OR2J3

Summary

OR2J3 (olfactory receptor family 2 subfamily J member 3, HGNC:8261) is a protein-coding gene on chromosome 6p22.1, encoding Olfactory receptor 2J3 (O76001). Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as ‘green grassy’ or the smell of ‘cut grass’.

This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6.

Source: NCBI Gene 442186 — RefSeq curated summary.

At a glance

• GWAS associations: 28
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001005216

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8261
Approved symbol	OR2J3
Name	olfactory receptor family 2 subfamily J member 3
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	OR6-6
Ensembl gene	ENSG00000204701
Ensembl biotype	protein_coding
OMIM	615016
Entrez	442186

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000377169, ENST00000641151, ENST00000641960

RefSeq mRNA: 1 — MANE Select: NM_001005216 NM_001005216

CCDS: CCDS43433

Canonical transcript exons

ENST00000383651 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 77.77.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.77	gold quality
sural nerve	UBERON:0015488	46.87	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
granulocyte	CL:0000094	36.43	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.92	gold quality
muscle tissue	UBERON:0002385	33.81	gold quality
monocyte	CL:0000576	33.73	gold quality
leukocyte	CL:0000738	33.73	gold quality
right uterine tube	UBERON:0001302	33.54	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
liver	UBERON:0002107	31.49	gold quality
urinary bladder	UBERON:0001255	30.81	gold quality
testis	UBERON:0000473	30.50	gold quality
adrenal tissue	UBERON:0018303	30.47	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
corpus callosum	UBERON:0002336	29.74	gold quality
left testis	UBERON:0004533	29.59	silver quality
prefrontal cortex	UBERON:0000451	29.52	gold quality
fallopian tube	UBERON:0003889	29.49	gold quality
rectum	UBERON:0001052	29.33	gold quality
right lobe of liver	UBERON:0001114	28.82	gold quality
calcaneal tendon	UBERON:0003701	28.49	gold quality
gall bladder	UBERON:0002110	28.43	gold quality
left uterine tube	UBERON:0001303	28.25	gold quality
blood	UBERON:0000178	28.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Two amino acid substitutions, T113A and R226Q, impaired the ability of OR2J3 to respond to cis-3-hexen-1-ol, and together these two substitutions effectively abolished the response to the compound. (PMID:22714804)
• OR2J3 activation induces apoptosis and inhibits cell proliferation and migration in long-term stimulus experiments with helional. (PMID:27939274)

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2J3 — O76001 (reviewed: O76001)

Alternative names: Hs6M1-3, Olfactory receptor OR6-16

All UniProt accessions (2): O76001, A0A126GWT2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as ‘green grassy’ or the smell of ‘cut grass’.

Subcellular location. Cell membrane.

Polymorphism. Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005216* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O76001-F1	88.62	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 100–192

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GSE13485_CTRL_VS_DAY3_YF17D_VACCINE_PBMC_UP, WEST_ADRENOCORTICAL_TUMOR_DN, WP_GPCRS_CLASS_A_RHODOPSINLIKE, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

280 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2J3	TAS2R50	P59544	575
OR2J3	TAS2R5	Q9NYW4	521
OR2J3	TAAR5	O14804	456
OR2J3	TAS2R13	Q9NYV9	447
OR2J3	RTP2	Q5QGT7	372
OR2J3	SYNE1	Q8NF91	353
OR2J3	TAS2R10	Q9NYW0	348
OR2J3	RTP1	P59025	323
OR2J3	ZNF311	Q5JNZ3	317
OR2J3	TAS2R14	Q9NYV8	305
OR2J3	TAS2R1	Q9NYW7	303
OR2J3	C17orf50	Q8WW18	300
OR2J3	TBC1D3K	A0A087X1G2	286
OR2J3	KRTAP9-7	A8MTY7	279
OR2J3	TAS2R4	Q9NYW5	276

IntAct

0 interactions, top by confidence:

BioGRID (1): OR2J3 (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

178 predictions. Top by Δscore:

