OR2L5

Summary

OR2L5 (olfactory receptor family 2 subfamily L member 5, HGNC:15011) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2L5 (Q8NG80). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81466 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001258284

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15011
Approved symbol	OR2L5
Name	olfactory receptor family 2 subfamily L member 5
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197454
Ensembl biotype	protein_coding
Entrez	81466

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000355281

RefSeq mRNA: 1 — MANE Select: NM_001258284 NM_001258284

CCDS: CCDS58068

Canonical transcript exons

ENST00000355281 — 2 exons

Exon	Start	End
ENSE00003811573	248013660	248013738
ENSE00003814192	248021927	248024276

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 48.60.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.60	gold quality
cortical plate	UBERON:0005343	43.61	gold quality
bone marrow cell	CL:0002092	42.89	gold quality
primary visual cortex	UBERON:0002436	40.18	silver quality
granulocyte	CL:0000094	39.55	gold quality
bone marrow	UBERON:0002371	37.40	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
prefrontal cortex	UBERON:0000451	35.82	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
leukocyte	CL:0000738	35.09	gold quality
monocyte	CL:0000576	34.58	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	32.57	gold quality
tonsil	UBERON:0002372	32.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	30.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	30.30	gold quality
spleen	UBERON:0002106	30.26	gold quality
liver	UBERON:0002107	30.14	gold quality
lymph node	UBERON:0000029	29.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	29.94	gold quality
blood	UBERON:0000178	29.90	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	29.43	gold quality
right frontal lobe	UBERON:0002810	29.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	29.00	gold quality
nucleus accumbens	UBERON:0001882	28.91	gold quality
cerebellum	UBERON:0002037	28.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2l5	ENSMUSG00000045341
rattus_norvegicus	Or2l5	ENSRNOG00000081703

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2L5 — Q8NG80 (reviewed: Q8NG80)

Alternative names: Olfactory receptor 2L11, Olfactory receptor OR1-53

All UniProt accessions (2): Q8NG80, A0A126GWR8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001245213* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG80-F1	90.59	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_DN, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

40 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2L5	CACNA2D3	Q8IZS8	198
OR2L5	RNF167	Q9H6Y7	187
OR2L5	HAUS3	Q68CZ6	73
OR2L5	ARRB2	P32121	56
OR2L5	ARRB1	P49407	56
OR2L5	PRKACA	P17612	42
OR2L5	GRK2	P25098	42
OR2L5	GRK3	P35626	42
OR2L5	PRKACG	P22612	42
OR2L5	PRKACB	P22694	42
OR2L5	GNG13	Q9P2W3	0
OR2L5	TP53	P04637	0
OR2L5	GNAL	P38405	0
OR2L5	C5AR1	P21730	0
OR2L5	GNG7	O60262	0
OR2L5	GNB1	P04697	0
OR2L5	OR2AK2	Q8NG84	0

IntAct

0 interactions, top by confidence:

BioGRID (1): OR2L5 (Negative Genetic)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

619 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248015368:G:GT	donor_gain	0.9800
1:248022878:AAAAT:A	donor_gain	0.9600
1:248015457:AC:A	donor_gain	0.8300
1:248015405:A:G	donor_gain	0.8200
1:248022360:GAAT:G	donor_gain	0.8200
1:248022830:G:GT	donor_gain	0.8000
1:248013853:ATT:A	donor_gain	0.7900
1:248015371:G:GT	donor_gain	0.7900
1:248017026:T:G	acceptor_gain	0.7900
1:248021004:G:GG	donor_gain	0.7700
1:248020275:G:GT	donor_gain	0.7600
1:248015273:GGA:G	acceptor_gain	0.7400
1:248022176:GTTCC:G	donor_gain	0.7100
1:248022177:TTCCT:T	donor_gain	0.7100
1:248022363:T:G	donor_gain	0.7100
1:248024065:ATGGG:A	acceptor_gain	0.7100
1:248022876:TGAAA:T	donor_gain	0.7000
1:248022180:C:CG	donor_gain	0.6900
1:248022202:G:GG	donor_gain	0.6900
1:248022120:T:G	donor_gain	0.6700
1:248015273:GGAGA:G	acceptor_gain	0.6600
1:248022201:T:G	donor_gain	0.6500
1:248022260:A:T	acceptor_gain	0.6500
1:248015272:A:AG	acceptor_gain	0.6400
1:248015273:G:GG	acceptor_gain	0.6400
1:248022642:G:GT	donor_gain	0.6400
1:248022725:T:G	acceptor_gain	0.6400
1:248022131:C:G	donor_gain	0.6300
1:248015268:TCTTA:T	acceptor_loss	0.6000
1:248015269:CTTAG:C	acceptor_loss	0.6000

AlphaMissense

2054 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248021978:T:C	F11L	0.872
1:248021980:C:A	F11L	0.872
1:248021980:C:G	F11L	0.872
1:248022473:T:C	F176L	0.840
1:248022475:T:A	F176L	0.840
1:248022475:T:G	F176L	0.840
1:248022476:T:C	F177L	0.826
1:248022478:C:A	F177L	0.826
1:248022478:C:G	F177L	0.826
1:248022548:A:C	S201R	0.815
1:248022550:C:A	S201R	0.815
1:248022550:C:G	S201R	0.815
1:248022815:A:C	S290R	0.800
1:248022817:C:A	S290R	0.800
1:248022817:C:G	S290R	0.800
1:248022047:T:C	F34L	0.784
1:248022049:C:A	F34L	0.784
1:248022049:C:G	F34L	0.784
1:248022197:T:C	F84L	0.771
1:248022199:T:A	F84L	0.771
1:248022199:T:G	F84L	0.771
1:248022248:T:C	F101L	0.761
1:248022250:C:A	F101L	0.761
1:248022250:C:G	F101L	0.761
1:248022309:G:C	R121P	0.751
1:248022245:A:C	S100R	0.742
1:248022247:T:A	S100R	0.742
1:248022247:T:G	S100R	0.742
1:248022298:G:A	M117I	0.741
1:248022298:G:C	M117I	0.741

dbSNP variants (sampled 300 via entrez): RS1000143677 (1:248018814 C>T), RS1000147238 (1:248016575 G>A,T), RS1000287973 (1:248016842 A>G), RS1000349523 (1:248021870 A>G,T), RS1001368871 (1:248013517 A>G), RS1001378855 (1:248013241 A>G), RS1001432288 (1:248017451 G>A,T), RS1001862211 (1:248017072 G>A), RS1001877793 (1:248017523 G>C,T), RS1001914964 (1:248012856 A>C,G), RS1001976484 (1:248022800 A>C), RS1002268003 (1:248017697 C>T), RS1002332095 (1:248011901 T>C,G), RS1002581285 (1:248019764 C>G,T), RS1002602358 (1:248014395 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	decreases expression, affects cotreatment	1
Copper	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.