OR2G3

Summary

OR2G3 (olfactory receptor family 2 subfamily G member 3, HGNC:15008) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2G3 (Q8NGZ4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81469 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001001914

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15008
Approved symbol	OR2G3
Name	olfactory receptor family 2 subfamily G member 3
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177476
Ensembl biotype	protein_coding
Entrez	81469

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000320002

RefSeq mRNA: 1 — MANE Select: NM_001001914 NM_001001914

CCDS: CCDS31093

Canonical transcript exons

ENST00000320002 — 1 exons

Exon	Start	End
ENSE00001280080	247605586	247606515

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 43.38.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	43.38	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.70	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.86	gold quality
monocyte	CL:0000576	29.21	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	26.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.41	gold quality
myometrium	UBERON:0001296	24.21	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2G3 — Q8NGZ4 (reviewed: Q8NGZ4)

Alternative names: Olfactory receptor OR1-33

All UniProt accessions (2): A0A126GVX0, Q8NGZ4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001914* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGZ4-F1	90.92	0.73

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

116 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2G3	KRTAP5-11	Q6L8G4	667
OR2G3	KRTAP5-10	Q6L8G5	631
OR2G3	KRTAP5-7	Q6L8G8	608
OR2G3	KRTAP5-5	Q701N2	544
OR2G3	CASP5	P51878	500
OR2G3	TSSC4	Q9Y5U2	461
OR2G3	MRC1	P22897	410
OR2G3	GH1	P01241	397
OR2G3	CASP1	P29466	381
OR2G3	SETDB2	Q96T68	355
OR2G3	A0A3B3ISS9	A0A3B3ISS9	353
OR2G3	DHRS3	O75911	330
OR2G3	KLC3	Q6P597	324
OR2G3	FGL1	Q08830	322
OR2G3	A6NFB4	A6NFB4	319

IntAct

0 interactions, top by confidence:

BioGRID (1): OR2G3 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

391 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247606239:T:G	acceptor_gain	0.8400
1:247606123:G:GT	donor_gain	0.8000
1:247606238:AT:A	acceptor_gain	0.7700
1:247606192:A:AG	acceptor_gain	0.7300
1:247606193:G:GG	acceptor_gain	0.7300
1:247605658:G:GT	donor_gain	0.7000
1:247606215:A:AG	acceptor_gain	0.7000
1:247606215:ACCAG:A	acceptor_loss	0.6900
1:247606217:CAGC:C	acceptor_loss	0.6900
1:247606219:GC:G	acceptor_gain	0.6900
1:247606214:CACCA:C	acceptor_loss	0.6800
1:247606218:A:AG	acceptor_gain	0.6800
1:247606219:G:GG	acceptor_gain	0.6800
1:247606080:A:G	acceptor_gain	0.6700
1:247605655:G:GT	donor_gain	0.6500
1:247606079:A:AG	acceptor_gain	0.6500
1:247606206:T:A	acceptor_loss	0.6500
1:247606219:GCACT:G	acceptor_gain	0.6500
1:247605833:T:G	donor_gain	0.6400
1:247605983:T:TA	donor_gain	0.6400
1:247605984:A:AA	donor_gain	0.6400
1:247606203:T:A	acceptor_loss	0.6300
1:247606219:GCA:G	acceptor_gain	0.6300
1:247606239:T:TA	acceptor_gain	0.6200
1:247606255:GCT:G	acceptor_gain	0.6100
1:247605659:C:T	donor_gain	0.6000
1:247606039:G:GA	donor_gain	0.6000
1:247606216:C:G	acceptor_gain	0.6000
1:247605596:GCAA:G	donor_gain	0.5900
1:247606288:C:T	donor_gain	0.5900

AlphaMissense

2016 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247605634:T:C	F17L	0.875
1:247605636:C:A	F17L	0.875
1:247605636:C:G	F17L	0.875
1:247605619:T:C	F12L	0.827
1:247605621:C:A	F12L	0.827
1:247605621:C:G	F12L	0.827
1:247606336:T:C	F251L	0.780
1:247606338:C:A	F251L	0.780
1:247606338:C:G	F251L	0.780
1:247606114:T:C	F177L	0.745
1:247606116:T:A	F177L	0.745
1:247606116:T:G	F177L	0.745
1:247605811:A:C	S76R	0.720
1:247605813:C:A	S76R	0.720
1:247605813:C:G	S76R	0.720
1:247605939:G:A	M118I	0.712
1:247605939:G:C	M118I	0.712
1:247605939:G:T	M118I	0.712
1:247605667:T:C	F28L	0.693
1:247605669:T:A	F28L	0.693
1:247605669:T:G	F28L	0.693
1:247605766:T:C	F61L	0.693
1:247605768:T:A	F61L	0.693
1:247605768:T:G	F61L	0.693
1:247605802:T:C	F73L	0.692
1:247605804:C:A	F73L	0.692
1:247605804:C:G	F73L	0.692
1:247606036:A:C	S151R	0.684
1:247606038:T:A	S151R	0.684
1:247606038:T:G	S151R	0.684

dbSNP variants (sampled 300 via entrez): RS1000039203 (1:247603778 C>T), RS1000492414 (1:247606615 A>G), RS1002112744 (1:247604991 A>G), RS1002859980 (1:247605898 C>G,T), RS1004555447 (1:247604572 A>G), RS1005010174 (1:247604243 C>T), RS1006278556 (1:247605725 T>A,C), RS1007064633 (1:247605055 A>C), RS1007680285 (1:247606553 C>T), RS1007849560 (1:247605431 A>G), RS1007902073 (1:247605090 C>T), RS1008855967 (1:247604039 A>C), RS1009524482 (1:247603587 A>C,G), RS1011023228 (1:247603799 T>C), RS1011700373 (1:247604762 A>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.