Variant	Effect	Δscore
6:29112553:T:TA	acceptor_gain	0.9400
6:29112552:AT:A	acceptor_gain	0.8700
6:29112656:ATTCC:A	acceptor_gain	0.8700
6:29112553:T:G	acceptor_gain	0.8500
6:29112656:A:AG	acceptor_gain	0.8300
6:29112660:C:CA	acceptor_gain	0.8100
6:29112554:G:A	acceptor_gain	0.8000
6:29112552:ATG:A	acceptor_gain	0.7100
6:29112552:ATGGT:A	acceptor_gain	0.7000
6:29112345:GG:G	donor_gain	0.6900
6:29112346:GG:G	donor_gain	0.6900
6:29112666:T:G	acceptor_gain	0.6900
6:29112694:A:T	donor_gain	0.6900
6:29112343:TTGGG:T	donor_loss	0.6800
6:29112347:G:GA	donor_loss	0.6800
6:29112347:G:GG	donor_gain	0.6800
6:29112348:TAAGT:T	donor_loss	0.6800
6:29112661:G:A	acceptor_gain	0.6800
6:29112672:T:G	acceptor_gain	0.6800
6:29112349:A:AG	donor_loss	0.6700
6:29112552:A:AG	acceptor_gain	0.6700
6:29112657:T:G	acceptor_gain	0.6700
6:29112393:G:A	acceptor_gain	0.6200
6:29112693:G:GT	donor_gain	0.6200
6:29112527:C:G	acceptor_gain	0.6000
6:29112534:T:G	acceptor_gain	0.6000
6:29112436:TGAA:T	acceptor_gain	0.5900
6:29112437:GAAG:G	acceptor_gain	0.5900
6:29112545:A:AG	acceptor_gain	0.5900
6:29112525:T:G	acceptor_gain	0.5800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000379909 (6:29114266 A>T), RS1000383614 (6:29109935 A>G), RS1000490284 (6:29106644 A>G), RS1000811264 (6:29111622 A>G,T), RS1001592380 (6:29113745 T>A), RS1002313487 (6:29108267 G>A), RS1002394973 (6:29112917 C>T), RS1002681530 (6:29114359 C>A,T), RS1002773113 (6:29114594 G>A,C), RS1002935104 (6:29108046 T>C), RS1003217148 (6:29109512 G>A), RS1003293394 (6:29107784 G>A,T), RS1004180857 (6:29114618 T>C), RS1004221814 (6:29114989 T>C), RS1004790428 (6:29114045 A>G)

Disease associations

OMIM: gene MIM:615016 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

28 associations (top):

Study	Trait	p-value
GCST000817_84	Height	2.000000e-17
GCST002194_1	Social communication problems	3.000000e-07
GCST003518_59	Daytime sleep phenotypes	3.000000e-06
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_212	Autism spectrum disorder or schizophrenia	5.000000e-14
GCST004521_43	Autism spectrum disorder or schizophrenia	2.000000e-27
GCST004521_56	Autism spectrum disorder or schizophrenia	1.000000e-22
GCST004521_58	Autism spectrum disorder or schizophrenia	1.000000e-17
GCST004521_7	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST004521_84	Autism spectrum disorder or schizophrenia	1.000000e-12
GCST004521_91	Autism spectrum disorder or schizophrenia	1.000000e-11
GCST004749_80	Lung cancer in ever smokers	1.000000e-07
GCST004750_45	Squamous cell lung carcinoma	3.000000e-11
GCST004866_25	Alopecia areata	9.000000e-07
GCST005541_6	Sarcoidosis (Lofgren’s syndrome vs non-Lofgren’s syndrome)	7.000000e-19
GCST006575_11	Takayasu arteritis	1.000000e-06
GCST008916_89	Asthma	2.000000e-10
GCST008921_4	Asthma and major depressive disorder	2.000000e-11
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16
GCST90020028_870	Hip circumference adjusted for BMI	4.000000e-14

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0005427	social communication impairment
EFO:0007828	daytime rest measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Thiram	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.