OR2G6

Summary

OR2G6 (olfactory receptor family 2 subfamily G member 6, HGNC:27019) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2G6 (Q5TZ20). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391211 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001013355

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27019
Approved symbol	OR2G6
Name	olfactory receptor family 2 subfamily G member 6
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188558
Ensembl biotype	protein_coding
Entrez	391211

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641501, ENST00000641804

RefSeq mRNA: 1 — MANE Select: NM_001013355 NM_001013355

CCDS: CCDS31119

Canonical transcript exons

ENST00000641804 — 2 exons

Exon	Start	End
ENSE00003812791	248521611	248527337
ENSE00003813215	248508073	248508429

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 47.98.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	47.98	gold quality
tonsil	UBERON:0002372	41.37	gold quality
skeletal muscle tissue	UBERON:0001134	40.79	gold quality
sural nerve	UBERON:0015488	40.10	gold quality
bone marrow cell	CL:0002092	39.94	gold quality
cortical plate	UBERON:0005343	39.85	gold quality
adult mammalian kidney	UBERON:0000082	38.58	gold quality
calcaneal tendon	UBERON:0003701	38.14	gold quality
kidney	UBERON:0002113	37.90	gold quality
muscle tissue	UBERON:0002385	37.66	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
granulocyte	CL:0000094	37.19	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
leukocyte	CL:0000738	35.78	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.31	gold quality
monocyte	CL:0000576	34.73	gold quality
bone marrow	UBERON:0002371	34.70	gold quality
vermiform appendix	UBERON:0001154	34.67	gold quality
apex of heart	UBERON:0002098	34.54	gold quality
placenta	UBERON:0001987	33.77	gold quality
blood	UBERON:0000178	32.72	gold quality
liver	UBERON:0002107	32.56	gold quality
prefrontal cortex	UBERON:0000451	31.98	gold quality
prostate gland	UBERON:0002367	30.59	silver quality
metanephros cortex	UBERON:0010533	29.69	silver quality
superior frontal gyrus	UBERON:0002661	29.53	gold quality
adrenal tissue	UBERON:0018303	29.09	gold quality
frontal cortex	UBERON:0001870	28.99	gold quality
corpus callosum	UBERON:0002336	28.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.92

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2G6 — Q5TZ20 (reviewed: Q5TZ20)

All UniProt accessions (2): A0A126GW53, Q5TZ20

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001013373* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5TZ20-F1	88.63	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, HBZ_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, MEF2C_TARGET_GENES, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

116 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2G6	NWD1	Q149M9	480
OR2G6	ZNF676	Q8N7Q3	474
OR2G6	PLEKHA6	Q9Y2H5	448
OR2G6	DMXL2	Q8TDJ6	397
OR2G6	ZBTB20	Q9HC78	290
OR2G6	CSMD1	Q96PZ7	269
OR2G6	CNTLN	Q9NXG0	264
OR2G6	BCLAF1	Q9NYF8	257
OR2G6	MAIP1	Q8WWC4	248
OR2G6	DCLK1	O15075	224
OR2G6	EIF2S2	P20042	211
OR2G6	RMP64	Q6NW34	204
OR2G6	ANKRD30A	Q9BXX3	204
OR2G6	RNF43	Q68DV7	203
OR2G6	STOX2	Q9P2F5	193

IntAct

5 interactions, top by confidence:

A	B	Type	Score
CDK3	OR2G6	psi-mi:“MI:0915”(physical association)	0.560
OR2G6	UBB	psi-mi:“MI:0914”(association)	0.350
CDK3	OR2G6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): CDK3 (Two-hybrid), OR2G6 (Negative Genetic), SLC12A4 (Affinity Capture-MS), PLAA (Affinity Capture-MS), SLC12A6 (Affinity Capture-MS), KIAA1549 (Affinity Capture-MS), LRP10 (Affinity Capture-MS), DPY19L4 (Affinity Capture-MS), UBL7 (Affinity Capture-MS), ERMP1 (Affinity Capture-MS), RHBDD1 (Affinity Capture-MS), SLC44A5 (Affinity Capture-MS), UBB (Affinity Capture-MS), FAM63A (Affinity Capture-MS), SLC47A1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

347 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248521788:G:GG	donor_gain	0.6900
1:248521678:G:T	donor_gain	0.6600
1:248521677:G:GT	donor_gain	0.6500
1:248521925:C:G	donor_gain	0.6400
1:248521702:A:G	donor_gain	0.6200
1:248522315:A:G	acceptor_gain	0.6200
1:248522184:G:GC	acceptor_gain	0.6100
1:248522390:C:A	donor_gain	0.6100
1:248521718:G:GT	donor_gain	0.6000
1:248522181:TGTG:T	acceptor_gain	0.6000
1:248521850:T:A	donor_gain	0.5900
1:248521678:G:GT	donor_gain	0.5800
1:248521713:C:G	donor_gain	0.5800
1:248521934:C:G	donor_gain	0.5800
1:248521901:GAA:G	donor_gain	0.5700
1:248521975:C:G	donor_gain	0.5700
1:248522280:T:TG	donor_gain	0.5700
1:248522355:GCCTT:G	donor_gain	0.5700
1:248522458:G:T	donor_gain	0.5700
1:248522279:G:GA	donor_gain	0.5600
1:248522314:AAGCT:A	acceptor_gain	0.5600
1:248522459:A:T	donor_gain	0.5600
1:248522182:G:GG	donor_gain	0.5400
1:248522278:T:TA	donor_gain	0.5400
1:248522327:GA:G	donor_gain	0.5400
1:248522338:C:G	donor_gain	0.5400
1:248522384:T:TA	donor_gain	0.5400
1:248522462:G:GG	donor_gain	0.5400
1:248522522:G:GC	acceptor_gain	0.5400
1:248521787:A:AG	donor_gain	0.5300

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001094991 (1:248526363 G>T), RS1001357581 (1:248526457 C>A,T), RS1001484005 (1:248525860 T>A), RS1001745771 (1:248526027 A>G), RS1001763149 (1:248520871 A>T), RS1002971687 (1:248519921 A>G), RS1003156152 (1:248526904 T>A), RS1003251222 (1:248510436 T>G), RS1003904899 (1:248523393 T>G), RS1004309442 (1:248521932 G>A), RS1004556720 (1:248526592 C>G), RS1005017469 (1:248523467 ATTG>A), RS1005152639 (1:248525643 A>T), RS1005170804 (1:248527823 A>C), RS1005488807 (1:248525846 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	2
Acetaminophen	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.