OR2L13

Summary

OR2L13 (olfactory receptor family 2 subfamily L member 13, HGNC:19578) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2L13 (Q8N349). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 284521 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 209 total
• MANE Select transcript: NM_001395936

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19578
Approved symbol	OR2L13
Name	olfactory receptor family 2 subfamily L member 13
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196071
Ensembl biotype	protein_coding
Entrez	284521

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000358120, ENST00000641714, ENST00000641893

RefSeq mRNA: 3 — MANE Select: NM_001395936 NM_001304535, NM_001395936, NM_175911

CCDS: CCDS1637

Canonical transcript exons

ENST00000358120 — 3 exons

Exon	Start	End
ENSE00001441816	248098651	248098775
ENSE00003812202	248095184	248095254
ENSE00003978245	248099358	248101163

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 76.66.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0371 / max 82.5033, expressed in 271 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9651	1.0371	271

Top tissues by expression

211 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	76.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.62	gold quality
spinal cord	UBERON:0002240	72.50	gold quality
frontal cortex	UBERON:0001870	68.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.85	gold quality
hypothalamus	UBERON:0001898	67.69	gold quality
endothelial cell	CL:0000115	67.63	silver quality
neocortex	UBERON:0001950	67.49	gold quality
right frontal lobe	UBERON:0002810	66.06	gold quality
anterior cingulate cortex	UBERON:0009835	65.80	gold quality
cortical plate	UBERON:0005343	65.74	gold quality
cerebral cortex	UBERON:0000956	64.49	gold quality
substantia nigra	UBERON:0002038	63.97	gold quality
primary visual cortex	UBERON:0002436	63.90	gold quality
putamen	UBERON:0001874	63.11	gold quality
caudate nucleus	UBERON:0001873	62.22	gold quality
nucleus accumbens	UBERON:0001882	62.13	gold quality
forebrain	UBERON:0001890	61.59	gold quality
amygdala	UBERON:0001876	61.46	gold quality
midbrain	UBERON:0001891	61.21	gold quality
ventricular zone	UBERON:0003053	61.10	gold quality
brain	UBERON:0000955	60.29	gold quality
Ammon’s horn	UBERON:0001954	59.85	gold quality
occipital lobe	UBERON:0002021	59.36	gold quality
lower lobe of lung	UBERON:0008949	58.11	silver quality
superior frontal gyrus	UBERON:0002661	55.58	gold quality
Brodmann (1909) area 46	UBERON:0006483	55.45	silver quality
temporal lobe	UBERON:0001871	54.84	gold quality
cerebellar cortex	UBERON:0002129	54.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting OR2L13, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-12129	99.72	67.45	1311
HSA-MIR-2053	99.57	69.15	1635
HSA-MIR-7159-3P	99.51	70.17	1920
HSA-MIR-4643	99.49	67.63	1791
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-183-3P	99.41	69.41	1598
HSA-MIR-889-3P	99.40	69.76	2103
HSA-MIR-4797-5P	99.39	68.01	1354
HSA-MIR-16-2-3P	99.29	70.60	1954

Literature-anchored findings (GeneRIF, showing 2)

• RNA-Seq evidence of testis-specific monoallelic expression of OR2L13, located 419 kb downstream of the GCSAML somatic (secondary), imprinted differentially methylated region (iDMR). OR2L13 has a predicted CGI-bearing allelically methylated region overlapping the promoter region in blood, spleen, lung, liver, esophagus, and brain, but hypomethylated in gamete, blastocyst, placenta, thymus, and spinal cord methylomes. (PMID:29545821)
• Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. (PMID:35324479)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2l13	ENSMUSG00000056822
mus_musculus	Or2l13b	ENSMUSG00000061361
rattus_norvegicus	Or2l13c	ENSRNOG00000074249
rattus_norvegicus	Or2l13	ENSRNOG00000074329

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2L13 — Q8N349 (reviewed: Q8N349)

Alternative names: Olfactory receptor 2L14

All UniProt accessions (2): A0A126GW96, Q8N349

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (3): NP_001291464, NP_001382865, NP_787107 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N349-F1	89.83	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (2): 5, 20

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 58 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, RNGTGGGC_UNKNOWN, GCANCTGNY_MYOD_Q6, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, AAAYRNCTG_UNKNOWN, CAGCTG_AP4_Q5, PAX2_01, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, RFX1_02, chr1q44, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, PITX2_Q2, GOMF_OLFACTORY_RECEPTOR_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

