver	UBERON:0002107	28.80	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.87	gold quality
placenta	UBERON:0001987	27.69	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.93	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.10	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
uterine cervix	UBERON:0000002	25.25	gold quality
muscle of leg	UBERON:0001383	25.22	gold quality
right lung	UBERON:0002167	24.97	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2f1	ENSMUSG00000095831
rattus_norvegicus	Or2f1	ENSRNOG00000077246

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2F2 — O95006 (reviewed: O95006)

Alternative names: Olfactory receptor 7-1, Olfactory receptor OR7-6

All UniProt accessions (1): O95006

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004685* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95006-F1	88.68	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 39 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, CTIP_DN.V1_UP, IL15_UP.V1_DN, IL21_UP.V1_DN

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

54 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2F2	RNF214	Q8ND24	625
OR2F2	TCAF1	Q9Y4C2	577
OR2F2	CDK5RAP3	Q96JB5	445
OR2F2	UBASH3A	P57075	370
OR2F2	PAK4	O96013	271
OR2F2	MPPED2	Q15777	249
OR2F2	SMAD5	Q99717	220
OR2F2	EDARADD	Q8WWZ3	219
OR2F2	AJAP1	Q9UKB5	204
OR2F2	ALLC	Q8N6M5	201
OR2F2	BACE1	P56817	181
OR2F2	AKT2	P31751	176
OR2F2	RHOU	Q7L0Q8	175
OR2F2	TNFSF13B	Q9Y275	174
OR2F2	HAUS3	Q68CZ6	73

IntAct

0 interactions, top by confidence:

BioGRID (3): OR2F2 (Affinity Capture-MS), OR2F2 (Negative Genetic), OR2F2 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

235 predictions. Top by Δscore:

Variant	Effect	Δscore
7:143935876:T:TA	acceptor_gain	0.8600
7:143935870:T:A	acceptor_gain	0.8300
7:143935887:A:AG	acceptor_gain	0.8000
7:143935879:T:A	acceptor_gain	0.7800
7:143935886:C:G	acceptor_gain	0.7700
7:143935887:ATCCG:A	acceptor_gain	0.7600
7:143935890:C:CA	acceptor_gain	0.7600
7:143935887:ATCC:A	acceptor_gain	0.7500
7:143935885:A:AG	acceptor_gain	0.7400
7:143935891:G:A	acceptor_gain	0.7400
7:143935871:G:A	acceptor_gain	0.6900
7:143935888:T:G	acceptor_gain	0.6900
7:143935866:T:TA	acceptor_gain	0.6700
7:143935897:T:G	acceptor_gain	0.6700
7:143935778:A:AG	acceptor_gain	0.6600
7:143935779:G:GG	acceptor_gain	0.6600
7:143935779:GCT:G	acceptor_gain	0.6600
7:143935860:C:G	acceptor_gain	0.6600
7:143935906:T:G	acceptor_gain	0.6300
7:143935912:A:AG	acceptor_gain	0.6300
7:143935913:G:GG	acceptor_gain	0.6300
7:143935931:A:T	donor_gain	0.6200
7:143935840:GCATT:G	acceptor_gain	0.6100
7:143935896:A:AG	acceptor_gain	0.6100
7:143935930:G:T	donor_gain	0.6000
7:143935985:C:CG	donor_gain	0.6000
7:143935859:A:AG	acceptor_gain	0.5900
7:143935852:T:TA	acceptor_gain	0.5800
7:143935902:A:AG	acceptor_gain	0.5800
7:143935903:C:G	acceptor_gain	0.5800

AlphaMissense

2053 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:143935266:T:C	F12L	0.955
7:143935268:T:A	F12L	0.955
7:143935268:T:G	F12L	0.955
7:143935314:T:C	F28L	0.895
7:143935316:T:A	F28L	0.895
7:143935316:T:G	F28L	0.895
7:143935458:A:C	S76R	0.894
7:143935460:C:A	S76R	0.894
7:143935460:C:G	S76R	0.894
7:143935566:T:C	F112L	0.854
7:143935568:T:A	F112L	0.854
7:143935568:T:G	F112L	0.854
7:143935267:T:C	F12S	0.832
7:143935839:A:C	S203R	0.827
7:143935841:C:A	S203R	0.827
7:143935841:C:G	S203R	0.827
7:143935722:T:C	F164L	0.808
7:143935724:T:A	F164L	0.808
7:143935724:T:G	F164L	0.808
7:143935323:T:C	F31L	0.804
7:143935325:C:A	F31L	0.804
7:143935325:C:G	F31L	0.804
7:143935536:T:C	F102L	0.802
7:143935538:T:A	F102L	0.802
7:143935538:T:G	F102L	0.802
7:143935474:T:C	L81P	0.795
7:143935507:T:C	I92T	0.793
7:143935767:T:C	C179R	0.785
7:143935767:T:A	C179S	0.782
7:143935768:G:C	C179S	0.782

dbSNP variants (sampled 300 via entrez): RS1000403539 (7:143934578 T>G), RS1002193646 (7:143933540 T>C), RS1002868650 (7:143936345 G>T), RS1003200142 (7:143935083 TG>T), RS1005793930 (7:143934862 G>A), RS1007173107 (7:143935974 G>T), RS1007295633 (7:143933344 A>G), RS1013892276 (7:143934788 T>C), RS1014923513 (7:143934405 G>T), RS1016152725 (7:143933318 T>C), RS1016358933 (7:143936679 A>G), RS1016823808 (7:143936403 G>A), RS1017146452 (7:143934926 G>A,C), RS1020311045 (7:143935831 T>C), RS1020550081 (7:143934665 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005588_37	Idiopathic dilated cardiomyopathy	5.000000e-06
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009094	idiopathic dilated cardiomyopathy
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium	decreases expression, increases abundance	1
Methotrexate	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Particulate Matter	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.