OR2L3

Summary

OR2L3 (olfactory receptor family 2 subfamily L member 3, HGNC:15009) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2L3 (Q8NG85). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391192 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001004687

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15009
Approved symbol	OR2L3
Name	olfactory receptor family 2 subfamily L member 3
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000198128
Ensembl biotype	protein_coding
Entrez	391192

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000359959, ENST00000641161, ENST00000641649

RefSeq mRNA: 1 — MANE Select: NM_001004687 NM_001004687

CCDS: CCDS31104

Canonical transcript exons

ENST00000359959 — 2 exons

Exon	Start	End
ENSE00002392655	248060661	248063407
ENSE00003813392	248046836	248046880

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 54.82.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	54.82	silver quality
sural nerve	UBERON:0015488	46.53	gold quality
ventricular zone	UBERON:0003053	44.20	silver quality
primary visual cortex	UBERON:0002436	44.12	silver quality
prefrontal cortex	UBERON:0000451	43.93	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	43.56	gold quality
ganglionic eminence	UBERON:0004023	42.58	gold quality
bone marrow cell	CL:0002092	40.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	40.38	silver quality
calcaneal tendon	UBERON:0003701	40.29	gold quality
frontal cortex	UBERON:0001870	40.21	silver quality
monocyte	CL:0000576	39.97	gold quality
cerebellar cortex	UBERON:0002129	39.50	silver quality
smooth muscle tissue	UBERON:0001135	39.33	silver quality
cerebellum	UBERON:0002037	39.33	silver quality
leukocyte	CL:0000738	38.86	gold quality
substantia nigra	UBERON:0002038	38.70	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	38.60	silver quality
hypothalamus	UBERON:0001898	38.56	silver quality
right hemisphere of cerebellum	UBERON:0014890	38.41	silver quality
apex of heart	UBERON:0002098	38.21	silver quality
corpus callosum	UBERON:0002336	37.77	gold quality
blood	UBERON:0000178	37.64	gold quality
lower esophagus mucosa	UBERON:0035834	37.37	gold quality
Ammon’s horn	UBERON:0001954	37.33	silver quality
bone marrow	UBERON:0002371	37.31	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
muscle tissue	UBERON:0002385	36.96	gold quality
endometrium	UBERON:0001295	36.52	gold quality
amygdala	UBERON:0001876	36.25	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.12

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2l5	ENSMUSG00000045341
rattus_norvegicus	Or2l5	ENSRNOG00000081703

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2L3 — Q8NG85 (reviewed: Q8NG85)

All UniProt accessions (1): Q8NG85

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004687* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 4, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG85-F1	91.36	0.77

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (2): 5, 88

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SRPK2_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

104 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2L3	AK9	Q5TCS8	419
OR2L3	PLBD1	Q6P4A8	368
OR2L3	MMAB	Q96EY8	358
OR2L3	SLC22A10	Q63ZE4	353
OR2L3	MAGEB16	A2A368	353
OR2L3	SLC22A24	Q8N4F4	353
OR2L3	MMS22L	Q6ZRQ5	351
OR2L3	DEGS2	Q6QHC5	329
OR2L3	FXYD3	Q14802	317
OR2L3	IQGAP3	Q86VI3	311
OR2L3	TMEM244	Q5VVB8	311
OR2L3	CDON	Q4KMG0	287
OR2L3	DYNC2H1	Q8NCM8	279
OR2L3	NUP210	Q8TEM1	271
OR2L3	RYR3	Q15413	222

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

630 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248046983:A:G	donor_gain	0.9200
1:248051242:G:GG	donor_gain	0.8900
1:248047783:GT:G	donor_gain	0.8400
1:248048499:G:GT	donor_gain	0.8400
1:248053058:GTAT:G	donor_gain	0.8300
1:248053059:TATT:T	donor_gain	0.8300
1:248053060:ATTA:A	donor_gain	0.8300
1:248061564:G:GT	donor_gain	0.8100
1:248047636:G:A	acceptor_gain	0.8000
1:248053061:T:TG	donor_gain	0.8000
1:248047635:C:CA	acceptor_gain	0.7900
1:248061588:G:GG	donor_gain	0.7900
1:248051186:AG:A	acceptor_gain	0.7800
1:248051187:GG:G	acceptor_gain	0.7800
1:248055340:C:A	donor_gain	0.7600
1:248061586:GA:G	donor_gain	0.7400
1:248048465:G:GT	donor_gain	0.7300
1:248061324:T:G	acceptor_gain	0.7300
1:248061451:C:G	acceptor_gain	0.7200
1:248061449:C:G	acceptor_gain	0.7000
1:248052963:TTAAG:T	acceptor_gain	0.6900
1:248052964:TAAGT:T	acceptor_gain	0.6900
1:248061323:AT:A	acceptor_gain	0.6900
1:248061332:T:G	acceptor_gain	0.6900
1:248061323:A:AG	acceptor_gain	0.6800
1:248061005:TGCAG:T	donor_gain	0.6700
1:248061314:T:TA	acceptor_gain	0.6700
1:248061450:A:AG	acceptor_gain	0.6700
1:248061570:A:AG	donor_gain	0.6700
1:248052965:AAG:A	acceptor_gain	0.6600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000208081 (1:248060682 A>G), RS1000264473 (1:248054437 C>G), RS1000371688 (1:248048191 C>T), RS1000541941 (1:248061924 T>A), RS1000651166 (1:248055607 AT>A), RS1000707841 (1:248049700 C>T), RS1000722233 (1:248054128 T>C), RS1001122768 (1:248046661 T>C), RS1001175080 (1:248046390 A>G), RS1001597951 (1:248048622 C>T), RS1001866091 (1:248060170 C>A), RS1001887397 (1:248056287 AT>A,ATT), RS1001908278 (1:248055186 A>T), RS1001964548 (1:248049810 A>T), RS1002172149 (1:248044933 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
mancozeb	decreases expression	1
CGP 52608	affects binding, increases reaction	1
(+)-JQ1 compound	increases expression	1
Arsenic	affects methylation	1
Niclosamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.