OR2G2

Summary

OR2G2 (olfactory receptor family 2 subfamily G member 2, HGNC:15007) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2G2 (Q8NGZ5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81470 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001001915

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15007
Approved symbol	OR2G2
Name	olfactory receptor family 2 subfamily G member 2
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177489
Ensembl biotype	protein_coding
Entrez	81470

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000320065

RefSeq mRNA: 1 — MANE Select: NM_001001915 NM_001001915

CCDS: CCDS31092

Canonical transcript exons

ENST00000320065 — 1 exons

Exon	Start	End
ENSE00001280164	247588360	247589313

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 77.11.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.11	silver quality
granulocyte	CL:0000094	40.91	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.92	gold quality
leukocyte	CL:0000738	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	27.95	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	26.92	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.94	gold quality
right lobe of liver	UBERON:0001114	24.64	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2G2 — Q8NGZ5 (reviewed: Q8NGZ5)

Alternative names: Olfactory receptor OR1-32

All UniProt accessions (1): Q8NGZ5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001915* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGZ5-F1	82.32	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 100–192

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2G2	KRTAP5-10	Q6L8G5	585
OR2G2	KRTAP5-7	Q6L8G8	573
OR2G2	KRTAP5-11	Q6L8G4	528
OR2G2	KRTAP5-5	Q701N2	479
OR2G2	CASP5	P51878	278
OR2G2	TAS2R60	P59551	270
OR2G2	A6NFB4	A6NFB4	253
OR2G2	MAIP1	Q8WWC4	248
OR2G2	EIF2S2	P20042	211
OR2G2	DNAJC28	Q9NX36	211
OR2G2	DNAJC24	Q6P3W2	208
OR2G2	RMP64	Q6NW34	204
OR2G2	STOX2	Q9P2F5	193
OR2G2	RTP1	P59025	192
OR2G2	PRSS56	P0CW18	192

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A4D2G3, A6NCV1, A6NF89, A6NFC9, A6NIJ9, A6NJZ3, A6NL26, O14581, O76000, O76001, O76002, O76099, O76100, O95221, O95371, O95918, P0DN82, P23275, P34984, P35898, P58173, P58182, P59922, P70526, Q13607, Q15615, Q15622, Q5JQS5, Q5TZ20, Q60883, Q60887, Q60889, Q60890, Q60892, Q60894, Q6IEU7, Q6IF82, Q7TR96, Q7Z3T1, Q8N628

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

375 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247589012:T:TA	acceptor_gain	0.7600
1:247588958:C:G	donor_gain	0.7300
1:247588992:A:AG	acceptor_gain	0.7300
1:247588993:G:GG	acceptor_gain	0.7300
1:247589008:ATCCT:A	acceptor_gain	0.7200
1:247589124:T:TA	acceptor_gain	0.6900
1:247588792:AT:A	acceptor_gain	0.6800
1:247589013:G:A	acceptor_gain	0.6600
1:247588957:GC:G	donor_gain	0.6500
1:247589022:T:A	acceptor_gain	0.6400
1:247588971:GGCT:G	donor_gain	0.6300
1:247589028:C:G	acceptor_gain	0.6300
1:247589041:GT:G	acceptor_gain	0.6300
1:247588618:AACCT:A	donor_gain	0.6000
1:247589049:GAT:G	donor_gain	0.6000
1:247588954:GAGGC:G	donor_gain	0.5900
1:247589027:A:AG	acceptor_gain	0.5900
1:247589180:G:T	donor_gain	0.5900
1:247589029:A:AG	acceptor_gain	0.5800
1:247588911:C:A	donor_gain	0.5700
1:247589296:G:GT	donor_gain	0.5700
1:247588792:A:AG	acceptor_gain	0.5600
1:247588574:T:A	acceptor_gain	0.5500
1:247588793:T:G	acceptor_gain	0.5500
1:247588793:T:TA	acceptor_gain	0.5500
1:247588993:GT:G	acceptor_gain	0.5500
1:247589030:T:G	acceptor_gain	0.5500
1:247588956:GGC:G	donor_gain	0.5400
1:247589109:G:GA	donor_gain	0.5400
1:247589126:G:GT	donor_gain	0.5400

AlphaMissense

2060 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247588402:T:C	F15L	0.785
1:247588404:C:A	F15L	0.785
1:247588404:C:G	F15L	0.785
1:247588417:T:C	F20L	0.725
1:247588419:T:A	F20L	0.725
1:247588419:T:G	F20L	0.725
1:247588585:T:C	F76L	0.611
1:247588587:C:A	F76L	0.611
1:247588587:C:G	F76L	0.611
1:247588897:T:C	F180L	0.603
1:247588899:C:A	F180L	0.603
1:247588899:C:G	F180L	0.603
1:247589119:T:C	F254L	0.581
1:247589121:T:A	F254L	0.581
1:247589121:T:G	F254L	0.581

dbSNP variants (sampled 300 via entrez): RS1000275596 (1:247587324 C>T), RS1001978113 (1:247588210 A>C), RS1002307936 (1:247586846 A>G,T), RS1003729313 (1:247589403 T>C), RS1004268974 (1:247589707 A>G), RS1005146439 (1:247588196 CG>C), RS1005473407 (1:247589530 A>G), RS1009871740 (1:247588549 T>C,G), RS1010460694 (1:247587372 T>A), RS1011573802 (1:247588889 T>C), RS1011627557 (1:247588517 G>A,T), RS1012449347 (1:247587945 G>T), RS1013204332 (1:247589252 A>C,G), RS1013339057 (1:247587953 A>G), RS1014306020 (1:247587065 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
bisphenol S	decreases methylation	1
Benzo(a)pyrene	affects methylation	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.