602 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2L13	C11orf21	Q9P2W6	583
OR2L13	TAS2R50	P59544	573
OR2L13	TAS2R13	Q9NYV9	541
OR2L13	C14orf119	Q9NWQ9	507
OR2L13	TAS2R5	Q9NYW4	506
OR2L13	B3KSW5	B3KSW5	476
OR2L13	RNF167	Q9H6Y7	475
OR2L13	PRKG1	P14619	449
OR2L13	FAM181A	Q8N9Y4	433
OR2L13	TAS2R10	Q9NYW0	432
OR2L13	PYROXD1	Q8WU10	420
OR2L13	CACNA2D3	Q8IZS8	415
OR2L13	OR2C1	O95371	412
OR2L13	OR1J2	Q8NGS2	407
OR2L13	TSPAN32	Q96QS1	402

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2L13	SERPINA1	psi-mi:“MI:0914”(association)	0.350

BioGRID (6): SERPINA1 (Affinity Capture-MS), ALB (Affinity Capture-MS), CDSN (Affinity Capture-MS), IGHG3 (Affinity Capture-MS), GPX7 (Affinity Capture-MS), OR2L13 (Two-hybrid)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

209 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	198
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

326 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248099353:A:AG	acceptor_gain	0.9900
1:248099356:A:AG	acceptor_gain	0.9900
1:248099357:G:GA	acceptor_gain	0.9900
1:248099354:ACAGT:A	acceptor_loss	0.9800
1:248099355:CA:C	acceptor_loss	0.9800
1:248099356:A:C	acceptor_loss	0.9800
1:248099357:GT:G	acceptor_gain	0.9700
1:248099357:GTTAC:G	acceptor_gain	0.9700
1:248099354:A:G	acceptor_gain	0.9600
1:248099357:GTT:G	acceptor_gain	0.9600
1:248099357:GTTA:G	acceptor_gain	0.9600
1:248099343:T:G	acceptor_gain	0.9500
1:248095195:AAT:A	acceptor_gain	0.9200
1:248099482:T:TA	acceptor_gain	0.9200
1:248099342:A:AG	acceptor_gain	0.9000
1:248098782:G:GT	donor_gain	0.8900
1:248099488:C:A	acceptor_gain	0.8900
1:248098649:A:AG	acceptor_gain	0.8800
1:248098650:G:GG	acceptor_gain	0.8800
1:248099355:C:G	acceptor_gain	0.8600
1:248099473:T:G	acceptor_gain	0.8600
1:248099492:G:A	acceptor_gain	0.8300
1:248095195:A:AG	acceptor_gain	0.8200
1:248099352:CAACA:C	acceptor_gain	0.8000
1:248099562:AGC:A	acceptor_gain	0.7900
1:248099353:AACAG:A	acceptor_gain	0.7800
1:248099354:ACAG:A	acceptor_gain	0.7700
1:248099355:CAG:C	acceptor_gain	0.7500
1:248095197:T:TA	acceptor_gain	0.7300
1:248099483:G:A	acceptor_gain	0.7200

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000070318 (1:248066040 G>A), RS1000074814 (1:247937284 G>A,C,T), RS1000076295 (1:247956822 T>A), RS1000084688 (1:247949745 G>A), RS1000114889 (1:248032603 A>G), RS1000117117 (1:248032932 G>T), RS1000128152 (1:248096322 G>A,T), RS1000143677 (1:248018814 C>T), RS1000143768 (1:247989317 T>C), RS1000147238 (1:248016575 G>A,T), RS1000192011 (1:247976585 A>T), RS1000208081 (1:248060682 A>G), RS1000260703 (1:248089570 G>A), RS1000264473 (1:248054437 C>G), RS1000273037 (1:248031580 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Vehicle Emissions	affects methylation, increases abundance, increases methylation	2
bisphenol F	decreases methylation, affects cotreatment	1
bisphenol A	affects methylation, affects cotreatment	1
2-palmitoylglycerol	increases expression	1
bisphenol S	decreases methylation	1
Fulvestrant	decreases methylation, affects cotreatment, affects methylation	1
Air Pollutants	affects methylation, increases abundance	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Nitrogen Dioxide	affects methylation, increases abundance	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.